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    Tspan15 tetraspanin 15 [ Mus musculus (house mouse) ]

    Gene ID: 70423, updated on 7-May-2024

    Summary

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    Official Symbol
    Tspan15provided by MGI
    Official Full Name
    tetraspanin 15provided by MGI
    Primary source
    MGI:MGI:1917673
    See related
    Ensembl:ENSMUSG00000037031 AllianceGenome:MGI:1917673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tm4sf15; 1110036D12Rik; 2700063A19Rik
    Summary
    Enables enzyme binding activity. Involved in protein maturation. Located in cell surface and tetraspanin-enriched microdomain. Is expressed in hypothalamus ventricular layer and pancreas epithelium. Orthologous to human TSPAN15 (tetraspanin 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 37.0), duodenum adult (RPKM 31.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 32.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62021175..62067055, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62185396..62231276, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 241, member B Neighboring gene STARR-seq mESC enhancer starr_26874 Neighboring gene neurogenin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr10:61645889-61646190 Neighboring gene microRNA 7662 Neighboring gene STARR-seq mESC enhancer starr_26875 Neighboring gene tachykinin receptor 2 Neighboring gene hexokinase 1 Neighboring gene STARR-seq mESC enhancer starr_26881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61802071-61802272 Neighboring gene STARR-positive B cell enhancer ABC_E9791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61803279-61803470 Neighboring gene hexokinase 1, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Seipold L, et al. Cell Mol Life Sci, 2018 Sep. PMID 29520422
    2. The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. Koo CZ, et al. J Biol Chem, 2020 Sep 4. PMID 32111735, Free PMC Article
    3. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
    4. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Shah J, et al. Cell Rep, 2018 Nov 20. PMID 30463011
    5. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
      Title: The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
    2. Data show that tetraspanin15 (Tspan15) is abundantly expressed in brain, where it specifically interacts with endogenous a disintegrin and metalloproteinase 10 (ADAM10).
      Title: In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tetraspanin-enriched microdomain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin-15
    Names
    transmembrane 4 superfamily member 15
    tspan-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197996.2 → NP_932113.2  tetraspanin-15

      See identical proteins and their annotated locations for NP_932113.2

      Status: VALIDATED

      Source sequence(s)
      AC127417, CN455615, CX206586
      Consensus CDS
      CCDS56705.1
      UniProtKB/Swiss-Prot
      C0H5X1, F7BWT7, Q3TA07
      Related
      ENSMUSP00000047029.10, ENSMUST00000047883.11
      Conserved Domains (2) summary
      cd03158
      Location:114 → 231
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:19 → 256
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62021175..62067055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514080.1 → XP_006514143.1  tetraspanin-15 isoform X2

      Conserved Domains (1) summary
      cd03158
      Location:42 → 159
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    2. XM_011243561.3 → XP_011241863.1  tetraspanin-15 isoform X3

      Conserved Domains (1) summary
      cd03158
      Location:18 → 133
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    3. XM_011243560.4 → XP_011241862.1  tetraspanin-15 isoform X1

      Conserved Domains (2) summary
      cd03158
      Location:114 → 209
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:20 → 192
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F7BWT7.2 GenPept UniProtKB/Swiss-Prot:F7BWT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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