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    Dstyk dual serine/threonine and tyrosine protein kinase [ Mus musculus (house mouse) ]

    Gene ID: 213452, updated on 2-May-2024

    Summary

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    Official Symbol
    Dstykprovided by MGI
    Official Full Name
    dual serine/threonine and tyrosine protein kinaseprovided by MGI
    Primary source
    MGI:MGI:1925064
    See related
    Ensembl:ENSMUSG00000042046 AllianceGenome:MGI:1925064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ripk5; C820013G01; A930019K20Rik; C430014H23Rik
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including cellular response to fibroblast growth factor stimulus; positive regulation of kinase activity; and positive regulation of signal transduction. Predicted to act upstream of or within phosphorylation. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.7), ovary adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E4; 1 57.24 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132345127..132394697)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132417389..132466959)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene predicted gene, 57562 Neighboring gene RIKEN cDNA 6030442K20 gene Neighboring gene STARR-seq mESC enhancer starr_02257 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:134373585-134373776 Neighboring gene retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene transmembrane protein 81 Neighboring gene contactin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test. Li K, et al. Int J Clin Exp Pathol, 2014. PMID 25400726, Free PMC Article
    2. RIP5 is a RIP-homologous inducer of cell death. Zha J, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178406
    3. Mutations in DSTYK and dominant urinary tract malformations. Sanna-Cherchi S, et al. N Engl J Med, 2013 Aug 15. PMID 23862974, Free PMC Article
    4. Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice. Kelam N, et al. Int J Mol Sci, 2022 Feb 11. PMID 35216141, Free PMC Article
    5. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Peng J, et al. Biochim Biophys Acta, 2006 Nov-Dec. PMID 17123648, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DSTYK homozygous knockout mice show impaired capabilities of learning and memory.
      Title: DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to fibroblast growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual serine/threonine and tyrosine protein kinase
    Names
    dusty PK
    dusty protein kinase
    receptor interacting protein kinase 5
    receptor-interacting serine/threonine-protein kinase 5
    NP_766104.2
    XP_036019313.1
    XP_036019314.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172516.4 → NP_766104.2  dual serine/threonine and tyrosine protein kinase

      See identical proteins and their annotated locations for NP_766104.2

      Status: VALIDATED

      Source sequence(s)
      AK050542, AK082434, AK082904, AK083696, AK132119, BB749395, CJ110290
      Consensus CDS
      CCDS15285.1
      UniProtKB/Swiss-Prot
      Q3ULK4, Q5EBN5, Q6XUX1, Q8C7D4, Q8C923, Q9CTP7
      UniProtKB/TrEMBL
      A0A087WP69
      Related
      ENSMUSP00000035358.8, ENSMUST00000045110.14
      Conserved Domains (2) summary
      smart00220
      Location:651 → 895
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13975
      Location:649 → 910
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132345127..132394697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163420.1 → XP_036019313.1  dual serine/threonine and tyrosine protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A087WP69
      Conserved Domains (1) summary
      cd13975
      Location:551 → 812
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

    2. XM_036163421.1 → XP_036019314.1  dual serine/threonine and tyrosine protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A087WP69
      Conserved Domains (1) summary
      cd13975
      Location:551 → 812
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

    RNA

    1. XR_387156.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6XUX1.1 GenPept UniProtKB/Swiss-Prot:Q6XUX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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