Lignin Nanosphere-Supported Cuprous Oxide as an Efficient Catalyst for Huisgen [3+2] Cycloadditions under Relatively Mild Conditions

In this work, low-cost lignin nanospheres were fabricated and further applied as an efficient and sustainable support for preparing cuprous oxide (Cu₂O) "green" catalyst by using electrospraying technology. The unalloyed lignin, a special three-dimensional molecular structure, was successfully processed into uniform nanospheres under an electrospraying condition. The synthesized lignin-supported Cu₂O catalyst had a well-defined nanosphere structure, and Cu₂O nanoparticles with sizes less than 30 nm were supported by exposed layers of lignin nanospheres. There were C⁻O⁻Cu bonds formed between the lignin nanospheres and the metallic nanoparticles. The lignin nanospheres and the lignin nanosphere-supported catalyst werfe characterized by utilizing XRD, SEM, TEM, XPS, EDS, and TGA. The immobilization of Cu₂O nanoparticles on the lignin nanospheres was beneficial for dispersion of the Cu₂O nanoparticles and preventing their aggregation, which could cause catalyst deactivation, which favored the Huisgen [3+2] cycloaddition reaction. The triazole synthesis results indicated that the lignin nanosphere-supported Cu₂O catalyst had a high catalytic performance with 99% yield under solvent-free conditions. Furthermore, the as-synthesized catalyst could be recycled for four times without significantly losing its catalytic activity.