Abstract
Osteoporosis is one of the most common extraintestinal complications among patients suffering from inflammatory bowel diseases. The role of vitamin D and calcium in the prevention of a decreased bone mineral density is well known, although other nutrients, including micronutrients, are also of extreme importance. Despite the fact that zinc, copper, selenium, iron, cadmium, silicon and fluorine have not been frequently discussed with regard to the prevention of osteoporosis, it is possible that a deficiency or excess of the abovementioned elements may affect bone mineralization. Additionally, the risk of malnutrition, which is common in patients with ulcerative colitis or Crohn's disease, as well as the composition of gut microbiota, may be associated with micronutrients status.
Keywords:
Crohn’s disease; bone mineral density; cadmium; colitis; fluorine; inflammatory bowel disease; iron; micronutrients; osteoporosis; selenium; silicon; ulcerative; zinc.
MeSH terms
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Bone Density*
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Cadmium / administration & dosage
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Cadmium / adverse effects
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Cadmium / metabolism
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Calcium / physiology
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Colitis, Ulcerative / complications
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Copper / administration & dosage
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Copper / analysis
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Copper / deficiency
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Crohn Disease / complications
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Female
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Fluorine / administration & dosage
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Fluorine / adverse effects
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Fluorine / pharmacology
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Gastrointestinal Microbiome*
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Humans
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Inflammatory Bowel Diseases / complications*
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Iron Deficiencies
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Iron Overload / complications
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Male
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Malnutrition / complications*
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Micronutrients / administration & dosage
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Micronutrients / blood
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Micronutrients / deficiency*
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Osteoporosis / etiology*
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Osteoporosis / prevention & control
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Risk Factors
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Selenium / administration & dosage
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Selenium / blood
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Selenium / deficiency
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Silicon / administration & dosage
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Vitamin D / physiology
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Zinc / administration & dosage
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Zinc / deficiency
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Zinc / metabolism
Substances
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Micronutrients
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Cadmium
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Vitamin D
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Fluorine
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Copper
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Selenium
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Zinc
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Calcium
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Silicon