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    Rpl4 ribosomal protein L4 [ Mus musculus (house mouse) ]

    Gene ID: 67891, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rpl4provided by MGI
    Official Full Name
    ribosomal protein L4provided by MGI
    Primary source
    MGI:MGI:1915141
    See related
    Ensembl:ENSMUSG00000032399 AllianceGenome:MGI:1915141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010004J23Rik
    Summary
    Predicted to enable 5S rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of axon extension. Predicted to be located in several cellular components, including A band; cytosolic ribosome; and rough endoplasmic reticulum. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in 8-cell stage embryo. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 606.0), CNS E11.5 (RPKM 541.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 C; 9 34.54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64080159..64085805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64173387..64178562)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39360 Neighboring gene lactase-like Neighboring gene zwilch kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene small nucleolar RNA, C/D box 16A Neighboring gene predicted gene, 23344 Neighboring gene predicted gene, 22571 Neighboring gene predicted gene, 23136 Neighboring gene predicted gene, 22455 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene ubiquitin carboxyl-terminal esterase L4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large ribosomal protein 4 increases efficiency of viral recoding sequences. Green L, et al. J Virol, 2012 Sep. PMID 22718819, Free PMC Article
    2. Ribosomal protein L4 positively regulates activity of a c-myb proto-oncogene product. Egoh A, et al. Genes Cells, 2010 Aug. PMID 20604807
    3. Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. Dresios J, et al. Proc Natl Acad Sci U S A, 2005 Feb 8. PMID 15684048, Free PMC Article
    4. A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. Dudek J, et al. EMBO J, 2002 Jun 17. PMID 12065409, Free PMC Article
    5. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. Cukier IH, et al. FEBS Lett, 2007 Apr 17. PMID 17408621

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse and human RPL4 enhance MoMLV gag-pol readthrough.
      Title: Large ribosomal protein 4 increases efficiency of viral recoding sequences.
    2. The RPL4 plays an important role in c-myc expression by interacting with c-Myb in response to growth factor and nutritional signals.
      Title: Ribosomal protein L4 positively regulates activity of a c-myb proto-oncogene product.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL4
    Names
    60S ribosomal protein L4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024212.5 → NP_077174.1  large ribosomal subunit protein uL4

      See identical proteins and their annotated locations for NP_077174.1

      Status: VALIDATED

      Source sequence(s)
      AC160118
      Consensus CDS
      CCDS40667.1
      UniProtKB/Swiss-Prot
      Q9CY08, Q9D8E6
      UniProtKB/TrEMBL
      Q564E8
      Related
      ENSMUSP00000034966.8, ENSMUST00000034966.9
      Conserved Domains (1) summary
      PTZ00428
      Location:2 → 352
      PTZ00428; 60S ribosomal protein L4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64080159..64085805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155218.1 → XP_036011111.1  large ribosomal subunit protein uL4 isoform X1

      UniProtKB/Swiss-Prot
      Q9CY08, Q9D8E6
      UniProtKB/TrEMBL
      Q564E8
      Conserved Domains (1) summary
      PTZ00428
      Location:2 → 352
      PTZ00428; 60S ribosomal protein L4; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8E6.3 GenPept UniProtKB/Swiss-Prot:Q9D8E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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