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    Wfdc8 WAP four-disulfide core domain 8 [ Mus musculus (house mouse) ]

    Gene ID: 277343, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wfdc8provided by MGI
    Official Full Name
    WAP four-disulfide core domain 8provided by MGI
    Primary source
    MGI:MGI:2685552
    See related
    Ensembl:ENSMUSG00000070533 AllianceGenome:MGI:2685552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm706
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Is expressed in epididymis and testis. Orthologous to human WFDC8 (WAP four-disulfide core domain 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 66.5) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 85.22 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164438378..164455545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164596458..164613626, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 6A Neighboring gene epididymal peptidase inhibitor Neighboring gene predicted gene, 25512 Neighboring gene WAP four-disulfide core domain 6B Neighboring gene predicted gene, 24473 Neighboring gene WAP four-disulfide core domain 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2. Sivashanmugam P, et al. Gene, 2003 Jul 17. PMID 12909348
    2. The evolution of a genetic locus encoding small serine proteinase inhibitors. Clauss A, et al. Biochem Biophys Res Commun, 2005 Jul 29. PMID 15950183, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WAP four-disulfide core domain protein 8
    Names
    WAP-type serine protease inhibitor
    putative protease inhibitor WAP8C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080550.3 → NP_001074019.1  WAP four-disulfide core domain protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001074019.1

      Status: VALIDATED

      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS38324.1
      UniProtKB/Swiss-Prot
      Q4KUS1
      Related
      ENSMUSP00000104962.2, ENSMUST00000109338.2
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    2. NM_001276431.2 → NP_001263360.1  WAP four-disulfide core domain protein 8 isoform 3

      See identical proteins and their annotated locations for NP_001263360.1

      Status: VALIDATED

      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS71192.1
      UniProtKB/TrEMBL
      Q4KXB5
      Related
      ENSMUSP00000091911.5, ENSMUST00000094351.11
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:81 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    3. NM_001276432.2 → NP_001263361.1  WAP four-disulfide core domain protein 8 isoform 1

      See identical proteins and their annotated locations for NP_001263361.1

      Status: VALIDATED

      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS71191.1
      UniProtKB/TrEMBL
      A2A5H1
      Related
      ENSMUSP00000104963.2, ENSMUST00000109339.8
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164438378..164455545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499673.4 → XP_006499736.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006499736.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    2. XM_006499671.2 → XP_006499734.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006499734.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    3. XM_006499672.3 → XP_006499735.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006499735.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    4. XM_011239586.2 → XP_011237888.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011237888.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    5. XM_006499675.4 → XP_006499738.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006499738.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    6. XM_006499674.3 → XP_006499737.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006499737.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    7. XM_011239587.1 → XP_011237889.1  WAP four-disulfide core domain protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011237889.1

      UniProtKB/TrEMBL
      A2A5H1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    8. XM_030251695.1 → XP_030107555.1  WAP four-disulfide core domain protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q4KUS1
      Conserved Domains (3) summary
      cd00109
      Location:125 → 178
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00199
      Location:180 → 222
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:79 → 122
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KUS1.1 GenPept UniProtKB/Swiss-Prot:Q4KUS1

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