CCAR1 cell division cycle and apoptosis regulator 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCAR1provided by HGNC
Official Full Name: cell division cycle and apoptosis regulator 1provided by HGNC
Primary source: HGNC:HGNC:24236
See related: Ensembl:ENSG00000060339 MIM:612569; AllianceGenome:HGNC:24236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lymph node (RPKM 17.5), appendix (RPKM 15.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q21.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (68721239..68792377)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (69590457..69661544)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (70480996..70552134)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.
Title: m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma.
Title: Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma.
Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence.
Title: Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence.
RP11284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR6273p/CCAR1.
Title: RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1.
Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKgamma protein enhances the anticancer effect of chemotherapy.
Title: Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy.
MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.
Title: MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.
The results revealed that ZKSCAN1 circular RNA exerted its inhibitive role by competitively binding FMRP, therefore, block the binding between FMRP and beta-catenin-binding protein-cell cycle and apoptosis regulator 1 (CCAR1) mRNA, and subsequently restrain the transcriptional activity of Wnt signaling.
Title: Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.
CCAR1 to be a novel transcriptional cofactor for CAR.
Title: Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation.
High CCAR1 expression tended to be an independent predictor of shorter recurrence-free survival in hepatocellular carcinoma patients after curative hepatectomy.
Title: The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis.
Our data demonstrates that CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells. Moreover, CCAR1 may serve as a diagnostic marker and a potential therapeutic target.
Title: Inhibition of CCAR1, a Coactivator of β-Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of cell division cycle and apoptosis regulator 1 (CCAR1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed
Knockdown of cell division cycle and apoptosis regulator 1 (CCAR1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S1418 (e-PCR)
- UniSTS:9491

RH98330 (e-PCR)
- UniSTS:91327

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle and apoptosis regulator protein 1

Names: cell cycle and apoptosis regulatory protein 1; death inducer with SAP domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282959.2 → NP_001269888.1 cell division cycle and apoptosis regulator protein 1 isoform b

See identical proteins and their annotated locations for NP_001269888.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AK298004, AK299307, AY249140, BC132725, BU617955, DB636717

Consensus CDS

CCDS60547.1

UniProtKB/TrEMBL

A0A0C4DGG8

Related

ENSP00000445254.1, ENST00000543719.5

Conserved Domains (5) summary

smart00513
Location:622 → 655

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:266 → 298

PHA03356; tegument protein UL11; Provisional

pfam14443
Location:467 → 586

DBC1; DBC1

pfam14444
Location:137 → 189

S1-like; S1-like

cl23720
Location:1021 → 1100

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001282960.2 → NP_001269889.1 cell division cycle and apoptosis regulator protein 1 isoform b

See identical proteins and their annotated locations for NP_001269889.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AK299307, AY249140, BC132725, BU617955, DA511293, DB636717

Consensus CDS

CCDS60547.1

UniProtKB/TrEMBL

A0A0C4DGG8

Related

ENSP00000439252.1, ENST00000539539.5

Conserved Domains (5) summary

smart00513
Location:622 → 655

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:266 → 298

PHA03356; tegument protein UL11; Provisional

pfam14443
Location:467 → 586

DBC1; DBC1

pfam14444
Location:137 → 189

S1-like; S1-like

cl23720
Location:1021 → 1100

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_018237.4 → NP_060707.2 cell division cycle and apoptosis regulator protein 1 isoform a

See identical proteins and their annotated locations for NP_060707.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AY249140, BC132725, BU617955, DA511293, DB636717

Consensus CDS

CCDS7282.1

UniProtKB/Swiss-Prot

A0JLT7, A1L4P7, A8K9D4, B4DNP8, B4DRK8, Q32NE3, Q5EBM3, Q5VUP6, Q6PIZ0, Q6X935, Q8IX12, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6

UniProtKB/TrEMBL

A0A0C4DGG8

Related

ENSP00000265872.6, ENST00000265872.11

Conserved Domains (5) summary

smart00513
Location:637 → 670

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:281 → 313

PHA03356; tegument protein UL11; Provisional

pfam14443
Location:482 → 601

DBC1; DBC1

pfam14444
Location:152 → 204

S1-like; S1-like

cl23720
Location:1036 → 1115

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RNA

NR_104262.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AY249140, BC144118, BU617955, DA511293, DB636717

Related

ENST00000630771.2