|
Gene Name |
Map |
Clones |
Description |
| 1 | 1G935 | I;+1.01 | 32 | Essential, spliced coding gene 1G935. |
| 2 | 1I940 | I;+2.76 | 20 | Essential, tubulin-specific chaperone D. |
| 3 | 2O442 | II;+23.28 | 180 | biogenesis protein bop1 homolog. |
| 4 | 3H521 | III;-1.23 | 175 | Essential, apacd-prov protein. |
| 5 | act-2 | V;+2.88 | 819 | Essential, actin, UNCoordinated locomotion unc-92. |
| 6 | act-4 | X;-6.10 | 671 | actin. |
| 7 | act-5 | III;+21.06 | 169 | Essential, actin. |
| 8 | air-1 | V;+1.40 | 30 | Essential, Aurora A kinase, centrosomal protein required for spindle assembly, cell cycle progression and segregation of developmental factors, LEThal let-412. |
| 9 | air-2 | I;+0.56 | 76 | Essential, Aurora B, required for chromosome segregation and cytokinesis, CYtoKinesis defect cyk-6, LEThal let-603, STerile and Uncoordinated stu-7. |
| 10 | ani-1 | III;+16.41 | 52 | Essential, anillin, actin binding protein required for polar body extrusion, cortical ruffling and pseudocleavage; targets septins to the contractile ring. |
| 11 | arx-1 | I;-5.68 | 70 | Essential, actin Related protein 3, 48 kDa subunit of the Arp2/3 complex; required for proper cytokinesis and for embryonic epidermal and endodermal cells migration (ventral enclosure and gastrulation); forms an operon with coatomer alpha subunit and a gene containing bacterial transferase hexapeptide repeats. |
| 12 | bir-1 | V;+3.35 | 84 | Essential, survivin, aurora B kinase complex component required for chromosome segregation and cytokinesis. |
| 13 | bmk-1 | V;+6.27 | 50 | BiMC related Kinesin-5. |
| 14 | btb-13 | II;-11.29 | 89 | BTB (Broad complex/Tramtrack/Bric a brac) domain protein. |
| 15 | bub-1 | I;+1.88 | 157 | Essential, yeast BUB homolog. |
| 16 | car-1 | I;+15.49 | 171 | Essential, putative alpha synuclein binding protein, required for the stability of the cytokinetic furrow, Cytokinesis, Apoptosis, RNA-associated. |
| 17 | ccf-1 | III;+12.19 | 146 | Essential, CAF1 family ribonuclease, CCR4-NOT transcription complex subunit. |
| 18 | cct-1 | II;+0.63 | 367 | Essential, Chaperonin Containing T Complex Protein 1. |
| 19 | cdc-14 | II;-1.11 | 150 | Essential, protein phosphatase, Cell Division Cycle 14, central spindle and midbody component, required for cytokinetic furrow formation. |
| 20 | cdc-25.1 | I;+1.12 | 33 | Essential, cell Division Cycle 25 phosphatase 1; essential for cell division in the germline and the soma, leads to defective early embryogenesis and aneuploidy, abnormal cell LINeage lin-60. |
| 21 | cdc-42 | II;+0.39 | 60 | Essential, Rho GTPase, Cell Division Cycle CDC42 related, required for cytoskeleton organisation and the control of cell polarity. |
| 22 | cfz-2 | V;-9.41 | 30 | Caenorhabditis FriZzled homolog, required for cell migration; interacts with multiple Wnt signaling pathways. |
| 23 | cls-2 | III;+0.07 | 56 | Essential, clasp-2, CLASP family of microtubule-binding proteins. |
| 24 | csc-1 | II;+18.28 | 55 | aurora B kinase complex component required for chromosome segregation and cytokinesis. |
| 25 | csn-2 | I;+0.65 | 89 | Essential, Constitutive photomorphogenic COP9 SigNalosome subunit. |
| 26 | cul-2 | III;+21.05 | 43 | Essential, cullin 2, required for meiotic progression, anteroposterior polarity, cytokinesis and mitotic chromosome condensation and segregation; central component of a cullin-RING ubiquitin-ligase complex, with ZYG-11 as substrate recognition subunit. |
| 27 | cul-3 | V;-20.65 | 0 | Essential, Cullin. |
| 28 | cyk-1 | III;-0.87 | 41 | Essential, required for cytokinesis in embryos family member, CYtoKinesis defect, LEThal let-794. |
| 29 | cyk-4 | III;+21.01 | 56 | Essential, GTPase activating protein, component of the central spindle required, together with its interacting kinesin ZEN-4, for cytokinetic furrow formation. Influences cell division, morphogenesis, polarization of epithelia. Paternally contributed CYK-4/GAP also initiates embryonic polarity, in association with ECT-2/GEF and RHO-1/rhoA, CYtoKinesis defect. |
| 30 | dhc-1 | I;-1.39 | 75 | Essential, dynein heavy chain, required for rotation of the centrosome/nucleus complex, chromosome congression to a well ordered metaphase plate, and for timely initiation of anaphase, LEThal let-354, SPindle Defective spd-4. |
| 31 | dnc-1 | IV;+4.97 | 47 | Essential, ortholog of Glued p150, required for proper spindle assembly, spindle orientation and cleavage plane specification, DyNactin Complex component. |
| 32 | dnc-2 | III;-1.50 | 47 | Essential, dynamitin, DyNactin Complex component. |
| 33 | dylt-1 | I;+1.92 | 10 | DYnein Light chain (Tctex type]. |
| 34 | dyrb-1 | II;+1.19 | 0 | predicted gene dyrb-1, encoding DYnein light chain (RoadBlock type). |
| 35 | egl-20 | IV;+4.73 | 16 | EGg Laying defective, encoding wnt signaling molecule, affects certain cell migrations; expressed in the posterior part of the worm; interacts with frizzled CFZ-2 and LIN-17. |
| 36 | egl-30 | I;-11.75 | 167 | Essential, G protein, class Q, Alpha subunit; activation leads to stimulation of synaptic vesicle exocytosis, thereby antogonizing Galphao, EGg Laying defective. |
| 37 | eif-3.D | III;+0.03 | 303 | Essential, Eukaryotic Initiation Factor. |
| 38 | fox-1 | X;-14.39 | 34 | feminizing gene On X, encoding putative tissue specific splicing regulator, GCAUG binding; X chromosome counting element, contributes to sex determination and dosage compensation, by repressing the male lethal gene xol-1 post-transcriptionally. |
| 39 | gip-1 | III;-15.53 | 39 | Essential, spc98 family protein like, Gamma-tubulin Interacting Protein. |
| 40 | goa-1 | I;+2.12 | 66 | Essential, G protein, class O, Alpha subunit, required for synaptogenesis and centrosome movement; antagonises Galphaq/EGL-30. |
| 41 | gpb-1 | II;+4.80 | 82 | Essential, G Protein, Beta subunit. |
| 42 | gpc-2 | I;+1.41 | 314 | Essential, G Protein, Gamma subunit. |
| 43 | gpr-1 | III;-0.11 | 15 | Essential, G protein regulator required for asymmetric cell division and aster-positioned cytokinesis, G Protein Regulator, Activator of G protein Signalling ags-3.2. |
| 44 | gpr-2 | III;+0.32 | 22 | Essential, GoLoco motif, G Protein Regulator, Activator of G protein Signalling ags-3.3. |
| 45 | gsk-3 | I;+15.04 | 26 | Essential, Glycogen Synthase Kinase 3 beta, ShaGGy (Drosophila) homolog, which has a role in the circadian clock. |
| 46 | gsnl-1 | V;+1.94 | 58 | gelsolin-like protein. |
| 47 | hcp-1 | V;+0.11 | 64 | Essential, myosin heavy chain related, required for chromosome segregation and mitotic spindle checkpoint, HoloCentric chromosome binding Protein. |
| 48 | hcp-2 | V;+2.01 | 52 | Essential, myosin heavy chain related protein, required for chromosome segregation and the mitotic spindle checkpoint, HoloCentric chromosome binding Protein. |
| 49 | hcp-3 | III;+0.59 | 145 | Essential, centromere specific histone H3 variant CENP-A, essential together with KNL-2 and CENP-C/HCP-4 for kinetochore function, spindle assembly and chromosome segregation, HoloCentric chromosome binding Protein. |
| 50 | hcp-4 | I;-2.43 | 65 | Essential, resolution of sister centromeres factor CENP-C, required for the spindle checkpoint; associates to chromatin provided CENP-a/HCP-3 and KNL-2/Myb domain are assembled on chromatin, HoloCentric chromosome binding Protein. |
| 51 | icp-1 | I;-8.74 | 37 | Essential, Inner Centromere Protein homolog required for chromosome segregation and cytokinesis; coexpressed in an operon with tpxl-1. |
| 52 | ima-2 | I;+0.96 | 123 | Essential, IMportin Alpha, member of the Nuclear Localization Sequence receptor protein family. |
| 53 | kin-19 | III;-4.07 | 162 | Essential, casein kinase I alpha. |
| 54 | klp-7 | III;+4.33 | 44 | Essential, MCAK homolog (Kinesin-13) required for meiotic and mitotic spindle function and cytokinesis; microtubule depolymerizing kinesin. |
| 55 | klp-17 | II;+3.99 | 11 | kinesin-like protein. |
| 56 | klp-19 | III;+20.74 | 51 | Essential, kinesin-4, required for chromosome orientation and segregation at mitosis. |
| 57 | let-21 | | 0 | Essential, LEThal. |
| 58 | let-92 | IV;+5.74 | 143 | Essential, protein phosphatase 2A, catalytic subunit; functions in a complex with PAA-1 regulatory A subunit; participates in the centrosomal complex RSA-1/RSA-2/PP2A/SPD-5 and regulates mitotic spindle assembly by controling microtubule stability; suppresses human tau induced and other nervous or muscular Uncoordinated phenotypes, LEThal. |
| 59 | let-99 | IV;+6.93 | 23 | Essential, polarity factor interacting with heterotrimeric G-protein regulators to control orientation of the mitotic spindle, hence cytokinesis, acts downstream of the astral microtubules signal, LEThal. |
| 60 | let-502 | I;-0.86 | 74 | Essential, rho-associated kinase, LEThal. |
| 61 | lfi-1 | X;-6.04 | 168 | lin-5 (Five) Interacting protein, encoding LFI-1. |
| 62 | lin-5 | II;+0.49 | 37 | Essential, abnormal cell LINeage. |
| 63 | lin-17 | I;-6.51 | 568 | abnormal cell LINeage, encoding frizzled protein, regulates certain asymmetric cell divisions; also required to establish neuronal polarity and to regulate axon guidance; receptor of several Wnt, including LIN-44 and EGL-20. |
| 64 | lin-18 | X;-8.83 | 33 | abnormal cell LINeage, encoding tyrosine kinase receptor-related protein precursor RYK. |
| 65 | lin-44 | I;-1.87 | 23 | abnormal cell LINeage, encoding wingless-related MMTV integration site Wnt protein, controls the polarity of certain asymmetric cell divisions. |
| 66 | lis-1 | III;+20.87 | 29 | Essential, human LISsencephaly protein related, required for bipolar spindle assembly, ProNuclear Migration abnormal pnm-1. |
| 67 | mdf-1 | V;+1.96 | 28 | Essential, mitosis arrest deficient 1, component of the spindle-assembly checkpoint, binds to Mitosis arrest DeFicient MDF-2. |
| 68 | mdf-2 | IV;-7.78 | 48 | Essential, component of the spindle-assembly checkpoint, binds to Mitosis Arrest Deficient MDF-1, localises to centrosomes and chromosomes. |
| 69 | mei-1 | I;+2.71 | 125 | Essential, katanin family member, required for meiotic spindle formation, defective MEIosis. |
| 70 | mei-2 | I;+1.22 | 49 | Essential, microtubule severing protein essential for female meiotic spindle function; C-terminal region is similar to katanin p80, defective MEIosis. |
| 71 | mel-11 | II;+1.38 | 70 | Essential, myosin light chain phosphatase, inhibits non muscle myosin NMY-2 contractility; mutants undergo fast cytokinesis, Maternal Effect Lethal. |
| 72 | mel-26 | I;+3.34 | 43 | Essential, speckle-type POZ protein Spop, postmeiotic negative regulator of meiotic-specific spindle component MEI-1, Maternal Effect Lethal. |
| 73 | mel-28 | III;-2.41 | 87 | Essential, protein required for both the structural and functional integrity of the nuclear envelope and for chromatin maintenance; the protein shuttles between the nuclear pore complex and the kinetochore, Maternal Effect Lethal. |
| 74 | mel-43 | IV;+3.67 | 0 | Essential, maternal Effect Lethal. |
| 75 | mes-1 | X;+5.05 | 17 | Essential, receptor protein tyrosine kinase-like family member, Maternal Effect Sterile. |
| 76 | mex-3 | I;-18.54 | 202 | Essential, KH domain protein, embryonic cell fate determinant, Muscle EXcess. |
| 77 | mig-1 | I;-17.56 | 60 | abnormal cell MIGration, encoding Caenorhabditis FriZzled homolog, transmembrane receptor required for cell migration. |
| 78 | mig-5 | II;+0.63 | 109 | Essential, cytoplasmic signalling transducer, abnormal cell MIGration. |
| 79 | mis-12 | I;-3.10 | 14 | Essential, MInichromosome Stability 12 homolog; complexes with KBP-1 and KBP-2; part of the KMN network constituting the core microtubule binding site of the kinetochore. |
| 80 | mlc-4 | III;-7.35 | 42 | Essential, regulatory myosin light chain. |
| 81 | mom-1 | X;-3.42 | 16 | Essential, porcupine related, required for antero posterior embryonic blastomere cell polarity, MOre Mesoderm (additional MS-like pharyngeal tissue). |
| 82 | mom-2 | V;+1.46 | 154 | Essential, wnt secreted glycoprotein required in the early embryo for induction of the endoderm (intestine); contributes to establishment and maintain of embryonic postero-anterior polarisation, MOre Mesoderm (additional MS-like pharyngeal tissue). |
| 83 | mom-3 | II;+19.82 | 12 | Essential, MOre Mesoderm (additional MS-like pharyngeal tissue), LEThal let-553, abnormal cell MIGration mig-14, Protruding VuLva pvl-2. |
| 84 | mom-4 | I;+4.20 | 50 | Essential, protein kinase involved in endoderm specification, MOre Mesoderm (additional MS-like pharyngeal tissue). |
| 85 | mom-5 | I;+4.31 | 15 | MOre Mesoderm (additional MS-like pharyngeal tissue), encoding frizzled homolog. |
| 86 | nmy-2 | I;+2.44 | 119 | non-muscle myosin heavy chain, cytoplasmic, required for the establishment of embryonic polarity, for formation of the cytokinetic furrow and for axonal guidance: mutants have overall defasciculation of the ventral cord; interacts with the serine threonine protein kinase PAR-1. |
| 87 | nop-1 | III;-1.26 | 0 | NO Pseudocleavage. |
| 88 | npp-1 | IV;+4.74 | 42 | Essential, Nuclear Pore complex Protein. |
| 89 | npp-22 | V;+3.43 | 19 | ndc-1. |
| 90 | paa-1 | III;-1.76 | 126 | Essential, phosphatase 2A regulatory A subunit, required for viability, fertility, and a normal vulva; also suppresses human tau induced and other nervous or muscular Uncoordinated phenotypes; binds SMG-5; participates in the centrosomal RSA complex regulating spindle assembly (RSA-1/RSA-2/SPD-5/LET-92/PAA-1. |
| 91 | par-2 | III;-25.10 | 66 | Essential, ring finger protein required for stabilization of embryonic polarity; asymmetrically distributed, abnormal embryonic PARtitioning of cytoplasm. |
| 92 | par-3 | III;-1.63 | 53 | Essential, three-PDZ containing protein; asymmetrically distributed, required for cell polarity and spindle alignment, abnormal embryonic PARtitioning of cytoplasm. |
| 93 | pfd-3 | I;+14.53 | 38 | Essential, molecular chaperone prefoldin 3, Von Hippel-Landau Binding Protein homolog. |
| 94 | pfd-5 | III;-0.76 | 27 | Essential, protein similar to prefoldin chaperone subunit 5 and c-myc binding protein MM1. |
| 95 | pfd-6 | I;+1.91 | 147 | Essential, PreFolDin (molecular chaperone). |
| 96 | pfn-1 | I;+15.59 | 15 | Essential, profilin. |
| 97 | pie-1 | III;+16.25 | 61 | Essential, germline associated transcriptional repressor, embryonic cell fate determinant; inhibits somatic differentiation and blocks phosphorylation of the RNA polymerase II large subunit carboxy-terminal domain, Pharynx and Intestine in Excess. |
| 98 | pkc-3 | II;-1.46 | 128 | Essential, atypical protein kinase C, component of a PDZ-mediated protein complex PAR-6/PAR-3/PKC-3/CDC-42 required for establishing embryonic polarity. |
| 99 | pnm-3 | | 0 | Essential, ProNuclear Migration abnormal. |
| 100 | pnm-4 | III;+14.30 | 0 | Essential, ProNuclear Migration abnormal. |
home page