Copper effect on liver cell line: dose response and time course
Summary:
Analysis of HepG2 liver cells treated with up to 600 uM copper sulfate for up to 24 hours. Copper is an essential trace element but can be extremely toxic at supraphysiological levels. Results provide insight into the molecular basis of copper toxicity.
GPL6087:
Agilent-012097 Human 1A Microarray (V2) G4110B - alternative version
Citations:
Song MO, Li J, Freedman JH. Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics 2009 Aug 7;38(3):386-401. PMID: 19549813
McElwee MK, Song MO, Freedman JH. Copper activation of NF-kappaB signaling in HepG2 cells. J Mol Biol 2009 Nov 13;393(5):1013-21. PMID: 19747488
