Serpinb13 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb13provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13provided by MGI
Primary source: MGI:MGI:3042250
See related: Ensembl:ENSMUSG00000048775 AllianceGenome:MGI:3042250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HUR7; PI13; HURPIN; headpin; 5430417G24
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity and negative regulation of keratinocyte apoptotic process. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in cytosol and nuclear speck. Predicted to be active in extracellular space. Orthologous to human SERPINB13 (serpin family B member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward stomach adult (RPKM 1.4) See more
Orthologs: human all
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (106908714..106928925)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (106980984..107001195)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L regulates cell proliferation in mouse and human pancreatic islets
Title: Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L.
clade B serpins help to maintain homeostasis by inducing protective humoral immunity
Title: Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.
results suggest an important role of Cat L regulation by hurpin which might be of clinical relevance in human skin diseases
Title: Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serpin B13

Names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172852.3 → NP_766440.2 serpin B13

See identical proteins and their annotated locations for NP_766440.2

Status: VALIDATED

Source sequence(s)

AK030670, BC117990

Consensus CDS

CCDS15213.1

UniProtKB/Swiss-Prot

Q148S5, Q148S6, Q8CDC0

Related

ENSMUSP00000027564.2, ENSMUST00000027564.8

Conserved Domains (1) summary

cl00137
Location:4 → 389

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...