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33814510,32020584,30364229,29427785,28988120,28437613,26699812,26640276,26221077,26091108,25860621,25811541,25481498,25455453,25329374,24136188,24085192,23452331,23024081,23017455,23013848,22972107,22967190,22966891,22960763,22958096,22957065,22897467,22887479,22879383,22878271,22870474,22826074,22821419,22815870,22813350,22772888,22766086,22763150,22751597,22741783,22703852,22690387,22679188,22666471,22654630,22654502,22649467,22645614,22640655,22639744,22629432,22613676,22612757,22590329,22580100,22578964,22570845,22570799,22567482,22567036,22563027,22539983,22538197,22516985,22508181,22505700,22505564,22500176,22479483,22465339,22461534,22450598,22438939,22438671,22420649,22413068,22406086,22401133,22400913,22389919,22389802,22389798,22383918,22379455,22379184,22376948,22371643,22370803,22353705,22347541,22341583,22341526,22319420,22316181,22312391,22307734,22301842,22298075,22297608,22297155,22294628,22289162,22281228,22279513,22279510,22278631,22271223,22270725,22269186,22252389,22245957,22245049,22243699,22242205,22242167,22242124,22234148,22233420,22229089,22224084,22216379,22199828,22199725,22195005,22194709,22194678,22192852,22175133,22166255,22162990,22162693,22146575,22146243,22135702,22124984,22121511,22119277,22117835,22113609,22113134,22098827,22096546,22096357,22094132,22093814,22093579,22086504,22084614,22084578,22073935,22072733,22059801,22057872,22052362,22052286,22050731,22046967,22035090,22034564,22028826,22028533,22027587,22024532,22018032,22013422,22011252,22008667,22004230,21998630,21997404,21995753,21994565,21994233,21985823,21985166,21983397,21978430,21975788,21972242,21969783,21962758,21961704,21954446,21936963,21935335,21935266,21933396,21929807,21917824,21914628,21904814,21890617,21890615,21888174,21884589,21881988,21876969,21875023,21871883,21862107,21861807,21857366,21851603,21845515,21803753,21803751,21794814,21794790,21794704,21794643,21794633,21794632,21794580,21791097,21789041,21786602,21785399,21776448,21775763,21775527,21767407,21766009,21760803,21755815,21754179,21740588,21738721,21729173,21722342,21722341,21722332,21722330,21708910,21707997,21703468,21696058,21686163,21682863,21677887,21660199,21650085,21642590,21630616,21629538,21625605,21625416,21624183,21624181,21618201,21615755,21611196,21605439,21603155,21600180,21600054,21595593,21590779,21589949,21584420,21584235,21578861,21571420,21565914,21555813,21547047,21546349,21542877,21540358,21523217,21510883,21504597,21496415,21486617,21453459,21448467,21437065,21436974,21430905,21430780,21427581,21424533,21423713,21415959,21415050,21410659,21410426,21401925,21383913,21378570,21378402,21371999,21371350,21367665,21365950,21365940,21365318,21362710,21360007,21355448,21349677,21345295,21330639,21324169,21321002,21314928,21307642,21303509,21303481,21286771,21285116,21283732,21277482,21272347,21269496,21269311,21265846,21255431,21243491,21242235,21234269,21229373,21221193,21221183,21219130,21211063,21205510,21193642,21189905,21187298,21184686,21179199,21174621,21173013,21161534,21161285,21158951,21157651,21152919,21151622,21132550,21127878,21122272,21120498,21116333,21114845,21109332,21085655,21079551,21078723,21072312,21072180,21068083,21060688,21046421,21045198,21044434,21042682,20981233,20980704,20972558,20970226,20957046,20948746,20929536,20885012,20884856,20877590,20874647,20862377,20861148,20856685,20843910,20840474,20838658,20821752,20800319,20798949,20738854,20737179,20735862,20729482,20717530,20704609,20696283,20689824,20683281,20653937,20650041,20648003,20643586,20633267,20617753,20617358,20617147,20613984,20601656,20596538,20596502,20596051,20574648,20573267,20569501,20563618,20563249,20555303,20546618,20542963,20532787,20529936,20525191,20516048,20514908,20507411,20506498,20504106,20496042,20492877,20492759,20490291,20489727,20486733,20481654,20477696,20477085,20477007,20472925,20459619,20455343,20448284,20447954,20444750,20437643,20435649,20427296,20421914,20421913,20419647,20413687,20412708,20412706,20412566,20398340,20398005,20398002,20390117,20374638,20363657,20353751,20353370,20349065,20346179,20339519,20332595,20237123,20213090,20205872,20196860,20196859,20195532,20195397,20193265,20191882,20191470,20190998,20186112,20186043,20182576,20171764,20165593,20157432,20154605,20154284,20144929,20140091,20131283,20130803,20130772,20130738,20128110,20113244,20108756,20107564,20105325,20105279,20103603,20097592,20090569,20088913,20082236,20074482,20063189,20032226,20032102,20016797,20012868,20012622,20003278,19999316,19998010,19968863,19957798,19956587,19955995,19946450,19938189,19936085,19935369,19930661,19928400,19918315,19917950,19916579,19915763,19914365,19912216,19909548,19902173,19889479,19886992,19886977,19877724,19862529,19852747,19851470,19844717,19832990,19830230,19823837,19808132,19807535,19804686,19798416,19777175,19770782,19765455,19756665,19754423,19753838,19751817,19746533,19738515,19730911,19727916,19715969,19707464,19707430,19707407,19707357,19707351,19702529,19701735,19693272,19689281,19686597,19672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Results by year

Year	Number of Results
1975	1
1998	3
1999	1
2000	5
2001	89
2002	93
2003	106
2004	144
2005	154
2006	153
2007	157
2008	143
2009	207
2010	182
2011	220
2012	113
2013	4
2014	5
2015	7
2016	2
2017	2
2018	2
2020	1
2021	1
2024	0

1,651 results

Page of 166

Results by year

Page 1

Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury.

Shimizu Y, Sasaki T, Yonekawa E, Yamazaki H, Ogura R, Watanabe M, Hosaka T, Shizu R, Takeshita JI, Yoshinari K. Shimizu Y, et al. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167. J Toxicol Sci. 2021. PMID: 33814510 Free article.

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Harding SD, Faccenda E, Southan C, Pawson AJ, Maffia P, Alexander SPH, Davenport AP, Fabbro D, Levi-Schaffer F, Spedding M, Davies JA. Harding SD, et al. Immunology. 2020 May;160(1):10-23. doi: 10.1111/imm.13175. Epub 2020 Mar 2. Immunology. 2020. PMID: 32020584 Free PMC article. Review.

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.

Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M, Pávek P. Carazo A, et al. Front Pharmacol. 2018 Oct 11;9:993. doi: 10.3389/fphar.2018.00993. eCollection 2018. Front Pharmacol. 2018. PMID: 30364229 Free PMC article.

Mitochondrial dysfunction induced by leflunomide and its active metabolite.

Xuan J, Ren Z, Qing T, Couch L, Shi L, Tolleson WH, Guo L. Xuan J, et al. Toxicology. 2018 Mar 1;396-397:33-45. doi: 10.1016/j.tox.2018.02.003. Epub 2018 Feb 8. Toxicology. 2018. PMID: 29427785 Free PMC article.

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells.

Ren Z, Chen S, Qing T, Xuan J, Couch L, Yu D, Ning B, Shi L, Guo L. Ren Z, et al. Toxicology. 2017 Dec 1;392:11-21. doi: 10.1016/j.tox.2017.10.002. Epub 2017 Oct 5. Toxicology. 2017. PMID: 28988120 Free PMC article.

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD. Aleo MD, et al. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4. Chem Res Toxicol. 2017. PMID: 28437613

Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis.

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Tetrandrine ameliorates collagen-induced arthritis in mice by restoring the balance between Th17 and Treg cells via the aryl hydrocarbon receptor.

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Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner.

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An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.

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