Abstract
A novel one pot synthesis of pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyzed via both of heterogeneous and homogeneous catalysis in water, is reported.
Keywords:
green synthesis; in water reaction; multi-component reaction; pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-diones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Acetoacetates / chemistry
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Aldehydes / chemistry
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Barbiturates / chemistry
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Catalysis*
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Hydrazines / chemistry
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrimidines / chemical synthesis
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Pyrimidines / chemistry*
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Water / chemistry*
Substances
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Acetates
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Acetoacetates
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Aldehydes
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Barbiturates
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Hydrazines
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Pyrazoles
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Pyrimidines
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Water
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hydrazine
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pyrazole
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ethyl acetoacetate
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ammonium acetate
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barbituric acid