Isolation of pyropheophorbide a from the leaves of Atalantia monophylla (ROXB.) CORR. (Rutaceae) as a possible antiviral active principle against herpes simplex virus type 2

Chem Pharm Bull (Tokyo). 1996 Jul;44(7):1415-7. doi: 10.1248/cpb.44.1415.

Abstract

Antiviral activity-guided isolation studies on the leaves of Atalantia monophylla (ROXB.) CORR. (Rutaceae) led to the identification of pyropheophorbide a (1), a simple chlorin derivative, from the chloroform extract (fr. B) as a possible antiviral active principle against herpes simplex virus type 2 (HSV-2). Pyropheophorbide a methyl ester (2) was also isolated from the hexane extract (fr. A).

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology*
  • Chlorocebus aethiops
  • Chlorophyll / analogs & derivatives*
  • Chlorophyll / isolation & purification
  • Chlorophyll / pharmacology
  • Herpesvirus 2, Human / drug effects*
  • Herpesvirus 2, Human / growth & development
  • Plant Extracts / pharmacology
  • Vero Cells
  • Viral Plaque Assay

Substances

  • Antiviral Agents
  • Plant Extracts
  • Chlorophyll
  • pyropheophorbide a