Conserved Protein Domain Family
Cys_knot

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pfam00007: Cys_knot 
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Cystine-knot domain
The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerisation.
Statistics
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PSSM-Id: 109076
View PSSM: pfam00007
Aligned: 24 rows
Threshold Bit Score: 69.3565
Threshold Setting Gi: 116241320
Created: 11-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QFW_B          6 RPRCRPIN---ATLAVEKEGCPVCITVNTTICAGYCPTMT--RVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVV 80
gi 586132      19 VPMCVPTD---YTLYEERRECDFCVAINTTICMGFCYSRDsnMKELAGPRFLIQRGCTYDQVEYRTVILPGCPLHANPLF 95
gi 585226       5 SYGCHPKN---ISISVES--CGITEFILTTICEGQCYLED--PVYISHD---EQKICNG-DWSYEVKHIEGCPVG----V 69
gi 399830      17 CFGCHLKN---VSIPMER--CGQRVCIHTTICEGLCFSED--AVFESPDEAPEHRVCNG-DWSYEVKHIQGCPES----I 84
gi 2506877   5072 RVPCSTVP---VTTEVSYAGCT--KTVLMNHCSGSCGTFV--MYSAKAQALDHSCSCCKEEKTSQREVVLSCPNGGSLTH 5144
gi 118115     281 GKKCSKTKkspEPVRFTYAGCSSVKKYRPKYC-GSCV---------DGR-------CCTPLQTRTVKMRFRCEDGEMFSK 343
gi 116057     278 GKKCTKTKkspSPVRFTYAGCSSVKKYRPKYC-GSCV---------DGR-------CCTPQQTRTVKIRFRCDDGETFTK 340
gi 116241320  253 GKKCIRTPkisKPIKFELSGCTSMKTYRAKFC-GVCT---------DGR-------CCTPHRTTTLPVEFKCPDGEVMKK 315
gi 121731      29 RYGCRLNN---MTIIVEREDCHG--SITITTCAGLCETTD--LNYQSTWLPRSQGVCNFKEWSYEKVYLEGCPSGVEP-F 100
gi 27806619    18 CRSCELTN---ITITVEKEECGFCISINTTWCAGYCYTRD--LVYRDPARPNIQKTCTFKELVYETVKVPGCAHHADSLY 92
                          90       100       110
                  ....*....|....*....|....*....|..
1QFW_B         81 SYAVALSCQCA--LCRRSTTDCGGPKDHPLTC 110
gi 586132      96 TYPVALSCHCG--TCNTDSDECAHKASSGDGA 125
gi 585226      70 TYPVARNCECT--ACNTGNTYCGRLPGYVPSC 99
gi 399830      85 TYPVATNCYCS--ACNTKDTYCTRLYAHIPSC 114
gi 2506877   5145 TYTHIESCQCQdtVCGLPTGTSRRARRSPRHL 5176
gi 118115     344 NVMMIQSCKCNy-NCPHPNEASFRLYSLFNDI 374
gi 116057     341 SVMMIQSCRCNy-NCPHANEAYPFYRLVNDIH 371
gi 116241320  316 NMMFIKTCACHy-NCPGDNDIFESLYYRKMYG 346
gi 121731     101 FIPVAKSCDCI--KCKTDNTDCDRISMATPSC 130
gi 27806619    93 TYPVATECHCS--KCDSDSTDCTVRGLGPSYC 122
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