Abstract
Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology*
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Carbohydrate Sequence
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HIV-1 / drug effects*
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HIV-1 / enzymology*
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Humans
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Hydrolysis
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Hydrolyzable Tannins*
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Reverse Transcriptase Inhibitors / isolation & purification
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Reverse Transcriptase Inhibitors / pharmacology*
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Tannins / isolation & purification
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Tannins / pharmacology*
Substances
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Antiviral Agents
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Hydrolyzable Tannins
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Reverse Transcriptase Inhibitors
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Tannins
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shephagenin A
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shephagenin B