Betulinic acid: isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester

G Bringmann; W Saeb; L A Assi; G François; A S Sankara Narayanan; K Peters; E M Peters

doi:10.1055/s-2006-957666

Betulinic acid: isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester

Planta Med. 1997 Jun;63(3):255-7. doi: 10.1055/s-2006-957666.

Authors

G Bringmann¹, W Saeb, L A Assi, G François, A S Sankara Narayanan, K Peters, E M Peters

Affiliation

¹ Institut für Organische Chemie der Universität, Würzburg, Germany.

PMID: 9225608
DOI: 10.1055/s-2006-957666

Abstract

The known lupane-type triterpene betulinic acid (3) was isolated for the first time from Triphyophyllum peltatum and Ancistrocladus heyneanus. It was found to exhibit moderate to good in vitro antimalarial activity against asexual erythrocytic stages of the human malaria parasite Plasmodium falciparum. A first X-ray structure analysis succeeded after conversion into its benzyl ester 4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / toxicity
Betulinic Acid
Crystallography, X-Ray
Erythrocytes / parasitology
Humans
Models, Molecular
Molecular Structure
Pentacyclic Triterpenes
Plants, Medicinal*
Plasmodium falciparum / drug effects*
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / toxicity

Substances

Antimalarials
Pentacyclic Triterpenes
Triterpenes
Betulinic Acid