Abstract
The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774. 16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antibodies, Monoclonal / metabolism
-
Antibodies, Monoclonal / pharmacology*
-
Antifungal Agents / pharmacology*
-
Cryptococcosis / drug therapy
-
Cryptococcosis / therapy*
-
Cryptococcus neoformans / drug effects*
-
Cryptococcus neoformans / metabolism
-
Female
-
Flucytosine / pharmacology*
-
Immunoglobulin G / immunology
-
Macrophages / drug effects
-
Macrophages / microbiology
-
Mice
-
Mice, Inbred A
-
Microbial Sensitivity Tests
-
Phagocytosis / drug effects
-
Polysaccharides / metabolism*
Substances
-
Antibodies, Monoclonal
-
Antifungal Agents
-
Immunoglobulin G
-
Polysaccharides
-
glucuronoxylomannan
-
Flucytosine