3IUN


Conserved Protein Domain Family
PreP

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COG1505: PreP 
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
Statistics
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PSSM-Id: 441114
Aligned: 330 rows
Threshold Bit Score: 594.411
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3IUN_A         7 KARlhypvtrqgeqvdhyfgQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAqIPYRAAIKEKLAASWN-YAKEGAPF 85 
WP_011137852   1 -------------------mNPSHDPHAWLESLDSDQAAAWVAEQNARTEGVLDaDPRFAGLKADILAHLRdTRQIPYFA 61 
NP_274873      1 -------------------mKSYPDPYRHFENLDSAETQNFAAEANAETRARFLeNDKARALSDGILAQLQdTRQIPFCQ 61 
WP_014085642   1 --------------------mPDHDPHRWLESLDSPDVTRWVEAQNERTRAQLDaDPRFVPLAADILATLRdTRQIPFFA 60 
WP_077302898   1 --------------------mPTHDPYLWLED-DSAATRAWCAEQQAHTAAQLDaDPRFAALADEVLEHLRdDERVPFVE 59 
WP_089082915   1 -------------------mSHLPDSHLWLESLDDPAVDTWVAAQNKRTQAVLDaDERYAPLRQEILDHLRdTRQIPFFS 61 
WP_002642976   1 ---------------------MFTDKFEYLENLNTSETQNFIHAAQTKTRQQFCqSDYFDKTKQDIISQLQdDKQIPFCQ 59 
WP_027786953   2 SDSfr--------------wPAGADPFRFLEALDSKRARTWVDEQNARTRAALRdDDAYRALTARLAKAYLpRERPVIPT 67 
WP_126983995   1 ---------------------MSADRYAVFENLDAPETSAFAAAEHAQTQAWLEsRPDYEPLRRDILAVLQdEQQIPFCQ 59 
WP_003787309   1 ---------------------MFTDPYQYLENLHASETQKFHQSAHAETLAQFCqSENFHKTKQQITEQLQdERQIPFCQ 59 
3IUN_A        86 REGRYHYFFKNDGLQNQNVLWrQ---Q---EGKP-AEVFLDPNTLSP--DGTTAL-DQLSFSRDGRILAYSLSLAGSDWR 155
WP_011137852  62 EHKGWLYNFHQDEAHPRGIYR-RttlDayrAGSQdWQTVLDIDALADadERDWYLdGVSHCTVRPERALVHLTDGGGDAT 140
NP_274873     62 EHRARMYHFHQDAEYPKGVYR-VctaAtyrSGYPeWKILFSVADFDEllGDDVYLgGVSHLVEQPNRALLTLSKLGSDTA 140
WP_014085642  61 EHAGWLYNFHQDEAHPRGVYR-RttlAayrANAQdWHTVLDLDALAAaeEVDWYLdGVSHYTLQPTRVLLSLTPGGSDAT 139
WP_077302898  60 AHAGWWHHFLQSPAHPRGVYR-RirpDdyrANRDaWEVLFDLDALAAaeGVDWHLaGIDHCTERPARCLLSLSADGGDAA 138
WP_089082915  62 EHAGWLYNFHQDEHHPRGIYR-RttlAdyqAASQqWHTVLDVDAVAAaaGKDWYLdGVAHCTVQPSRVLVHLSEGGGDAS 140
WP_002642976  60 EHRARMYHFHQSAEFPKGIYR-VcsaAtyrAGLPkWQTLFSVADFDAilGDDVYLdGVSHYVEQPEKVLLTLSCSGSDSA 138
WP_027786953  68 RWRDWAYDLWQDDLHPKGLWR-RtrwDdwrAGRPaWETLLDVDALGAeeGESWVFeQDAILYPDGDRALLSLSPGGADAV 146
WP_126983995  60 EHRARMYHFYQSKEFPKGVYR-VcsaAsyrAGLPeWEVLFSVADFDEvlGEDVYLdGVSHYVEQPNRVLLSLSPGGGDAA 138
WP_003787309  60 EHRARMYHFHQSADLPKGVYR-McsaAsyrAGIPdWEILFSVADFDEilGDDVYLdGVSHYVERPELALISLSSQGSDSA 138
3IUN_A       156 EIHLMDVESKQPLETPLKD--VKFSGISWLgn-eGFFYSSYDkPdGSeLSARTDQHKVYFHRLGTAQE-DDRLVFGAIpA 231
WP_011137852 141 VAREYDVETRRWVEDGFNFp-EGKNHIAWRdpdsAFVCPGWK-G-AP-LTRAGYPREVWLVERAADGRhGWTLLFAAPeD 216
NP_274873    141 YTLEVDLEAGELVEGGFHFp-AGKNHVSWRdensVWVCPAWN-E-RQ-LTQSGYPREVWLVERGKSFE-ESLPVYQIGeD 215
WP_014085642 140 VTREYDLEAQAFVAGGFAFp-YGKNHIAWRdldsVFVCPAWE-D-EQ-LSRAGYPREVWLLERGQGWD-AAVPLLKLPeD 214
WP_077302898 139 CLREYDLDARAFVAEGFQLp-PGKHSVTWRdpdsLYAAVVLS-E-AD-ATASGYPREVKLWQRGQPFA-QAHSLLKAErN 213
WP_089082915 141 LAWEYDLETASWVEQGFRFp-HGKNHIAWRdpdsVLVCPGWK-G-AP-LSRSGYPREVWLVERGADGQhQWQQLFVADqD 216
WP_002642976 139 YTLEFDLEKQQIVDGGFHFp-LGKNHVAWRdansVWLCPAWD-E-RQ-LTTSGYPRQVWLMQRGQSLA-EATPVYEMAtD 213
WP_027786953 147 VVREFDLVERRFVDGGFTIdePGHHTVGWIdrdtVYVSWDRG-D-AH-ATAAGYPYEARRWVRGTALA-DAPVVFSGEpD 222
WP_126983995 139 FTLEFDLETRQVVPNGFHFp-AGKNHIAWRdedsVWVCPAWD-E-RQ-LTASGYPREAWLLRRGQSFE-EAQPLLQTAvD 213
WP_003787309 139 YTIEFNLKTGEIVSGGFHFp-LGKNHVAWRdensVWVCPAWD-E-RQ-LTTSGYPRQVWLMQRGQSFD-EATPVYEMDaD 213
3IUN_A       232 QhhryVGATVTED------DRFLLISAANStsgNRLYVKDlsqeNAPLLTVQGDLDADVsLVDnkGSTLYLLTNR----- 300
WP_011137852 217 A----MMTAAWRFlds-dgSAVDLIEASDGfyrKTYHLVDg---GLEAHALPLPAKAEIeAYI--AGDFIVKLAEdwrwr 286
NP_274873    216 G----MMVNAWRYldp-qgSPIDLIEASDGfytKTYLRVSa---EGEAKPLNLPNDCDVvGYL--AGHLLLTLRKdwnra 285
WP_014085642 215 A----MMAAAWRFlda-daTPFDIVEASDSfysKTYYHVAa---DRTLTALPLPPKSEIeAYS--HGDLIVKLADdwnvh 284
WP_077302898 214 A----LAVSAWRMlnpdggEPVDIIEEALSfyrTRYWRVLp---DLSRQALPLPPKVDIdGVV--AGQLIVRLNQaw--- 281
WP_089082915 217 A----MMVAAWRYldg-pdGWLDLIEAADGfysKTYHLIDa---DLQTHPLPLPPKADIeAYL--HGQFIVKLAEdwcwq 286
WP_002642976 214 G----VMASAWRYlda-qgAPLDLIEASTSffhKNYFYVNa---NNQAIKLALPSDCEVvGYL--AGQLMLHLKSdwqrs 283
WP_027786953 223 D----ISAGAGFDp----iDNRHVAWRSVDffdAHAYRLTd---AGEWARYDVPPHVEV-GFW--EGWLMLEPRLdwdcg 288
WP_126983995 214 S----VWVHAWRYlda-qgAPLDLLEESTGffsRRYFQVAs---DGALLPLGLPETCEIcGYL--GGWLLVLLKHdwlra 283
WP_003787309 214 G----VMVSAWRYlda-qgAPLDLIEANTSffqKDYFYVNa---DLAAVKLALPRDCEVvGYL--AGQLFLHLKSdwqrs 283
3IUN_A       301 --DAPNRRLVTVDAAN--PGPAHWRD-LIPERQQVLT-VHSGSGYLFAEYMVDATARVEQFDY----EGK---RVREV-A 366
WP_011137852 287 geAYPSGSLLAVGLPGliGEGPAPQLlQAPAPRLAVAaVETTRSRLLVNLLDNVKSRMLCFAKr---DGAw--ETQPL-A 360
NP_274873    286 nqSYPSGALVAVKLNRgeLG--AAQLlFAPDETQALEsVETTKRFVVASLLENVQGRLKAWRFa---DGKw--QEVEL-P 357
WP_014085642 285 gqQYAAGSLLAVACDAatGQVGRIAAlFEPGERQSVEmVEATLNLLAVIVLDNVKSRLVTLRRa---GGEw--QQCAN-P 358
WP_077302898 282 -gELDAGVLLALDWQAlcAGEIDPLPlFTPGPRQSVDgALAGRSCLFVHVLDEGVSQLWVFTPt---ADGw--QAQRA-P 354
WP_089082915 287 geTHAAGSLLAVPLACllGDAGGIQLlVAPAARLAVEsVETTRSSVVVNLIDNVRSRLQAFDWq---GGSw--HARSL-P 360
WP_002642976 284 kqKYLSGSLIAVKLNKgeLG--EAFClFQPNAHQALElIETTRKFVITSLLDNVSGSLKAWKWe---NSAw--VEQHL-P 355
WP_027786953 289 gvRHAGGSLLAIREQAflAGSRELTTlFAPQPTTSACtWTHTRTTLIASWLDDVHNRTMLWQPrqvdDGTwtwDARPF-E 367
WP_126983995 284 nqSYAAGSLVAVKLNKgvLG--QAQClFAPQAGQSVEgVETTRHFVAATLLDNVSGSLKAWRLq---QGQw--QPAKVpE 356
WP_003787309 284 kqKYVSGSLIAVKLNKgeLG--EAFClFAPTSSQALElIETTRKFVISSLLDNVSGSLKAWKWe---NGAw--VEQAL-P 355
3IUN_A       367 LP--GLGSVSGFNGK-HDDPALYFGFENYAQPPTLYRFEPKSG------AISLYRASAAPFKPEDYVSEQRFYQSKDGTR 437
WP_011137852 361 LP--ADGVIEIADQP-WQSDVLYYSYSDFLTPSGLYRLDLESG------DSECLRRQPEAFDPAPYVAEQWQATAPDGER 431
NP_274873    358 RL--PSGALEMTDQP-WGGDVVYLAASDFTTPLTLFALDLNVM------ELTVMRRQPQQFDSDGINVQQFWTTSADGER 428
WP_014085642 359 LP--QDGVIEFADQP-WQSDVLYYSYSDFLTPAGLYRIDLGGDt-----APEVLRQQPAAFDASAFVAEQWHAAAPDGTA 430
WP_077302898 355 LP--GQGQLEMVDQP-WQSNGLLFGYDDFLTPSTLYWLDADDAt----lAPQALRGQPPRFAAEQMHAQLHHAIAPDGER 427
WP_089082915 361 VP--DSGVIEFADQP-WNSDVLCYSFSDFLTPTGLYRLNVATG------EQDCLRQQPAAFDASGFVAEQCWATASDGVD 431
WP_002642976 356 PF--PKGAIELVDQP-WGGDTVHLAASDFVTPLTLFSLDLNVM------ELTVLRKQPAQFDAQDIAVQQFFAKSADGTR 426
WP_027786953 368 WA--GDAQIDVEPVEsTLNDEVYVDVDTYLDPPECWLADLADRaddassRRVLLDRPPVQFDATGLVVRRASARSQDGTM 445
WP_126983995 357 LPleGAGVLEFADQP-WGGDVLYIAASSFLSPLTLYTLDLQRQ------EWCVMRRQPAQFDPEGVGVQQLHAVSADGER 429
WP_003787309 356 RF--PNGAIELADQP-WGGDTVYLAASDFVTPLTLFALDLNVM------ELTVLRRQPKQFDAQGIVVTQNFATSADGTR 426
3IUN_A       438 VPLIISYRKGL--KLDG----SNPTILYGYGGFDVSLTPSF-SVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQ-N 509
WP_011137852 432 IPYFVVRRRDA--PFDG----ATPTLLYGYGGFEVPMLPYYiENFGPHWLAKGGAFVLACIRGGGEFGPHWHQAAQGP-K 504
NP_274873    429 IPYFHVGKNA-----AP----DMPTLVYAYGGFGIPELPHYlGSIGKYWLEEGNAFVLANIRGGGEFGPRWHQAAQGI-S 498
WP_014085642 431 IPYFVVRLRNL--PFDG----QAPTLLYGYGGFEVPMMPYYmDNFGPQWLEKGGVFAVANIRGGGEFGPAWHQAAQGV-K 503
WP_077302898 428 IPYFVVARRDA--PHDG----QRPTLLYGYGGFAVPMTPFYlGALGRQWLEQGGVFVLSCIRGGGEFGPDWHEAALAE-R 500
WP_089082915 432 IPYFVVRARDT--VFDG----QTPTLLYGYGGFEVPMMPYYvENFGAHWLEKGGAFVLACIRGGGEFGPGWHQAAQGI-K 504
WP_002642976 427 IPYYHVGKTP-----TP----DTPTLVYVYGGFDVPELPHYmGTIGKHWLAKGGAFVLANVRGGGEF-VGWHEAAMRE-N 495
WP_027786953 446 VPYTLIGPRDAldPAEGatrvARPCLLSGYGGFAIPNLPGYsDAFGIGWLERGGVMAFAHIRGGGEFGPRWHVDAQRE-H 524
WP_126983995 430 IPYYYVGNGE------P----NVPALVYAYGGFGVPELPHYlGIIGRHWLAQGGAFVLANIRGGGEFGPAWHAAAQGAaR 499
WP_003787309 427 IPYYHVGKTQ-----SP----DTPTLVYVYGGFAVPELPHYmGAIGRHWLERGGAFVLANVRGGGEF-THWHTAAQRE-N 495
3IUN_A       510 KQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGTGWAYDYGTS 589
WP_011137852 505 RQVSFDDFIAVAEDLIARKLTSPARLAIEGGSNGGLLVGAAMAQRPELFRAVVCEVPLLDMLRYTQLLAGASWIDEYGDP 584
NP_274873    499 KHKSVDDLLAVVRDLSERGISSPEHIGLQGGSNGGLITAAAFVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGNP 578
WP_014085642 504 RAVSFDDFAAVAEDLIARGVTCPRRLGIEGGSNGGLLVGACMVRRPELFHAVVCEVPLLDMLRYTELLAGASWIDEYGDP 583
WP_077302898 501 RQVAFDDFLAIARQLIADGLTCPARLGIQGGSNGGLLVAAAMTQAPELFGAVVCEVPLTDMLRYTELSAGPSWIDEYGDP 580
WP_089082915 505 RPVSFDDFCSVAEALIGSGLTRPDKLGIEGGSNGGLLVAACMVRRPELFKAVVCEVPLLDMLRYTELLAGASWIDEYGDP 584
WP_002642976 496 KHKSVDDLLAVLEDLSTRGFSRPKKIAIQGGSNGGLVVASAFCRQPECMGALVCEVPLTDMLRYTELYAGASWIDEYGDP 575
WP_027786953 525 RQRSFDDFIAVAEDLAATGVTSAAQLGIEGGSNGGLLVAACMVQRPELFGAVLCRVPLLDMRRYPKLHAGAAWLDEYGDP 604
WP_126983995 500 KHKSAEDLVAVAQDLAVRGLSAPERIVLQGGSNGGLVCAAAYCAAPQSIGGMVCEVPLTDMLRYPHLLAGASWQEEYGNP 579
WP_003787309 496 KHKSVDDLLSVINDLVERGYSSAKKIAIQGGSNGGLVVASAFCRLPENLGAMICEVPLTDMLRYTELYAGASWIDEYGDP 575
3IUN_A       590 ADsEAM-FDYLKGYSPLHNVRPGVSYPSTMVTTADHNDRVVPAHSFKFAATLQADnaGPHP-QLIRIETNAGHGA-GTpV 666
WP_011137852 585 DD-EAE-RAALAAYSPYHNLRADARYPLALFTTSASDDRVHPGHARKMAARLLAL--G-HD-ALFYETDGGGHAG-NAgQ 657
NP_274873    579 QK-YEVcKRRLGELSPYHNLSDGIDYPPALITTSLSDDRVHPAHALKFYAKLRET--S-AQ-SWLYSPDGGGHTG-NGtQ 652
WP_014085642 584 ED-PET-RAQLAAYSPYHQVSPEARYPLALFTTSAKDDRVHPAHARKMVARLAEH--G-HD-ALFIETDAGGHSG-NTgQ 656
WP_077302898 581 AD-PEH-YAALAAYSPYQRLQAGVRYPATLVTTSSSDDRVHPGHARKFTARLLAL--G-QP-VQLYQSDAGGHSGqGGdM 654
WP_089082915 585 AD-PQQ-AAALQAYSPYHQLQAAARYPLPLFTTSTRDDRVHPGHARKMVAQMQAL--G-HP-ALLMETDAGGHTG-NAgQ 657
WP_002642976 576 SD-EKI-RDYLTRFSPYHQLDRQKNYPSALMTTSLSDDRVHPAHALKFYAKLAEI--SPET-TWLYAPETGGHTG-NGtQ 649
WP_027786953 605 DD-PHE-GAALAAYSPYHRVREGVAYPPLLLTTSTRDDRVHPAHARKMAARMHAL--G-HErVWYWENTDGGHGS--AdD 677
WP_126983995 580 DT-EPD-RGYLKKLSPYHNLYDGQTYPPTLITTNLSDDRVHPAHALKFHARLREI--G-VK-SRLYAPEAGGHAG-NAsQ 652
WP_003787309 576 AD-PKM-REYLAAFSPYHQLSGSLNYPPAFITTSLSDDRVHPAHALKFYAKLRDN--PNAK-AWLFAPEKGGHTG-NGtQ 649
3IUN_A       667 AKLIEQSADIYAFTLYEMG 685
WP_011137852 658 EDTAAELARVLVYLYQRLC 676
NP_274873    653 RESADELACVLLFLKEFLG 671
WP_014085642 657 QQTAAELARVLVYLYRQLM 675
WP_077302898 655 RQLAAEVARVTVFLYQQLM 673
WP_089082915 658 EQTAAELARVLVYLYQQLM 676
WP_002642976 650 EQSADELACLLAFLTQTIG 668
WP_027786953 678 LERAEADAAEFGFLWAHLG 696
WP_126983995 653 EEVAAELAAVLVFLRQTVG 671
WP_003787309 650 AETAEELAAVFEFLDWAIV 668
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