Abstract
The antifungal and cytostatic compound strobilurin M (1) is a new variant of the strobilurins produced by Mycena sp. 96097, a tropical basidiomycete. The same fungus was found to produce tetrachloropyrocatechol (3a) and tetrachloropyrocatechol methyl ether (3b), new natural products, which exhibit antifungal, antibacterial and cytotoxic activities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Agaricales / chemistry
-
Agaricales / metabolism*
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / metabolism
-
Anti-Bacterial Agents / pharmacology*
-
Antifungal Agents / pharmacology
-
Catechols / chemistry*
-
Catechols / metabolism
-
Catechols / pharmacology*
-
Drug Evaluation, Preclinical
-
Esters / chemistry*
-
Esters / metabolism
-
Esters / pharmacology*
-
Fatty Acids, Unsaturated / chemistry*
-
Fatty Acids, Unsaturated / isolation & purification
-
Fatty Acids, Unsaturated / metabolism*
-
Fatty Acids, Unsaturated / pharmacology*
-
Fermentation
-
Glucose / chemistry*
-
Glucose / isolation & purification
-
Glucose / metabolism*
-
HeLa Cells / drug effects
-
Humans
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Methacrylates
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Oxygen / metabolism
-
Penicillium / drug effects
-
Penicillium / metabolism
-
Strobilurins
Substances
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Catechols
-
Esters
-
Fatty Acids, Unsaturated
-
Methacrylates
-
Strobilurins
-
fattiviracin A1
-
strobilurin M
-
tetrachloropyrocatechol
-
tetrachloropyrocatechol methyl ester
-
Glucose
-
Oxygen