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    Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12013, updated on 9-May-2024

    Summary

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    Official Symbol
    Bach1provided by MGI
    Official Full Name
    BTB and CNC homology 1, basic leucine zipper transcription factor 1provided by MGI
    Primary source
    MGI:MGI:894680
    See related
    Ensembl:ENSMUSG00000025612 AllianceGenome:MGI:894680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6230421P05Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human BACH1 (BTB domain and CNC homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.9), large intestine adult (RPKM 9.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bach1 in Genome Data Viewer
    Location:
    16 C3.3; 16 49.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87495842..87530234)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87698954..87733346)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41401 Neighboring gene predicted gene, 22808 Neighboring gene predicted gene, 53917 Neighboring gene STARR-seq mESC enhancer starr_41404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87709451-87709604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87723887-87724040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87727532-87727781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87729167-87729320 Neighboring gene predicted gene, 32925 Neighboring gene predicted gene, 23994 Neighboring gene RIKEN cDNA 2810407A14 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BACH1 regulates erythrophagocytosis and iron-recycling in β-thalassemia. Penglong T, et al. Genes Cells, 2023 Mar. PMID 36565308
    2. Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation. Jia M, et al. Circ Res, 2022 Apr. PMID 35196865
    3. Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages. Pradhan P, et al. Redox Biol, 2022 May. PMID 35189551, Free PMC Article
    4. Bach1 plays an important role in angiogenesis through regulation of oxidative stress. Yusoff FM, et al. Microvasc Res, 2021 Mar. PMID 33373621
    5. BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis. Liu Y, et al. Exp Lung Res, 2021 Feb-Mar. PMID 33238752

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.
      Title: BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.
    2. BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
      Title: BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
    3. BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.
      Title: BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.
    4. CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1.
      Title: CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1.
    5. BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
      Title: BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
    6. BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.
      Title: BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.
    7. Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.
      Title: Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.
    8. BACH1 regulates erythrophagocytosis and iron-recycling in beta-thalassemia.
      Title: BACH1 regulates erythrophagocytosis and iron-recycling in β-thalassemia.
    9. BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.
      Title: BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.
    10. ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling.
      Title: ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-activated transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription regulator protein BACH1
    Names
    BTB and CNC homolog 1
    BTB and CNC homology 1 transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007520.2 → NP_031546.1  transcription regulator protein BACH1

      See identical proteins and their annotated locations for NP_031546.1

      Status: VALIDATED

      Source sequence(s)
      AC164108, AK140903, AK141405
      Consensus CDS
      CCDS28293.1
      UniProtKB/Swiss-Prot
      P97302
      UniProtKB/TrEMBL
      Q3URL4, Q3US24
      Related
      ENSMUSP00000026703.6, ENSMUST00000026703.6
      Conserved Domains (2) summary
      cd14719
      Location:554 → 624
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18277
      Location:7 → 126
      BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87495842..87530234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248939.1 → XP_030104799.1  transcription regulator protein BACH1 isoform X2

      Conserved Domains (1) summary
      cd14719
      Location:272 → 342
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain

    2. XM_006522879.4 → XP_006522942.1  transcription regulator protein BACH1 isoform X1

      See identical proteins and their annotated locations for XP_006522942.1

      UniProtKB/Swiss-Prot
      P97302
      UniProtKB/TrEMBL
      Q3URL4, Q3US24
      Conserved Domains (2) summary
      cd14719
      Location:554 → 624
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18277
      Location:7 → 126
      BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97302.1 GenPept UniProtKB/Swiss-Prot:P97302

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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