Abstract
Moloney murine leukemia virus is a prototypical simple retrovirus that has been an extremely useful model for leukemogenesis. Important steps in leukemogenesis include proviral activation of cellular proto-oncogenes, generation of mink cell focus-inducing recombinants, and early (preleukemic) virus-induced changes in hematopoiesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cocarcinogenesis
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Gene Expression Regulation, Neoplastic
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Leukemia, Experimental / etiology*
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Mice
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Mink Cell Focus-Inducing Viruses / genetics
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Mink Cell Focus-Inducing Viruses / pathogenicity
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Moloney murine leukemia virus / genetics
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Moloney murine leukemia virus / pathogenicity*
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Preleukemia / etiology
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Proto-Oncogenes
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Recombination, Genetic
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Retroviridae Infections / etiology*
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Tumor Virus Infections / etiology*