Test and symptoms in keratoconjunctivitis sicca and their correlation

Acta Ophthalmol Scand. 1996 Oct;74(5):436-41. doi: 10.1111/j.1600-0420.1996.tb00595.x.

Abstract

Results of dry eye tests and ocular symptoms were compared and correlated in patients with primary Sjögren's syndrome (1 degree SS), in patients with connective tissue disease differing from 1 degree SS, and in normal controls. Patients with 1 degree SS had many and pronounced ocular complaints, however, non-diagnostic for the disease. Break-up time and Schirmer-1 test results below 10 mm/5 min both had high sensitivity but low specificity, whereas the reverse was true for Rose-Bengal score and Schirmer-1 test below 5 mm/5 min. Presence of snake-like chromatin in conjunctival imprints and the lactotest on tear fluid did not qualify as alternative tests since they had very low specificity and were less sensitive than the Schirmer-1 test and break-up time. Cornea sensitivity was not found to be an appropriate test at all. In 21% of eyes the presence of keratoconjunctivitis sicca changed from one consultation to the next in patients with 1 degree SS. Examination for keratoconjunctivitis sicca should therefore be repeated in test negative cases where symptoms indicate 1 degree SS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Diagnosis, Differential
  • Diagnostic Tests, Routine / methods*
  • Female
  • Humans
  • Keratoconjunctivitis Sicca / diagnosis*
  • Keratoconjunctivitis Sicca / epidemiology
  • Keratoconjunctivitis Sicca / metabolism
  • Lactoferrin / analysis
  • Male
  • Middle Aged
  • Prevalence
  • Sensitivity and Specificity
  • Sjogren's Syndrome / diagnosis*
  • Sjogren's Syndrome / epidemiology
  • Sjogren's Syndrome / metabolism
  • Surveys and Questionnaires
  • Tears / chemistry

Substances

  • Lactoferrin