New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii

J Nat Prod. 1996 Aug;59(8):754-8. doi: 10.1021/np9603784.

Abstract

During a chemotaxonomic survey of Calophyllum extracts present in the National Cancer Institute's natural product repository, four new pyranocoumarins were isolated from extracts of C. lanigerum var. austrocoriaceum and C. teysmannii var. inophylloide (King.) P. F. Stevens (Clusiaceae). The structure elucidation and anti-HIV activity of calanolide E2 (4), cordatolide E (5), pseudocordatolide C (6), and calanolide F (9), along with a simple prenylated coumarin precursor (11), are described here.

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology
  • Coumarins / chemistry*
  • Coumarins / isolation & purification
  • Coumarins / pharmacology
  • HIV / drug effects*
  • Latex / chemistry
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Pyranocoumarins
  • Spectrometry, Mass, Fast Atom Bombardment
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Coumarins
  • Latex
  • Plant Extracts
  • Pyranocoumarins
  • calanolide E2
  • cordatolide E
  • pseudocordatolide C
  • calanolide A