Homo sapiens complex locus TAP1, encoding transporter 1, ATP-binding cassette, sub-family B (MDR/TAP).
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SUMMARY back to top
RefSeq summary
[TAP1] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq].

RefSeq annotates one representative transcript (NM included in AceView variant.a), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 9 spliced variants.

AceView synopsis, each blue text links to tables and details
Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is expressed at high level, 2.9 times the average gene in this release. The sequence of this gene is defined by 328 GenBank accessions from 291 cDNA clones, some from uterus tumor (seen 17 times), thymus (14), skin (13), lung (12), thalamus (12), t-lymphocytes (11), uterus (11) and 82 other tissues. We annotate structural defects or features in 10 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 14 distinct introns (13 gt-ag, 1 other). Transcription produces 12 different mRNAs, 9 alternatively spliced variants and 3 unspliced forms. There are 6 probable alternative promotors, 4 non overlapping alternative last exons and 5 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of a cassette exon, overlapping exons with different boundaries, splicing versus retention of 2 introns. 2628 bp of this gene are antisense to spliced gene PSMB9.aAug10, raising the possibility of regulated alternate expression.
2 variants were isolated in vivo, despite the fact that they are predicted targets of nonsense mediated mRNA decay (NMD).
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant aAug10, cAug10, dAug10).
Function: There are 162 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (OMIM: Bare lymphocyte syndrome, type I; Other sources: Arthritis, Rheumatoid; Bronchiolitis, Viral; Carcinoma, Renal Cell; Chromosome Deletion; Colonic Neoplasms; Coronary Artery Disease; Diabetes Mellitus, Type 1; diabetes, type 1 and 12 others), proposed to participate in pathways (ABC transporters, Antigen processing and presentation, Phagosome, Primary immunodeficiency) and processes (defense response, interspecies interaction between organisms, protection from natural killer cell mediated cytotoxicity, protein transport, transmembrane transport). Proteins are expected to have molecular functions (ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleotide binding, protein heterodimerization activity, protein homodimerization activity, TAP1 binding, transporter activity) and to localize in various compartments (cytoplasm, membrane, mitochondrion, nucleus, plasma membrane and 4 others). Putative protein interactors have been described (COPG, ESR1, HLA-F, HLA-G, HLA_, KRTAP4-12, MDFI, PDIA3, PSMA1ANDCOPB1, PSMB5, PSMB8, TAP2ANDHLA-DOB, TAPBP).
Protein coding potential: 8 spliced and the unspliced mRNAs putatively encode good proteins, altogether 9 different isoforms (6 complete, 1 COOH complete, 2 partial), some containing domains ABC transporter transmembrane region, ABC transporter [Pfam], some transmembrane domains, a coiled coil stretch [Psort2]. The remaining 3 mRNA variants (1 spliced, 2 unspliced; 2 partial) appear not to encode good proteins.
2 isoforms are annotated using as Met a Kozak-compatible non-AUG start, thereby gaining a minimum of 76 amino acids N-terminal to the first AUG.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 6, links to other databases and other names
Map: This gene TAP1 maps on chromosome 6, at 6p21.3 according to Entrez Gene. In AceView, it covers 9.13 kb, from 32822112 to 32812979 (NCBI 37, August 2010), on the reverse strand.
Links to: manual annotations from OMIM_604571, GAD, KEGG_02010, KEGG_04145, KEGG_04612, KEGG_05340, the SNP view, gene overviews from Entrez Gene 6890, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as TAP1, DAAP-57C1.5, APT1, PSF1, ABC17, ABCB2, RING4, TAP1N, D6S114E, FLJ26666, FLJ41500 or TAP1*0102N, LOC6890. It has been described as antigen peptide transporter 1, PSF-1, ABC transporter, MHC 1, peptide supply factor 1, peptide transporter PSF1, peptide transporter TAP1, really interesting new gene 4 protein, ATP-binding cassette sub-family B member 2, transporter associated with antigen processing, peptide transporter involved in antigen processing 1, ATP-binding cassette, sub-family B (MDR/TAP), member 2, transporter, ATP-binding cassette, major histocompatibility complex, 1.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene Tap1 (e=10-97).
The closest C.elegans genes, according to BlastP, are the AceView/WormGenes haf-9 (e=3 10-51), haf-4 (e=2 10-48), which may contain interesting functional annotation.
The closest A.thaliana genes, according to BlastP, are the AceView genes ATTAP2 (e=10-41), ATTAP1 (e=2 10-40), which may contain interesting functional annotation
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
TAP1 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 4.10 122 9.41 6.21 24.8 2.90 49.7 86.5 114 2.19 140 7.64 12.4 12.4 14.3 7.64 70.2 53.2 10.1 12.4 12.4 80.7 18.8 49.7 0.51 1.02 4.39 1.35 15.3 161 80.7 185 24.8 3.82 5.79 140 11.6 5.79 4.71 70.2 3.33 3.57 20.2 10.1 5.04 5.40 122 86.5 32.8 1.91 1.26 8.78 21.6 9.41 5.40 2.05 57.1 49.7 15.3 3.82 1.78 10.8 30.6 2.05 5.40 18.8 2.70 10.1 4.10 40.3 7.64 14.3 6.65 49.7 80.7 75.3 70.2 30.6 1.91 20.2 4.71 2.90 35.1 49.7 4.10 49.7 65.5 7.64 3.10 3.33 3.33 21.6 7.64 3.82 2.70 21.6 65.5 3.82 53.2 40.3 17.6 61.1 21.6 14.3 6.21 80.7 28.5 106 49.7 28.5 3.10 24.8 8.19 49.7 3.82 3.57 3.10 28.5 43.2 26.6 3.33 32.8 7.64 3.82 14.3 8.78 6.65 5.79 75.3 32.8 57.1 7.13 23.2 40.3 8.19 114 24.8 7.64 5.79 2.35 2.90 11.6 8.78 6.21 35.1 4.71 65.5 53.2 10.1 6.21 12.4 3.10 4.39 75.3 57.1 43.2 57.1 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene TAP1 5' 3' encoded on minus strand of chromosome 6 from 32,822,112 to 32,812,979 68359 90134 77552 85236 82246 89523 a [NM] 90134 77552 85236 82246 89523 b 68359 90134 e 85236 82246 89523 c j-u l-u 85236 82246 89523 d 456 77552 f g-u 68359 k 77552 i 82246 h 1 2kb 0 1297 bp exon 1297 bp exon 48 bp uORF 1297 bp exon 1297 bp exon 536 bp [gt-ag] intron 49 GenBank accessions 68310 RNA-seq supporting reads 5479 UHR pooled cells 3704 Brain 33342 Blood 22025 Neuroblastoma 3760 Other (also 10481 Primates bodymap) 115 bp exon 115 bp exon 148 bp [gt-ag] intron 49 GenBank accessions 91848 RNA-seq supporting reads 8696 UHR pooled cells 5622 Brain 41289 Blood 31516 Neuroblastoma 4725 Other (also 15599 Primates bodymap) 131 bp exon 131 bp exon 959 bp [gt-ag] intron 40 GenBank accessions 90094 RNA-seq supporting reads 7644 UHR pooled cells 4976 Brain 47405 Blood 25365 Neuroblastoma 4704 Other (also 11882 Primates bodymap) 206 bp exon 206 bp exon 426 bp [gt-ag] intron 39 GenBank accessions 71397 RNA-seq supporting reads 6815 UHR pooled cells 4354 Brain 35235 Blood 21772 Neuroblastoma 3221 Other (also 7608 Primates bodymap) 198 bp exon 198 bp exon 1201 bp [gt-ag] intron 37 GenBank accessions 77515 RNA-seq supporting reads 8472 UHR pooled cells 5362 Brain 32827 Blood 27534 Neuroblastoma 3320 Other (also 13488 Primates bodymap) 129 bp exon 129 bp exon 149 bp [gt-ag] intron 54 GenBank accessions 87593 RNA-seq supporting reads 8450 UHR pooled cells 5370 Brain 41926 Blood 27715 Neuroblastoma 4132 Other (also 9807 Primates bodymap) 189 bp exon 189 bp exon 559 bp [gt-ag] intron 54 GenBank accessions 85182 RNA-seq supporting reads 8431 UHR pooled cells 5515 Brain 37053 Blood 30746 Neuroblastoma 3437 Other (also 8870 Primates bodymap) 174 bp exon 174 bp exon 243 bp [gt-ag] intron 46 GenBank accessions 82200 RNA-seq supporting reads 7368 UHR pooled cells 5060 Brain 39887 Blood 26938 Neuroblastoma 2947 Other (also 11510 Primates bodymap) 163 bp exon 163 bp exon 308 bp [gt-ag] intron 62 GenBank accessions 80100 RNA-seq supporting reads 8526 UHR pooled cells 5374 Brain 34280 Blood 29423 Neuroblastoma 2497 Other (also 8002 Primates bodymap) 137 bp exon 137 bp exon 1282 bp [gt-ag] intron 79 GenBank accessions 89444 RNA-seq supporting reads 12087 UHR pooled cells 7866 Brain 26432 Blood 39763 Neuroblastoma 3296 Other (also 9087 Primates bodymap) 582 bp exon 582 bp exon 229 accessions, NM_000593.5 some from thymus (seen 13 times) t-lymphocytes (11), thalamus (10) skin (8), uterus (8) Validated 3' end, 21 accessions 582 bp exon 193 bp exon 92 bp [gt-ag] intron 4 GenBank accessions 168 RNA-seq supporting reads 41 UHR pooled cells 27 Brain 35 Blood 33 Neuroblastoma 32 Other (also 23 Primates bodymap) 115 bp exon 115 bp exon 148 bp [gt-ag] intron 49 GenBank accessions 91848 RNA-seq supporting reads 8696 UHR pooled cells 5622 Brain 41289 Blood 31516 Neuroblastoma 4725 Other (also 15599 Primates bodymap) 131 bp exon 959 bp [gt-ag] intron 40 GenBank accessions 90094 RNA-seq supporting reads 7644 UHR pooled cells 4976 Brain 47405 Blood 25365 Neuroblastoma 4704 Other (also 11882 Primates bodymap) 206 bp exon 426 bp [gt-ag] intron 39 GenBank accessions 71397 RNA-seq supporting reads 6815 UHR pooled cells 4354 Brain 35235 Blood 21772 Neuroblastoma 3221 Other (also 7608 Primates bodymap) 198 bp exon 1201 bp [gt-ag] intron 37 GenBank accessions 77515 RNA-seq supporting reads 8472 UHR pooled cells 5362 Brain 32827 Blood 27534 Neuroblastoma 3320 Other (also 13488 Primates bodymap) 129 bp exon 149 bp [gt-ag] intron 54 GenBank accessions 87593 RNA-seq supporting reads 8450 UHR pooled cells 5370 Brain 41926 Blood 27715 Neuroblastoma 4132 Other (also 9807 Primates bodymap) 189 bp exon 559 bp [gt-ag] intron 54 GenBank accessions 85182 RNA-seq supporting reads 8431 UHR pooled cells 5515 Brain 37053 Blood 30746 Neuroblastoma 3437 Other (also 8870 Primates bodymap) 174 bp exon 243 bp [gt-ag] intron 46 GenBank accessions 82200 RNA-seq supporting reads 7368 UHR pooled cells 5060 Brain 39887 Blood 26938 Neuroblastoma 2947 Other (also 11510 Primates bodymap) 163 bp exon 308 bp [gt-ag] intron 62 GenBank accessions 80100 RNA-seq supporting reads 8526 UHR pooled cells 5374 Brain 34280 Blood 29423 Neuroblastoma 2497 Other (also 8002 Primates bodymap) 137 bp exon 1282 bp [gt-ag] intron 79 GenBank accessions 89444 RNA-seq supporting reads 12087 UHR pooled cells 7866 Brain 26432 Blood 39763 Neuroblastoma 3296 Other (also 9087 Primates bodymap) 579 bp exon 5 accessions, some from testis (seen 2 times) cell lines (once), chondrosarcoma (once) lung (once) Validated 3' end, 1 accession 579 bp exon 307 bp exon 307 bp exon 27 bp uORF 307 bp exon 536 bp [gt-ag] intron 49 GenBank accessions 68310 RNA-seq supporting reads 5479 UHR pooled cells 3704 Brain 33342 Blood 22025 Neuroblastoma 3760 Other (also 10481 Primates bodymap) 115 bp exon 115 bp exon 153 bp [gt-ag] intron 1 GenBank accession 98 RNA-seq supporting reads 1 UHR pooled cells 5 Brain 41 Blood 44 Neuroblastoma 7 Other (also 174 Primates bodymap) 126 bp exon 126 bp exon 126 bp exon 959 bp [gt-ag] intron 40 GenBank accessions 90094 RNA-seq supporting reads 7644 UHR pooled cells 4976 Brain 47405 Blood 25365 Neuroblastoma 4704 Other (also 11882 Primates bodymap) 11 accessions, some from uterus tumor (seen 8 times) adenocarcinoma (2), colon (2) 539 bp exon 1551 bp exon 1551 bp exon 126 bp uORF 1551 bp exon 1551 bp exon 559 bp [gt-ag] intron 54 GenBank accessions 85182 RNA-seq supporting reads 8431 UHR pooled cells 5515 Brain 37053 Blood 30746 Neuroblastoma 3437 Other (also 8870 Primates bodymap) 174 bp exon 174 bp exon 243 bp [gt-ag] intron 46 GenBank accessions 82200 RNA-seq supporting reads 7368 UHR pooled cells 5060 Brain 39887 Blood 26938 Neuroblastoma 2947 Other (also 11510 Primates bodymap) 163 bp exon 163 bp exon 308 bp [gt-ag] intron 62 GenBank accessions 80100 RNA-seq supporting reads 8526 UHR pooled cells 5374 Brain 34280 Blood 29423 Neuroblastoma 2497 Other (also 8002 Primates bodymap) 137 bp exon 137 bp exon 1282 bp [gt-ag] intron 79 GenBank accessions 89444 RNA-seq supporting reads 12087 UHR pooled cells 7866 Brain 26432 Blood 39763 Neuroblastoma 3296 Other (also 9087 Primates bodymap) 576 bp exon 576 bp exon 8 accessions, some from thalamus (seen 2 times) uterus tumor (2), liver and spleen (once) nervous tumor (once) spleen (once) Validated 3' end, 1 accession 576 bp exon 572 bp exon 572 bp exon 3 accessions, some from marrow (seen 3 times) 572 bp exon 254 bp exon 4 accessions, some from marrow (seen 3 times) nervous tumor (once) 254 bp exon 367 bp exon 367 bp exon 69 bp uORF 367 bp exon 367 bp exon 149 bp [gt-ag] intron 54 GenBank accessions 87593 RNA-seq supporting reads 8450 UHR pooled cells 5370 Brain 41926 Blood 27715 Neuroblastoma 4132 Other (also 9807 Primates bodymap) 189 bp exon 189 bp exon 559 bp [gt-ag] intron 54 GenBank accessions 85182 RNA-seq supporting reads 8431 UHR pooled cells 5515 Brain 37053 Blood 30746 Neuroblastoma 3437 Other (also 8870 Primates bodymap) 174 bp exon 174 bp exon 243 bp [gt-ag] intron 46 GenBank accessions 82200 RNA-seq supporting reads 7368 UHR pooled cells 5060 Brain 39887 Blood 26938 Neuroblastoma 2947 Other (also 11510 Primates bodymap) 608 bp exon 608 bp exon 608 bp exon 1282 bp [gt-ag] intron 79 GenBank accessions 89444 RNA-seq supporting reads 12087 UHR pooled cells 7866 Brain 26432 Blood 39763 Neuroblastoma 3296 Other (also 9087 Primates bodymap) 32 accessions, some from uterus tumor (seen 6 times) chondrosarcoma (4), lung (4) cell lines (3), colon (3) Validated 3' end, 12 accessions 582 bp exon 37 bp exon 148 bp [gt-ag] intron 49 GenBank accessions 91848 RNA-seq supporting reads 8696 UHR pooled cells 5622 Brain 41289 Blood 31516 Neuroblastoma 4725 Other (also 15599 Primates bodymap) 131 bp exon 1591 bp [gt-ag] intron 1 GenBank accession 455 RNA-seq supporting reads 37 UHR pooled cells 10 Brain 276 Blood 105 Neuroblastoma 27 Other (also 64 Primates bodymap) 198 bp exon 198 bp exon 1201 bp [gt-ag] intron 37 GenBank accessions 77515 RNA-seq supporting reads 8472 UHR pooled cells 5362 Brain 32827 Blood 27534 Neuroblastoma 3320 Other (also 13488 Primates bodymap) 129 bp exon 149 bp [gt-ag] intron 54 GenBank accessions 87593 RNA-seq supporting reads 8450 UHR pooled cells 5370 Brain 41926 Blood 27715 Neuroblastoma 4132 Other (also 9807 Primates bodymap) 1 accession from uterus 177 bp exon 2219 bp exon 2219 bp exon 24 bp uORF 2219 bp exon 2219 bp exon 7 accessions, some from uterus (seen 2 times) hypothalamus (once), liver and spleen (once) prostate (once), small intestine (once) capped 5' end, 1 accession Validated 3' end, 2 accessions 2219 bp exon 171 bp exon 536 bp [gt-ag] intron 49 GenBank accessions 68310 RNA-seq supporting reads 5479 UHR pooled cells 3704 Brain 33342 Blood 22025 Neuroblastoma 3760 Other (also 10481 Primates bodymap) 115 bp exon 115 bp exon 148 bp [gt-ag] intron 49 GenBank accessions 91848 RNA-seq supporting reads 8696 UHR pooled cells 5622 Brain 41289 Blood 31516 Neuroblastoma 4725 Other (also 15599 Primates bodymap) 205 bp exon 1 accession from cerebellum capped 5' end, 1 accession 205 bp exon 292 bp exon 292 bp exon 21 bp uORF 292 bp exon 292 bp exon 1201 bp [gt-ag] intron 37 GenBank accessions 77515 RNA-seq supporting reads 8472 UHR pooled cells 5362 Brain 32827 Blood 27534 Neuroblastoma 3320 Other (also 13488 Primates bodymap) 83 bp exon 83 bp exon 1 accession from epidermis 83 bp exon 312 bp exon 312 bp exon 243 bp [gt-ag] intron 46 GenBank accessions 82200 RNA-seq supporting reads 7368 UHR pooled cells 5060 Brain 39887 Blood 26938 Neuroblastoma 2947 Other (also 11510 Primates bodymap) 254 bp exon 1 accession 254 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 3321 bp 808 aa 519 bp 375 bp 45 bp 2kb possibly including promoter 9132 bp 1kb
bAug10 2214 bp 547 aa 198 bp 372 bp 2kb possibly including promoter 7581 bp 1kb
cAug10 2601 bp 277 aa 1398 bp 369 bp 123 bp 2kb possibly including promoter 4993 bp 1kb
dAug10 1920 bp 234 aa 247 bp 968 bp 66 bp 2kb possibly including promoter 4153 bp 1kb
eAug10 1087 bp 146 aa 646 bp 24 bp 2kb 2735 bp 1kb
fAug10 672 bp 145 aa 237 bp 2kb possibly including promoter 3761 bp 1kb
gAug10-unspliced 2219 bp 122 aa 1623 bp 227 bp 21 bp 2kb including Promoter 2219 bp 1kb
hAug10 566 bp 120 aa 171 bp 32 bp 2kb possibly including promoter 809 bp 1kb
iAug10 375 bp 97 aa 82 bp 18 bp 2kb possibly including promoter 1576 bp 1kb
jAug10-unspliced 572 bp 62 aa 385 bp 2kb 572 bp 1kb
kAug10 491 bp 83 aa 176 bp 63 bp 2kb including Promoter 1175 bp 1kb
lAug10-unspliced 254 bp 64 aa 59 bp 2kb 254 bp 1kb

Gene neighbors and Navigator on chromosome 6p21.3 back to top
HLA-DRA D C I R P HLA-DQA1 D C I R P R R HLA-DQA2 D C I R P PSMB9 D C I R P R BRD2 C I R P HLA-DPB1 D C I R P RPL32P1 P HLA-DPB2 D C R P SLC39A7andHSD17B8 C I R P RING1 C I R P R RPS18 D C I R P B3GALT4 D C I R P PFDN6 C I R P R D C R P BTNL2 D C R P HLA-DRB5 C R P HLA-DRB6 D C I R P HLA-DRB1 D C I R P HLA-DQB1 C R P HLA-DQB2 R D C I R P TAP2andHLA-DOB D C I R P PSMB8 D C I R P TAP1 D C P PPP1R2P1 D C I R P HLA-DMAandHLA-DMB D C I R P HLA-DOA C I R P HLA-DPA1 R P HLA-DPA3 D C I R P COL11A2 D C I R P RXRB C I R P VPS52 C C R P WDR46 C I R P RGL2 D C I R P TAPBP C I R P ZBTB22 D C I R P DAXX 100kb 0 RNF5, 406 accessions, 13 variants HLA-DRA, 394 accessions 5 variants HLA-DQA1, 666 accessions 11 variants glorsnoybu, 8 accessions 2 variants plartoybo, 6 accessions 2 variants HLA-DQA2, 132 accessions 5 variants PSMB9, 299 accessions 19 variants hoyura, 161 accessions 5 variants BRD2, 432 accessions, 24 variants HLA-DPB1, 476 accessions 17 variants RPL32P1, 1 accession HLA-DPB2, 18 accessions 5 variants SLC39A7andHSD17B8, 523 accessions 13 variants RING1, 241 accessions 7 variants tawglyby, 18 accessions 5 variants RPS18, 413 accessions 15 variants B3GALT4, 105 accessions 3 variants PFDN6, 119 accessions 10 variants glarjor, 3 accessions weyvabo, 1 accession koyglyby, 1 accession riyame, 1 accession shoklarbu, 1 accession luglyby, 1 accession cheejor, 3 accessions hukuya, 1 accession snoyspaby, 2 accessions glasnoybu, 1 accession hekuya, 1 accession lerglyby, 1 accession blarklarbu, 1 accession floyklarbu, 1 accession norseeby, 1 accession puseeby, 1 accession stospaby, 9 accessions kloyklarbu, 2 accessions klawfloybu, 1 accession klysnoybu, 1 accession nawglyby, 1 accession nerglyby, 2 accessions rarseeby, 10 accessions sharbloyby, 2 accessions ploklarbu, 1 accession peyglyby, 3 accessions soyseeby, 1 accession poyglyby, 4 accessions plersnoybu, 1 accession rarglyby, 1 accession baspyby, 3 accessions plorsnoybu, 2 accessions rerglyby, 1 accession tuseeby, 14 accessions rorglyby, 1 accession smaklarbu, 1 accession flajaw, 1 accession skysnoybu, 1 accession takuya, 2 accessions serglyby, 2 accessions soyglyby, 3 accessions taglyby, 2 accessions miyame, 1 accession tuglyby, 1 accession muyame, 2 accessions, 2 variants terglyby, 1 accession sperklarbu, 1 accession speyklarbu, 6 accessions zyseeby, 5 accessions cheeseeby, 5 accessions cherseeby, 1 accession zuvabo, 1 accession cheyseeby, 6 accessions vawglyby, 2 accessions tospyby, 4 accessions baklawbu, 1 accession buklawbu, 2 accessions vyspyby, 1 accession shyklarbu, 1 accession laglyby, 1 accession lyglyby, 1 accession sharklarbu, 1 accession leeglyby, 1 accession ruyame, 1 accession nakuya, 1 accession nukuya, 1 accession florklarbu, 1 accession glyklarbu, 1 accession nikuya, 3 accessions kluklarbu, 1 accession kloklarbu, 3 accessions nekuya, 4 accessions floyjey, 2 accessions klerklarbu, 1 accession royame, 2 accessions yayame, 3 accessions pawseeby, 2 accessions nuglyby, 3 accessions porseeby, 1 accession noglyby, 1 accession klawsnoybu, 5 accessions klersnoybu, 1 accession yuyame, 2 accessions, 2 variants neeglyby, 2 accessions neyglyby, 2 accessions pluklarbu, 3 accessions peeglyby, 2 accessions perglyby, 1 accession pleyklarbu, 1 accession porglyby, 2 accessions raglyby, 3 accessions plarsnoybu, 1 accession skyklarbu, 1 accession plawsnoybu, 1 accession roglyby, 1 accession skawklarbu, 1 accession yoyame, 1 accession klajey, 1 accession royglyby, 2 accessions worvabo, 1 accession syglyby, 1 accession dospyby, 1 accession mayame, 4 accessions smawklarbu, 1 accession skosnoybu, 1 accession toseeby, 1 accession seeglyby, 1 accession sorglyby, 1 accession skersnoybu, 1 accession tikuya, 1 accession voyseeby, 1 accession toglyby, 1 accession bybloy, 5 accessions targlyby, 2 accessions teeglyby, 2 accessions slysnoybu, 7 accessions stoyklarbu, 1 accession zeyseeby, 1 accession tuspyby, 2 accessions vuglyby, 2 accessions varglyby, 1 accession slawsnoybu, 5 accessions C6orf10, 33 accessions 9 variants BTNL2, 6 accessions, 5 variants HLA-DRB5, 256 accessions 8 variants HLA-DRB6, 23 accessions 5 variants HLA-DRB1, 416 accessions 13 variants HLA-DQB1, 441 accessions 14 variants HLA-DQB2, 31 accessions 6 variants kleysnoybu, 18 accessions TAP2andHLA-DOB, 421 accessions 16 variants PSMB8, 585 accessions 11 variants TAP1, 314 accessions, 12 variants PPP1R2P1, 5 accessions HLA-DMAandHLA-DMB, 586 accessions 20 variants HLA-DOA, 181 accessions 7 variants HLA-DPA1, 470 accessions 5 variants HLA-DPA3, 5 accessions 2 variants COL11A2, 112 accessions 5 variants RXRB, 393 accessions, 13 variants VPS52, 478 accessions 20 variants skoysnoybu, 1 accession WDR46, 395 accessions 15 variants RGL2, 454 accessions, 25 variants TAPBP, 551 accessions 9 variants ZBTB22, 129 accessions 3 variants DAXX, 596 accessions, 17 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               162 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d, .e, .f, .g-u, .h, .i, .j-u, .k, .l-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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