Conserved Protein Domain Family
Vpu

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pfam00558: Vpu 
Vpu protein
The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.
Statistics
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PSSM-Id: 109608
View PSSM: pfam00558
Aligned: 16 rows
Threshold Bit Score: 57.7362
Threshold Setting Gi: 139441
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139441    1 MTLL---VGLVLILVGLIAwNICIWGYiikwGYRRYKRHRLE----TEIERLNLILRERAEDSGNESNGEEEErLEQLIH 73
gi 82307110  1 MNLLl--VGIGALIVAFLL-AIVVWTI----AYLEYRKVLKQ----ERINQLYNRLIERAEDSGNESEGEAEE-LAALGE 68
gi 82292156  1 MSDLl-aVTVAAFIVALII-AIVVWTI----VYIEYKKLVRQ----RKINKLFKRIRERAEDS-DESEGDAEE-LAALGE 68
gi 82279668  1 MQSLh-iVAIVALVVAIIL-AIVVWSI----VFIEYRKILRQ----RKIDRLIDRIIERAEDSGNESEGDQEE-LSALVE 69
gi 82280757  1 MHHKd-lLILIVASILLFT-NIVIWTF----ILKKYLEQKEQdrreRELLKRIKRIREVRDDSDYESNGDGGQeVIHLVH 74
gi 82288001  1 MYKDq-iILIIIFCVVFLI-AACIWLF----ILKTYLEQKKQdrreKELLRRLQRIIEIRDDSDYESNGEEEQeVMDLVH 74
gi 82280748  1 MHQRd-lLALIACIFLCLL-NAIFWLF----NLRLYLERRRQdrreREILERIRRIREIGDDSDYESNGEEEQeIMDLVH 74
gi 82282013  1 MIL----IALGCLAIALILlNIFIWRN----LWRLCKQNKLE----VEIENLALRLTERAEDSGNESDGGEEEkLQRLLH 68
gi 82282908  1 MLSMwvaIGLIGIGTLLVI-NIVVWGIvgisVYKRWKRHKEE----QRIIDLIIKITERAEDSGNESDGEDKEtLATLLH 75
gi 82304671  1 MLIWe-qIGLIALGIELII-VIVVWGI----AYKKWREIKEErnrtQRIYNLAERIRIRQEDSGNESNGEEEAqLDNLLH 74
                       90
               ....*....|....*..
gi 139441   74 nynhnNHFANPMFD--L 88
gi 82307110 69 -----VGHLVLGNIhnL 80
gi 82292156 69 -----MGPFIPGDVnnL 80
gi 82279668 70 -----RGHLAPWNIddL 81
gi 82280757 75 t----HGFVNPMFE--L 85
gi 82288001 75 e----HGFVNPMFE--L 85
gi 82280748 75 s----HGFDNPMFE--F 85
gi 82282013 69 dhdnmHGFANPLFD--I 83
gi 82282908 76 n----NGFDNPMFEdrI 88
gi 82304671 75 a----NGFDNPMFDw-P 86
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