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    Trp53rkb transformation related protein 53 regulating kinase B [ Mus musculus (house mouse) ]

    Gene ID: 76367, updated on 12-May-2024

    Summary

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    Official Symbol
    Trp53rkbprovided by MGI
    Official Full Name
    transformation related protein 53 regulating kinase Bprovided by MGI
    Primary source
    MGI:MGI:1914050
    See related
    Ensembl:ENSMUSG00000042854 AllianceGenome:MGI:1914050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRPK; Nori-2; Tp53rk; Tp53rkb; Trp53rk; Trp53tk; mNori-2p; 2810408M09Rik; 4933401B08Rik; 5630401H01Rik
    Summary
    Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in nucleus. Is expressed in central nervous system; forelimb bud; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 2.8) and 28 other tissues See more
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    Genomic context

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    Location:
    2 H3; 2 87.22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166634379..166641412)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166792459..166799492)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1259 Neighboring gene predicted gene, 46777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166571427-166571628 Neighboring gene predicted gene, 31117 Neighboring gene STARR-positive B cell enhancer ABC_E6021 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E10161 Neighboring gene STARR-positive B cell enhancer ABC_E2654 Neighboring gene STARR-seq mESC enhancer starr_06416 Neighboring gene STARR-positive B cell enhancer ABC_E2655 Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. Abe Y, et al. J Biol Chem, 2001 Nov 23. PMID 11546806
    2. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
    3. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC2882

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EKC/KEOPS complex subunit Tp53rkb
    Names
    EKC/KEOPS complex subunit Tp53rk
    TP53-regulating kinase
    Trp53 regulating kinase
    atypical serine/threonine protein kinase Tp53rk
    p53-related protein kinase
    NP_076304.2
    XP_006500434.1
    XP_030108048.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023815.5 → NP_076304.2  EKC/KEOPS complex subunit Tp53rkb

      See identical proteins and their annotated locations for NP_076304.2

      Status: VALIDATED

      Source sequence(s)
      AL591703
      Consensus CDS
      CCDS17090.1
      UniProtKB/Swiss-Prot
      Q91W37, Q99PW4, Q9CZ32
      UniProtKB/TrEMBL
      Q543M9
      Related
      ENSMUSP00000115353.2, ENSMUST00000151826.2
      Conserved Domains (1) summary
      COG3642
      Location:27 → 244
      Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      166634379..166641412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500371.4 → XP_006500434.1  EKC/KEOPS complex subunit Tp53rkb isoform X1

      UniProtKB/Swiss-Prot
      Q91W37, Q99PW4, Q9CZ32
      Conserved Domains (1) summary
      COG3642
      Location:51 → 268
      Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

    2. XM_030252188.2 → XP_030108048.1  EKC/KEOPS complex subunit Tp53rkb isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 141
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PW4.1 GenPept UniProtKB/Swiss-Prot:Q99PW4

    Gene LinkOut

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