Homo sapiens complex locus FBXO32, encoding F-box protein 32.
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SUMMARY back to top
RefSeq summary
[FBXO32] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes. [provided by RefSeq].

RefSeq annotates 2 representative transcripts (NM included in AceView variants .a and .c), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 6 spliced variants.

AceView synopsis, each blue text links to tables and details
Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is expressed at very high level, 4.0 times the average gene in this release. The sequence of this gene is defined by 460 GenBank accessions from 409 cDNA clones, some from lung (seen 25 times), skeletal muscle (18), uterus (18), brain (17), stomach (14), breast (13), breast normal (13) and 119 other tissues. We annotate structural defects or features in 49 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 11 distinct gt-ag introns. Transcription produces 9 different mRNAs, 6 alternatively spliced variants and 3 unspliced forms. There are 3 probable alternative promotors, 3 non overlapping alternative last exons and 6 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 3 cassette exons, overlapping exons with different boundaries.
Note that mRNA .dAug10 was found in vivo, although it is a predicted target of nonsense mediated mRNA decay (NMD).
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant cAug10).
Function: There are 18 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to a disease (Muscular Atrophy). Proteins are expected to have molecular function (protein binding) and to localize in various compartments (cytoplasm, nucleus). Putative protein interactors have been described (EIF3AANDSNORA19, SKP1).
Protein coding potential: 6 spliced mRNAs putatively encode good proteins, altogether 6 different isoforms (6 complete). The remaining 3 mRNA variants (3 unspliced) appear not to encode good proteins.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 8, links to other databases and other names
Map: This gene FBXO32 maps on chromosome 8, at 8q24.13 according to Entrez Gene. In AceView, it covers 43.38 kb, from 124553499 to 124510121 (NCBI 37, August 2010), on the reverse strand.
Links to: the SNP view, gene overviews from Entrez Gene 114907, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as FBXO32, Fbx32, MAFbx, FLJ32424, MGC33610 or LOC114907, wawvorby. It has been described as F-box only protein 32, atrogin 1, atrogin-1, muscle atrophy F-box protein.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene Fbxo32 (e=5 10-69).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene mfb-1 (e=3 10-08), which may contain interesting functional annotation.
The closest A.thaliana genes, according to BlastP, are the AceView genes AT4G12750 (e=0.13), ZTL (e=0.21), AT4G14723 (e=0.71), AT2G36090 (e=0.72), which may contain interesting functional annotation
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
FBXO32 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 92.7 1.26 3.57 5.04 2.90 346 3.57 17.6 4.39 1.55 2.70 28.5 140 185 6.65 1.02 7.13 20.2 1957 18.8 37.6 11.6 9.41 1.26 4.71 9.41 9.41 371 5.79 2.19 2.52 2.19 4.39 2.52 5.04 2.70 1.91 2.19 2.19 2.19 2.05 13.3 30.6 70.2 5.04 2.70 1.91 2.35 3.57 1.10 11.6 1.18 7.13 2.19 35.1 17.6 5.04 28.5 1.78 37.6 17.6 75.3 8.19 2.70 173 3.10 16.4 5.40 1.55 10.1 3.57 75.3 114 3.10 3.10 4.71 40.3 3.10 16.4 5.79 5.79 185 1.78 3.82 4.71 4.71 35.1 75.3 32.8 16.4 5.79 65.5 114 2.19 1.02 5.79 2.52 114 3.57 2.19 0.96 10.8 4.39 106 75.3 7.64 8.78 3.57 20.2 6.65 8.78 6.21 4.10 6.65 7.64 1.78 92.7 2.90 5.79 53.2 1.91 4.71 70.2 14.3 46.3 8.78 8.19 1483 6.21 18.8 1.45 5.04 5.79 16.4 18.8 6.21 1.66 2.05 10.1 65.5 13.3 122 5.40 2.05 4.10 151 5.04 3.82 21.6 1.78 0.89 4.71 10.8 8.19 1.26 4.39 0.96 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene FBXO32 5' 3' encoded on minus strand of chromosome 8 from 124,553,499 to 124,510,121 13072 17658 18262 13147 14541 19897 17270 21416 a [NM] 13072 17658 18262 1138 17270 21416 b 13147 14541 19897 17270 21416 c [NM] 13072 17658 18262 13147 233 d i-u 13072 17658 18262 1149 e 17270 21416 f g-u h-u 1 2kb 0 361 bp exon 361 bp exon 6084 bp [gt-ag] intron 45 GenBank accessions 13027 RNA-seq supporting reads 3401 UHR pooled cells 3241 Brain 2438 Blood 3702 Neuroblastoma 245 Other (also 12782 Primates bodymap) 113 bp exon 1461 bp [gt-ag] intron 53 GenBank accessions 17605 RNA-seq supporting reads 4819 UHR pooled cells 4446 Brain 3442 Blood 4552 Neuroblastoma 346 Other (also 17471 Primates bodymap) 50 bp exon 1200 bp [gt-ag] intron 53 GenBank accessions 18209 RNA-seq supporting reads 4839 UHR pooled cells 4390 Brain 3985 Blood 4650 Neuroblastoma 345 Other (also 16163 Primates bodymap) 93 bp exon 17564 bp [gt-ag] intron 44 GenBank accessions 13103 RNA-seq supporting reads 3200 UHR pooled cells 3647 Brain 2039 Blood 3912 Neuroblastoma 305 Other (also 14262 Primates bodymap) 94 bp exon 857 bp [gt-ag] intron 44 GenBank accessions 14497 RNA-seq supporting reads 3664 UHR pooled cells 3928 Brain 2500 Blood 4120 Neuroblastoma 285 Other (also 14800 Primates bodymap) 185 bp exon 6623 bp [gt-ag] intron 40 GenBank accessions 19857 RNA-seq supporting reads 5393 UHR pooled cells 6196 Brain 1617 Blood 6237 Neuroblastoma 414 Other (also 15335 Primates bodymap) 183 bp exon 1644 bp [gt-ag] intron 58 GenBank accessions 17212 RNA-seq supporting reads 4436 UHR pooled cells 4772 Brain 2627 Blood 5133 Neuroblastoma 244 Other (also 13771 Primates bodymap) 144 bp exon 1141 bp [gt-ag] intron 79 GenBank accessions 21337 RNA-seq supporting reads 5627 UHR pooled cells 6053 Brain 2698 Blood 6665 Neuroblastoma 294 Other (also 20634 Primates bodymap) 352 bp exon 115 accessions, NM_058229.2 some from skeletal muscle (seen 8 times) brain (6), liver (6) lung (6), eye (5) capped 5' end, 16 accessions Validated 3' end, 17 accessions 352 bp exon 308 bp exon 308 bp exon 6084 bp [gt-ag] intron 45 GenBank accessions 13027 RNA-seq supporting reads 3401 UHR pooled cells 3241 Brain 2438 Blood 3702 Neuroblastoma 245 Other (also 12782 Primates bodymap) 113 bp exon 1461 bp [gt-ag] intron 53 GenBank accessions 17605 RNA-seq supporting reads 4819 UHR pooled cells 4446 Brain 3442 Blood 4552 Neuroblastoma 346 Other (also 17471 Primates bodymap) 50 bp exon 1200 bp [gt-ag] intron 53 GenBank accessions 18209 RNA-seq supporting reads 4839 UHR pooled cells 4390 Brain 3985 Blood 4650 Neuroblastoma 345 Other (also 16163 Primates bodymap) 93 bp exon 25323 bp [gt-ag] intron 2 GenBank accessions 1136 RNA-seq supporting reads 205 UHR pooled cells 428 Brain 126 Blood 356 Neuroblastoma 21 Other (also 117 Primates bodymap) 183 bp exon 1644 bp [gt-ag] intron 58 GenBank accessions 17212 RNA-seq supporting reads 4436 UHR pooled cells 4772 Brain 2627 Blood 5133 Neuroblastoma 244 Other (also 13771 Primates bodymap) 144 bp exon 1141 bp [gt-ag] intron 79 GenBank accessions 21337 RNA-seq supporting reads 5627 UHR pooled cells 6053 Brain 2698 Blood 6665 Neuroblastoma 294 Other (also 20634 Primates bodymap) 5581 bp exon 256 accessions, some from lung (seen 15 times) stomach (13), ovary (12) uterus (12), breast (10) Validated 3' end, 3 accessions Validated 3' end, 17 accessions 5581 bp exon 251 bp exon 251 bp exon 120 bp uORF 251 bp exon 17564 bp [gt-ag] intron 44 GenBank accessions 13103 RNA-seq supporting reads 3200 UHR pooled cells 3647 Brain 2039 Blood 3912 Neuroblastoma 305 Other (also 14262 Primates bodymap) 94 bp exon 94 bp exon 94 bp exon 857 bp [gt-ag] intron 44 GenBank accessions 14497 RNA-seq supporting reads 3664 UHR pooled cells 3928 Brain 2500 Blood 4120 Neuroblastoma 285 Other (also 14800 Primates bodymap) 185 bp exon 185 bp exon 6623 bp [gt-ag] intron 40 GenBank accessions 19857 RNA-seq supporting reads 5393 UHR pooled cells 6196 Brain 1617 Blood 6237 Neuroblastoma 414 Other (also 15335 Primates bodymap) 183 bp exon 183 bp exon 1644 bp [gt-ag] intron 58 GenBank accessions 17212 RNA-seq supporting reads 4436 UHR pooled cells 4772 Brain 2627 Blood 5133 Neuroblastoma 244 Other (also 13771 Primates bodymap) 144 bp exon 144 bp exon 1141 bp [gt-ag] intron 79 GenBank accessions 21337 RNA-seq supporting reads 5627 UHR pooled cells 6053 Brain 2698 Blood 6665 Neuroblastoma 294 Other (also 20634 Primates bodymap) 344 bp exon 344 bp exon 8 accessions, NM_148177.1 some from testis (seen 4 times) hippocampus (once) Validated 3' end, 2 accessions 344 bp exon 291 bp exon 291 bp exon 6084 bp [gt-ag] intron 45 GenBank accessions 13027 RNA-seq supporting reads 3401 UHR pooled cells 3241 Brain 2438 Blood 3702 Neuroblastoma 245 Other (also 12782 Primates bodymap) 113 bp exon 1461 bp [gt-ag] intron 53 GenBank accessions 17605 RNA-seq supporting reads 4819 UHR pooled cells 4446 Brain 3442 Blood 4552 Neuroblastoma 346 Other (also 17471 Primates bodymap) 50 bp exon 1200 bp [gt-ag] intron 53 GenBank accessions 18209 RNA-seq supporting reads 4839 UHR pooled cells 4390 Brain 3985 Blood 4650 Neuroblastoma 345 Other (also 16163 Primates bodymap) 93 bp exon 17564 bp [gt-ag] intron 44 GenBank accessions 13103 RNA-seq supporting reads 3200 UHR pooled cells 3647 Brain 2039 Blood 3912 Neuroblastoma 305 Other (also 14262 Primates bodymap) 282 bp exon 282 bp exon 669 bp [gt-ag] intron 1 GenBank accession 232 RNA-seq supporting reads 111 UHR pooled cells 12 Brain 46 Blood 61 Neuroblastoma 2 Other (also 5 Primates bodymap) 1 accession from t-lymphocytes 109 bp exon 318 bp exon 318 bp exon 1 accession from breast 318 bp exon 292 bp exon 292 bp exon 6084 bp [gt-ag] intron 45 GenBank accessions 13027 RNA-seq supporting reads 3401 UHR pooled cells 3241 Brain 2438 Blood 3702 Neuroblastoma 245 Other (also 12782 Primates bodymap) 113 bp exon 1461 bp [gt-ag] intron 53 GenBank accessions 17605 RNA-seq supporting reads 4819 UHR pooled cells 4446 Brain 3442 Blood 4552 Neuroblastoma 346 Other (also 17471 Primates bodymap) 50 bp exon 1200 bp [gt-ag] intron 53 GenBank accessions 18209 RNA-seq supporting reads 4839 UHR pooled cells 4390 Brain 3985 Blood 4650 Neuroblastoma 345 Other (also 16163 Primates bodymap) 93 bp exon 4643 bp [gt-ag] intron 5 GenBank accessions 1144 RNA-seq supporting reads 831 UHR pooled cells 109 Brain 36 Blood 156 Neuroblastoma 12 Other (also 156 Primates bodymap) 273 bp exon 6 accessions, some from aorta (seen once) brain (once), colon (once) colon tumor, RER+ (once) epidermoid carcinoma cell line (once) 273 bp exon 485 bp exon 485 bp exon 24 bp uORF 485 bp exon 485 bp exon 1644 bp [gt-ag] intron 58 GenBank accessions 17212 RNA-seq supporting reads 4436 UHR pooled cells 4772 Brain 2627 Blood 5133 Neuroblastoma 244 Other (also 13771 Primates bodymap) 144 bp exon 144 bp exon 1141 bp [gt-ag] intron 79 GenBank accessions 21337 RNA-seq supporting reads 5627 UHR pooled cells 6053 Brain 2698 Blood 6665 Neuroblastoma 294 Other (also 20634 Primates bodymap) 353 bp exon 353 bp exon 20 accessions, some from pectoral muscle (after mastectomy) (seen 3 times) uterus (3), islets of langerhans (2) lung (2), muscle (2) Validated 3' end, 4 accessions 353 bp exon 830 bp exon 830 bp exon 830 bp exon Sequence gap 881 bp 16 accessions, some from breast normal (seen 8 times) prostate tumor (6), mammary gland (once) prostate (once), prostatic intraepithelial neoplasia - highgrade (once) capped 5' end, 1 accession 605 bp exon 637 bp exon 637 bp exon 10 accessions, some from carcinoid (seen 2 times) lung (2), 2 pooled high-grade transitional celltumors (once) brain (once), colon (once) Validated 3' end, 1 accession 637 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 1575 bp 355 aa 245 bp 262 bp 2kb including Promoter 38149 bp 1kb
bAug10 6472 bp 262 aa 192 bp 5491 bp 2kb probably including promoter 43325 bp 1kb
cAug10 1201 bp 210 aa 314 bp 254 bp 117 bp 2kb possibly including promoter 29030 bp 1kb
dAug10 938 bp 177 aa 175 bp 229 bp 2kb possibly including promoter 27916 bp 1kb
eAug10 821 bp 134 aa 176 bp 240 bp 2kb possibly including promoter 14209 bp 1kb
fAug10 982 bp 119 aa 359 bp 263 bp 21 bp 2kb possibly including promoter 3767 bp 1kb
gAug10-unspliced 1843 bp 26 aa 16 bp 1746 bp 2kb including Promoter 2316 bp 1kb
hAug10-unspliced 637 bp 47 aa 426 bp 67 bp 2kb 637 bp 1kb
iAug10-unspliced 318 bp 25 aa 103 bp 137 bp 2kb 318 bp 1kb

Gene neighbors and Navigator on chromosome 8q24.13 back to top
WDR67 C R FAM83A D C R P G C C WDYHV1 C I R P R FAM91A1 D C R P FER1L6 D R P C8orf54 R G R C I R P ZHX1andC8orf76 D C R P ATAD2 D C I R P FBXO32 C KLHL38 C I R P ANXA13 100kb 0 dawbly, 2 accessions WDR67, 173 accessions 17 variants FAM83A, 225 accessions 9 variants LOC392266, 1 accession stoyskerbu, 1 accession WDYHV1, 154 accessions 13 variants charvorby, 4 accessions 3 variants FAM91A1, 378 accessions 11 variants FER1L6, 48 accessions 2 variants kluterbo, 1 accession swofoby, 1 accession gowarbu, 1 accession weychoby, 1 accession staskerbu, 1 accession sweefoby, 1 accession povorby, 1 accession parvorby, 1 accession feybeeby, 1 accession pawvorby, 2 accessions gawwarbu, 1 accession poyvorby, 1 accession ryvorby, 1 accession rovorby, 1 accession dufarby, 1 accession fafarby, 1 accession feefarby, 1 accession royvorby, 2 accessions savorby, 1 accession syvorby, 3 accessions ferfarby, 1 accession suvorby, 1 accession seevorby, 1 accession doybly, 2 accessions jorwarbu, 1 accession tavorby, 1 accession garfarby, 1 accession swoskerbu, 1 accession swarskerbu, 3 accessions tarvorby, 1 accession vavorby, 1 accession lawarbu, 1 accession vovorby, 10 accessions neefarby, 1 accession vawvorby, 1 accession vervorby, 1 accession luwarbu, 1 accession sworskerbu, 1 accession swoyskerbu, 1 accession wavorby, 2 accessions lerwarbu, 1 accession fubly, 1 accession leywarbu, 1 accession wuvorby, 1 accession slaskobu, 2 accessions pofarby, 1 accession meewarbu, 1 accession buskeybu, 1 accession wervorby, 1 accession nywarbu, 1 accession syfarby, 1 accession boskeybu, 1 accession zavorby, 1 accession zarvorby, 2 accessions kloterbo, 1 accession kenamu, 2 accessions, 2 variants zoyvorby, 1 accession beeskeybu, 1 accession sufarby, 1 accession berskeybu, 1 accession beyskeybu, 1 accession cheevorby, 1 accession chervorby, 1 accession borskeybu, 1 accession konamu, 1 accession puwarbu, 1 accession siyoya, 1 accession klyterbo, 1 accession nervorby, 1 accession norvorby, 1 accession spoyskerbu, 1 accession kanamu, 1 accession styskerbu, 1 accession puvorby, 2 accessions stuskerbu, 2 accessions stoskerbu, 1 accession kinamu, 2 accessions, 2 variants starskerbu, 1 accession beefarby, 1 accession kunamu, 2 accessions berfarby, 1 accession peevorby, 1 accession pervorby, 1 accession garwarbu, 1 accession peyvorby, 1 accession porvorby, 1 accession gorwarbu, 1 accession stawskerbu, 7 accessions cherger, 2 accessions ruvorby, 1 accession rervorby, 1 accession steeskerbu, 1 accession cherchoby, 5 accessions jawwarbu, 1 accession sterskerbu, 1 accession sovorby, 1 accession sarvorby, 1 accession dorbly, 3 accessions storskerbu, 1 accession swaskerbu, 1 accession servorby, 1 accession shuger, 3 accessions seyvorby, 2 accessions sorvorby, 2 accessions soyvorby, 4 accessions tyvorby, 1 accession kawwarbu, 1 accession kerwarbu, 1 accession fably, 1 accession tawvorby, 1 accession gerfarby, 1 accession teyvorby, 1 accession toyvorby, 1 accession geyfarby, 1 accession vyvorby, 1 accession varvorby, 1 accession veevorby, 1 accession noyfarby, 1 accession vorvorby, 1 accession voyvorby, 2 accessions marwarbu, 2 accessions wovorby, 2 accessions mawwarbu, 1 accession weevorby, 1 accession fobly, 7 accessions nuwarbu, 1 accession reyfarby, 1 accession weyvorby, 1 accession klochoby, 3 accessions vakor, 15 accessions farbly, 12 accessions fawbly, 3 accessions zuvorby, 3 accessions zovorby, 2 accessions zawvorby, 1 accession zeevorby, 2 accessions zeyvorby, 1 accession zorvorby, 1 accession moreya, 1 accession sharger, 2 accessions bawskeybu, 1 accession chavorby, 1 accession chyvorby, 2 accessions chovorby, 1 accession nowarbu, 1 accession cheyvorby, 1 accession boyskeybu, 1 accession choyvorby, 3 accessions suyoya, 1 accession daskeybu, 1 accession shyvorby, 1 accession feebly, 1 accession nerwarbu, 1 accession shuvorby, 1 accession shovorby, 1 accession C8orf54, 12 accessions DERL1, 434 accessions 8 variants deebly, 1 accession LOC100131726, 10 accessions 4 variants ZHX1andC8orf76, 630 accessions 23 variants ATAD2, 305 accessions 18 variants FBXO32, 438 accessions 9 variants KLHL38, 12 accessions ANXA13, 43 accessions 7 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               18 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d, .e, .f, .g-u, .h-u, .i-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !