Metabolism of daidzein and genistein by intestinal bacteria

Y C Chang; M G Nair

doi:10.1021/np50126a014

Metabolism of daidzein and genistein by intestinal bacteria

J Nat Prod. 1995 Dec;58(12):1892-6. doi: 10.1021/np50126a014.

Authors

Y C Chang¹, M G Nair

Affiliation

¹ Department of Horticulture and Pesticide Research Center, Michigan State University, East Lansing 48824, USA.

PMID: 8691209
DOI: 10.1021/np50126a014

Abstract

The isoflavones daidzein [1] and genistein [2] were fermented with human fecal bacteria under anaerobic conditions. Dihydrodaidzein [3], benzopyran-4,7-diol,3-(4-hydroxyphenyl) [4], and equol [5] were isolated from the fermentation broth of 1. Only one metabolite, dihydrogenistein [6], was isolated and characterized from the fermentation broth of 2. Metabolites 3-6 were identified by spectral methods.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bacteria / metabolism*
Chromatography, High Pressure Liquid
Estrogens, Non-Steroidal / chemistry
Estrogens, Non-Steroidal / metabolism*
Fermentation
Genistein
Humans
Intestinal Mucosa / metabolism
Intestines / microbiology*
Isoflavones / chemistry
Isoflavones / metabolism*

Substances

Estrogens, Non-Steroidal
Isoflavones
daidzein
Genistein