Evaluation of growth promotion and inhibition from mycobactins and nonmycobacterial siderophores (Desferrioxamine and FR160) in Mycobacterium aurum

Antimicrob Agents Chemother. 1997 Aug;41(8):1837-9. doi: 10.1128/AAC.41.8.1837.

Abstract

Heterologous mycobactins and the synthetic FR160 [N4-nonyl,N1,N8-bis(2,3-dihydroxybenzoyl) spermidine hydrobromide (C3 0H4 6N3, O6 Br)] promoted growth in Mycobacterium aurum in low concentrations. They were otherwise highly inhibitory, as opposed to homologous mycobactin, which was strictly growth promoting. Desferrioxamine B (Desferal) had no significant effect on growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Division / drug effects
  • Deferoxamine / pharmacology*
  • Evaluation Studies as Topic
  • Mycobacterium / drug effects*
  • Oxazoles / pharmacology*
  • Siderophores / pharmacology*
  • Spermidine / analogs & derivatives*
  • Spermidine / pharmacology
  • Time Factors

Substances

  • FR 160
  • Oxazoles
  • Siderophores
  • mycobactins
  • Deferoxamine
  • Spermidine