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    Shkbp1 Sh3kbp1 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 192192, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Shkbp1provided by MGI
    Official Full Name
    Sh3kbp1 binding protein 1provided by MGI
    Primary source
    MGI:MGI:2385803
    See related
    Ensembl:ENSMUSG00000089832 AllianceGenome:MGI:2385803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sb1; B930062H15Rik
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in lysosome. Orthologous to human SHKBP1 (SH3KBP1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 26.6), spleen adult (RPKM 26.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 15.88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27041553..27055440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27342128..27356015, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28101108-28101366 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28117793-28117976 Neighboring gene predicted gene, 30543 Neighboring gene STARR-positive B cell enhancer ABC_E1726 Neighboring gene STARR-positive B cell enhancer ABC_E1727 Neighboring gene STARR-positive B cell enhancer ABC_E2820 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene STARR-seq mESC enhancer starr_18360 Neighboring gene STARR-positive B cell enhancer ABC_E4908 Neighboring gene STARR-positive B cell enhancer ABC_E2230 Neighboring gene biliverdin reductase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of tumor growth and metastasis in Shkbp1 knockout mice. Liu Q, et al. Cancer Gene Ther, 2022 Jun. PMID 34112919
    2. Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. Chen Y, et al. Neuropharmacology, 2005 Dec. PMID 16054660
    3. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Feng L, et al. Cell Biochem Funct, 2011 Oct. PMID 21830225, Free PMC Article
    4. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Borinstein SC, et al. Cell Signal, 2000 Dec. PMID 11152963
    5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD8 + T-cell number and function are altered by Shkbp1 knockout mediated suppression of tumor growth in mice.
      Title: CD8 + T-cell number and function are altered by Shkbp1 knockout mediated suppression of tumor growth in mice.
    2. Suppression of tumor growth and metastasis in Shkbp1 knockout mice.
      Title: Suppression of tumor growth and metastasis in Shkbp1 knockout mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3KBP1-binding protein 1
    Names
    SETA binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138676.2 → NP_619617.2  SH3KBP1-binding protein 1

      See identical proteins and their annotated locations for NP_619617.2

      Status: VALIDATED

      Source sequence(s)
      BB847999, BC061477
      Consensus CDS
      CCDS21018.1
      UniProtKB/Swiss-Prot
      Q3TUN8, Q6P7W2, Q9ES31
      Related
      ENSMUSP00000003857.7, ENSMUST00000003857.7
      Conserved Domains (1) summary
      cd18393
      Location:18 → 120
      BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27041553..27055440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152797.1 → XP_036008690.1  SH3KBP1-binding protein 1 isoform X3

      Conserved Domains (1) summary
      cd18393
      Location:18 → 120
      BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

    2. XM_017322044.1 → XP_017177533.1  SH3KBP1-binding protein 1 isoform X2

      Conserved Domains (1) summary
      cd18393
      Location:18 → 120
      BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

    3. XM_006539667.2 → XP_006539730.2  SH3KBP1-binding protein 1 isoform X1

      Related
      ENSMUST00000123190.8
      Conserved Domains (1) summary
      cd18393
      Location:18 → 120
      BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

    4. XM_006539668.2 → XP_006539731.1  SH3KBP1-binding protein 1 isoform X4

      Related
      ENSMUST00000132684.8

    RNA

    1. XR_003946420.1 RNA Sequence

    2. XR_881667.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7W2.1 GenPept UniProtKB/Swiss-Prot:Q6P7W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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