Abstract
A new structural class of the antibiotic, epoxyquinomicins A, B, C and D were isolated from the culture broth of the strain MK299-95F4, which was related to Amycolatopsis sulphurea. Antimicrobial activity of epoxyquinomicins A and B were weak against Gram-positive bacteria, and epoxyquinomicins C and D showed almost no antimicrobial activity and no cytotoxicity. All these antibiotics showed improvement of collagen induced arthritis in vivo.
MeSH terms
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Actinobacteria / chemistry*
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Actinobacteria / classification
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Actinobacteria / metabolism
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Animals
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Bacteria / drug effects
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Benzamides / isolation & purification
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Benzamides / pharmacology
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Mice
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Microbial Sensitivity Tests
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Quinones / isolation & purification
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Quinones / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Benzamides
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Quinones
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epoxyquinomicin A
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epoxyquinomicin B
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epoxyquinomicin C
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epoxyquinomicin D