Abstract
New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Benzimidazoles / chemistry
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Benzimidazoles / pharmacology*
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Blood
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Humans
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Hydrolysis
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Magnetic Resonance Spectroscopy
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Proton Pump Inhibitors / chemistry
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Proton Pump Inhibitors / pharmacology*
Substances
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Benzimidazoles
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Prodrugs
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Proton Pump Inhibitors