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    Gdpd4 glycerophosphodiester phosphodiesterase domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 233537, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gdpd4provided by MGI
    Official Full Name
    glycerophosphodiester phosphodiesterase domain containing 4provided by MGI
    Primary source
    MGI:MGI:3606573
    See related
    Ensembl:ENSMUSG00000035582 AllianceGenome:MGI:3606573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921513O04
    Summary
    Predicted to enable metal ion binding activity and phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Orthologous to human GDPD4 (glycerophosphodiester phosphodiesterase domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 4.6) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E1; 7 53.57 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97569151..97698870)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97919944..98049663)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104879154-104879355 Neighboring gene STARR-seq mESC enhancer starr_19606 Neighboring gene STARR-seq mESC enhancer starr_19609 Neighboring gene aquaporin 11 Neighboring gene p21 (RAC1) activated kinase 1 Neighboring gene STARR-seq mESC enhancer starr_19614 Neighboring gene STARR-seq mESC enhancer starr_19615 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene Neighboring gene myosin VIIA Neighboring gene STARR-seq mESC enhancer starr_19616 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105268750-105269051 Neighboring gene calpain 5 Neighboring gene olfactory marker protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Nogusa Y, et al. Gene, 2004 Aug 4. PMID 15276213
    2. Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Fujihara Y, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31455729, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycerophosphodiester phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycerophosphodiester phosphodiesterase domain-containing protein 4
    Names
    glycerophosphodiester phosphodiesterase 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177696.3 → NP_808364.2  glycerophosphodiester phosphodiesterase domain-containing protein 4

      See identical proteins and their annotated locations for NP_808364.2

      Status: VALIDATED

      Source sequence(s)
      AK029527, AK161500
      Consensus CDS
      CCDS52318.1
      UniProtKB/Swiss-Prot
      Q3TT99, Q8BI25
      UniProtKB/TrEMBL
      B2RU67
      Related
      ENSMUSP00000036772.7, ENSMUST00000041860.13
      Conserved Domains (2) summary
      pfam03009
      Location:281 → 528
      GDPD; Glycerophosphoryl diester phosphodiesterase family
      cl14615
      Location:254 → 567
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97569151..97698870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507611.1 → XP_006507674.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X1

      Conserved Domains (1) summary
      cl14615
      Location:254 → 567
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. XM_006507612.2 → XP_006507675.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006507675.1

      Conserved Domains (1) summary
      cl14615
      Location:187 → 500
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    3. XM_006507613.3 → XP_006507676.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006507676.1

      Conserved Domains (1) summary
      cl14615
      Location:187 → 500
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    4. XM_006507614.1 → XP_006507677.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X3

      Conserved Domains (1) summary
      cl14615
      Location:36 → 349
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TT99.1 GenPept UniProtKB/Swiss-Prot:Q3TT99

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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