Grapefruits and drugs: when is statistically significant clinically significant?

J Clin Invest. 1997 May 15;99(10):2297-8. doi: 10.1172/JCI119405.
No abstract available

Publication types

  • Comment
  • Editorial
  • Review

MeSH terms

  • Animals
  • Aryl Hydrocarbon Hydroxylases*
  • Beverages*
  • Citrus*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / metabolism
  • Felodipine / blood
  • Felodipine / pharmacokinetics
  • Humans
  • Metabolic Clearance Rate
  • Nifedipine / blood
  • Nifedipine / pharmacokinetics
  • Oxidoreductases, N-Demethylating / metabolism
  • Pharmacokinetics*
  • Smoking

Substances

  • Cytochrome P-450 Enzyme System
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP3A
  • Oxidoreductases, N-Demethylating
  • Nifedipine
  • Felodipine