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    Tbc1d13 TBC1 domain family, member 13 [ Mus musculus (house mouse) ]

    Gene ID: 70296, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tbc1d13provided by MGI
    Official Full Name
    TBC1 domain family, member 13provided by MGI
    Primary source
    MGI:MGI:2385326
    See related
    Ensembl:ENSMUSG00000039678 AllianceGenome:MGI:2385326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600014A06Rik
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in intracellular protein transport. Located in cytosol and membrane. Orthologous to human TBC1D13 (TBC1 domain family member 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 43.0), duodenum adult (RPKM 28.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 21.22 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30023742..30042024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30133730..30152014)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein kinase N3 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene reactive oxygen species modulator 1 pseudogene Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7803 Neighboring gene predicted gene, 31080

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Davey JR, et al. Traffic, 2012 Oct. PMID 22762500, Free PMC Article
    2. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Llorian M, et al. Biochem J, 2004 Feb 15. PMID 14640981, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TBC1D13 is a potent inhibitor of insulin-stimulated GLUT4 translocation in adipocytes.
      Title: TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38260

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBC1 domain family member 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146252.4 → NP_666364.1  TBC1 domain family member 13

      See identical proteins and their annotated locations for NP_666364.1

      Status: VALIDATED

      Source sequence(s)
      AL845258
      Consensus CDS
      CCDS15871.1
      UniProtKB/Swiss-Prot
      Q8R3D1
      UniProtKB/TrEMBL
      Q3TZ63
      Related
      ENSMUSP00000048426.6, ENSMUST00000044556.12
      Conserved Domains (1) summary
      smart00164
      Location:32 → 367
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30023742..30042024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498322.3 → XP_006498385.1  TBC1 domain family member 13 isoform X2

      See identical proteins and their annotated locations for XP_006498385.1

      Conserved Domains (1) summary
      smart00164
      Location:28 → 291
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. XM_030252063.1 → XP_030107923.1  TBC1 domain family member 13 isoform X1

      Conserved Domains (1) summary
      smart00164
      Location:65 → 328
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. XM_006498320.3 → XP_006498383.1  TBC1 domain family member 13 isoform X2

      See identical proteins and their annotated locations for XP_006498383.1

      Conserved Domains (1) summary
      smart00164
      Location:28 → 291
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    4. XM_030252065.1 → XP_030107925.1  TBC1 domain family member 13 isoform X4

      Conserved Domains (1) summary
      smart00164
      Location:28 → 186
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    5. XM_017319254.2 → XP_017174743.1  TBC1 domain family member 13 isoform X2

      Conserved Domains (1) summary
      smart00164
      Location:28 → 291
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    6. XM_030252062.1 → XP_030107922.1  TBC1 domain family member 13 isoform X1

      Conserved Domains (1) summary
      smart00164
      Location:65 → 328
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    7. XM_006498321.3 → XP_006498384.1  TBC1 domain family member 13 isoform X2

      See identical proteins and their annotated locations for XP_006498384.1

      Conserved Domains (1) summary
      smart00164
      Location:28 → 291
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    8. XM_030252064.1 → XP_030107924.1  TBC1 domain family member 13 isoform X4

      Conserved Domains (1) summary
      smart00164
      Location:28 → 186
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    9. XM_006498323.5 → XP_006498386.1  TBC1 domain family member 13 isoform X3

      Conserved Domains (1) summary
      smart00164
      Location:40 → 198
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3D1.1 GenPept UniProtKB/Swiss-Prot:Q8R3D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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