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    Ovol3 ovo like zinc finger 3 [ Mus musculus (house mouse) ]

    Gene ID: 381867, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ovol3provided by MGI
    Official Full Name
    ovo like zinc finger 3provided by MGI
    Primary source
    MGI:MGI:2388075
    See related
    Ensembl:ENSMUSG00000100512 AllianceGenome:MGI:2388075
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    movo3; Gm1903
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human OVOL3 (ovo like zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 1.6), stomach adult (RPKM 1.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B1; 7 17.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29932722..29937000, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30233297..30237575, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18511 Neighboring gene STARR-positive B cell enhancer ABC_E6531 Neighboring gene STARR-positive B cell enhancer ABC_E6532 Neighboring gene calpain, small subunit 1 Neighboring gene STARR-seq mESC enhancer starr_18512 Neighboring gene STARR-positive B cell enhancer ABC_E4915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene tubulin folding cofactor B Neighboring gene polymerase (RNA) II (DNA directed) polypeptide I Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5 Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:31065285-31065586 Neighboring gene THAP domain containing 8, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. Li B, et al. Genomics, 2002 Sep. PMID 12213202, Free PMC Article
    2. Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions. Kumar A, et al. PLoS One, 2012. PMID 22737237, Free PMC Article
    3. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Li B, et al. Development, 2005 Mar. PMID 15716349, Free PMC Article
    4. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermal cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative transcription factor ovo-like protein 3
    Names
    OVO homolog-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289817.1 → NP_001276746.1  putative transcription factor ovo-like protein 3

      See identical proteins and their annotated locations for NP_001276746.1

      Status: PROVISIONAL

      Source sequence(s)
      AC149067
      Consensus CDS
      CCDS80691.1
      UniProtKB/Swiss-Prot
      D3YYM0
      Related
      ENSMUSP00000140811.2, ENSMUST00000189482.2
      Conserved Domains (3) summary
      sd00017
      Location:71 → 91
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:97 → 119
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:111 → 136
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29932722..29937000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153197.1 → XP_036009090.1  putative transcription factor ovo-like protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D3YYM0
      Conserved Domains (3) summary
      sd00017
      Location:71 → 91
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:97 → 119
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:111 → 136
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YYM0.2 GenPept UniProtKB/Swiss-Prot:D3YYM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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