Sumo2 small ubiquitin-like modifier 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sumo2provided by RGD
Official Full Name: small ubiquitin-like modifier 2provided by RGD
Primary source: RGD:621761
See related: Ensembl:ENSRNOG00000003661 AllianceGenome:RGD:621761
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smt3A; Smt3h2
Summary: Enables retinoid X receptor binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; positive regulation of protein sumoylation; and protein sumoylation. Located in nucleus. Orthologous to human SUMO2 (small ubiquitin like modifier 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 1102.4), Brain (RPKM 713.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (101270899..101283458, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (100771941..100784503, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (104085401..104097983, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation.
Title: SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation.
These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells.
Title: High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.
Exposure to moderate 30 degrees C hypothermia in rats is sufficient to markedly modify the pattern and subcellular localization of SUMO2/3 in neurons; hypothermia triggers nuclear translocation of the SUMO-conjugating enzyme Ubc9.
Title: Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.
disruption of the retinoic acid receptor alpha gene in the testis resulted in alteration of SUMO-2/3 subcellular localization
Title: Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis.
Studies identified SUMO-2 modification as a novel posttranslational regulatory mechanism controlling the ATRA-dependent RARA subcellular localization and transcription.
Title: Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity.
the effects of silencing SUMO2/3 expression on the cellular transcription pattern and cell proliferation were studied.
Title: Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.
Considering the marked effect of SUMO conjugation on the function of target proteins, it is very likely that the postischemic activation of sumoylation has a significant effect on the fate of neurons exposed to transient ischemia.
Title: Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small ubiquitin-related modifier 2

Names: SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2; SUMO-2; sentrin-2; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133594.2 → NP_598278.1 small ubiquitin-related modifier 2

See identical proteins and their annotated locations for NP_598278.1

Status: VALIDATED

Source sequence(s)

BC078746, CF976332

UniProtKB/Swiss-Prot

P61959

UniProtKB/TrEMBL

F1LN30

Related

ENSRNOP00000044856.3, ENSRNOT00000049609.5

Conserved Domains (1) summary

cd16115
Location:17 → 88

Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins