Conserved Protein Domain Family
Frizzled

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pfam01534: Frizzled 
Frizzled/Smoothened family membrane region
This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.
Statistics
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PSSM-Id: 396219
View PSSM: pfam01534
Aligned: 86 rows
Threshold Bit Score: 263.317
Threshold Setting Gi: 190618699
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDS39317       193 FFSQSKRiKFSRLWIGLWSGLCAASTLFTILTFFIDI-NRFQYPERPIIFLSMCYFMVAVTYITGLSL-G-NKISCSGPF 269  Echinococcus...
XP_002425290   215 lITKNEY-EQIHKMIGWGATASLFCNLFTVVSFLIEWrSGNKYPAVIIFYINICFLLSNLGWLAQFLPkArEDIVCKKDM 293  human body l...
XP_001842080   239 LFTDHEH-RQIQKLIAWGAGVCLTFNLFTLATFIIDWhNANKYPALVIFYINFCFMVSCLGWLAQFTPgGrEDIVCRKDG 317  southern hou...
KMY87280       244 LYTDDEH-RQIHKLIGWAGSLCLLSNLFVVSTFFIDWkNANKYPAVIVFYINLCFLIACVGWLLQFTSgSrEDIVCRKDG 322  Drosophila s...
XP_001602300   216 LYKPEEE-KQIHSFVFWAAGLCGAFTLFAVVTFLIDWrSANKYPALAVFYINCCFFVNCIGWLAQFLPgSrEVINCRKDG 294  jewel wasp
XP_011054584   224 LYTPDEH-NQIHSFIIWAASICCTFNLFTVLTFVIDWrSANKYPALVIFYINGCFMVSCIGWLIQFTPgSrDVVICHKDG 302  Panamanian l...
XP_001949027   202 LFSMDEH-RQIHNLIAWTATIAGLCNIFAILTFMIEWqSLNRYPNIVILYINICFLFICFGWLSQFWSgTrDDIVCRKNG 280  pea aphid
XP_002411600   152 LLTEDER-LGMRTFVVVVSSIATLTSLFAVLTFMIGWkESRQYPNVMVFYINLCLLLMCVGWLAQFVPgArEDITCRRDG 230  black-legged...
XP_001632182   175 IFSEEEH-TRIHRFVAAFGTLTTVCTLFTVVTFLVGWkSQNRYPSVILFFMNACFCVASVGFLIQFSSdArRKVVCRRDD 253  starlet sea ...
13_pfamImport    1 LFTKKEH-REMHVYIAIFSSVTIFCTFFTLATFLSDWkNSNRYPAVILFYVNACFFVGSIGWLAQFMDgArDEIVCRGDG 79  
CDS39317       270 PPAsfdsaasltskplsisssypilitqgtKFEGCTILFMMLYFFSMAGHIWWVVLTVTWYLaARCHWA---HEAIFRNA 346  Echinococcus...
XP_002425290   294 TLRrsep--------------------saeENLSCVVIFVVIYYFLMAACVWFVIFTYAWHL-SCRGLAk-iQERIDKKG 351  human body l...
XP_001842080   318 TLRssep--------------------sagENLSCIIVFILVYYFLIAAMVWFVIFTYVWHM-SFKAIGkigKDRIDKKG 376  southern hou...
KMY87280       323 TLRhsep--------------------tagENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH---WRAMGh-vQDRIDKKG 378  Drosophila s...
XP_001602300   295 TLRmse----------------------psGDFSCLIVFILVYYSLMAAMVWFVILTYTWLM-SIQALGk-iQGRIDKKS 350  jewel wasp
XP_011054584   303 TLRtre---------------------psgENLSCVIVFVLVYYSLMAAAVWFVILTYAWHM-SFRALGt-iQDRIDKKS 359  Panamanian l...
XP_001949027   281 ARKtse---------------------psdEDLSCVINFVFSYYFLIAAFIWFVIFTYSLHT-TFQSFGk-iQEKVDKKG 337  pea aphid
XP_002411600   231 TLRsgep--------------------ssgENLSCVVIFCLVYYFLLAALCWFVMLTYAWDH-RFQTRAsvpRESLDAKA 289  black-legged...
XP_001632182   254 TMRlgep--------------------tesDSFLCVLTFVLVYYFSLAGMTWFVMLAYSWCI-CFKTLGs-tRDNFAGKT 311  starlet sea ...
13_pfamImport   80 TMRlgep--------------------tlsETVCDVLLLSVVIGLLDSEILVLFVKSVNFNL-TARAFKtkgYRLICGQR 138 
CDS39317       347 QYLHFAAWAIPAAMTICLLAMGK------VDGDPLSGVCFTGLTDPTIVRYFliaPLCISLLLGACFLIAGFVSLFKirt 420  Echinococcus...
XP_002425290   352 AYFHLVAWSLPVVLTITVMASRQ------IDGNSMAGICFVRSSYWGARVVFllvPIAVTILMGGYYLVRGLSFLFN--- 422  human body l...
XP_001842080   377 SYFHLIAWSLPLVLTITIMALSE------IDGNGTVGICFVGYINHPIRGGFllgPVVCVLFIGGYFLGRGLLTLIK--- 447  southern hou...
KMY87280       379 SYFHLVAWSLPLVLTITTMAFSE------VDGNSIVGICFVGYINHSMRAGLllgPLCGVILIGGYFITRGMVMLFG--- 449  Drosophila s...
XP_001602300   351 AYFHLLAWFLPLMLTATIMALGE------IDGNHTTGICFVGYNNHTVRAWFvlaPVLTSLLIGGYFLSRGLILLIR--- 421  jewel wasp
XP_011054584   360 AYFHLIAWCIPLVLTVAIMALGR------IDGNSITGICFVGYADHMAKI-FvlgPILLAVLIGGYFLCRGLYTLIC--- 429  Panamanian l...
XP_001949027   338 GYFHLLAWSIPLVFCVVVMVLGE------IDGDSVTGTCFVGVNNKIYSIIFvliPVLISVLIGLFYLVRVLFGLLA--- 408  pea aphid
XP_002411600   290 AYFHLIAWCVPFVLTITVMALGKashslcVDGDPVSGICFVTSANPIVRSAFvllPVTVAFFVGGYFLVREFYKLIT--- 366  black-legged...
XP_001632182   312 GYFHIISWSLPAVLTGCVLLVKQ------VDANSISGICFVGYKNPSMRAGFllaPLGLDLVIGGMFLAKGLFTLFK--- 382  starlet sea ...
13_pfamImport  139 SDFRSIDGTVYKCLSVDVIKISL------VDGDSVSGICFVGYKNYHYRAGFvlaPIGLVLIVGGYFLIRGVMTLFS--- 209 
CDS39317       421 iIKTGGs-----K-TNDLEKLIFRIGVFSLLYLLPAAVVIACYIYESQKMDRWMLTWyTNEVCRNfdlr----kiaGSSK 490  Echinococcus...
XP_002425290   423 -VKKDSqqilsdKaSAKIREMIVRIGLFSVFCLTFVIVTFMCHIYEFAHEEDWQKSFrNYIFCSIlss------ksDPRD 495  human body l...
XP_001842080   448 -LKISSkeiisaRaSKKIRQTIVRMGICTMLTFVFIVATVFCHIHEFRHAESWALSLkNYIICQIsst-----ytdVTST 521  southern hou...
KMY87280       450 -LKHFAndikstSaSNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWSQSFrQFIICKIssv------feEKSS 522  Drosophila s...
XP_001602300   422 -LKISSqeflqeQaSSKIRETIVRMGLFSLFTLVAVLVTFYCHAYDFEHSSEWKQSFrDYIICSItsk------yaEISD 494  jewel wasp
XP_011054584   430 -LKISSqeiiseRaSSKIKQTIVRMGLFSIGTLAAVVITFYCHIYEIQNSQQWQKSFrSYMICTIask------yaDVSE 502  Panamanian l...
XP_001949027   409 -LKKEStqviskQaKSKIHSAAIKVIMFMILIVVFVSSMFMCYIYEYNNDHLWKDSLrKYIVCKLgii-----pdtDIGN 482  pea aphid
XP_002411600   367 -LKVSNsdvlndRvRTKIQSMILRIGLFVVTMVLLVSCTFVCHIYEFKSQPVWTESLrNYVACRAnvgaaqrflpeEPQS 445  black-legged...
XP_001632182   383 -LRKSNpnflsnRaSIKIKETIMRVGFFAFVAFAFVFITFACHVYEYYNQERWERSYrAFLMCIAnhe-----vkgVSNT 456  starlet sea ...
13_pfamImport  210 -IKSNHpgllseKaASKINETMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFrEYVLCEAnvtia-eqtnkPIPE 287 
CDS39317       491 CiaqlhqilgdtepasstsggdvfDKMDTPTFELFMIKYLMTLIVGITSGIWVWSSKTLHSWHVFFARI 559  Echinococcus multilocul...
XP_002425290   496 C-----------------------QMESRPSIAMIQLHLLIIFAAGIVMSSWVWISSTAETWRRFFNRK 541  human body louse
XP_001842080   522 C-----------------------KLQSRPSVAVLQIHLICLFASGIVMSSWVWTNSTLETWGRYFRRR 567  southern house mosquito
KMY87280       523 C-----------------------RIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKK 568  Drosophila simulans
XP_001602300   495 C-----------------------KKEPRPSAGKLQFHLLSVFFSGILMSHWVWTGSTADTWMRFLRRT 540  jewel wasp
XP_011054584   503 C-----------------------KMDSRPSTGKLQLHLLALFSTGIFMSSWIWTSSTVDTWCRFLRRI 548  Panamanian leafcutter ant
XP_001949027   483 C-----------------------RIEFKPSVSKKQLYILVLFGNAVLMSFWVWTNQIGNAWCECLIRW 528  pea aphid
XP_002411600   446 C-----------------------DPGSRPSLAMLQLHLVAFLGACVALSSWVLTAATAATWKRFWCRY 491  black-legged tick
XP_001632182   457 C-----------------------SIKDRANLSVLELSLSSLFGAGIAMSGWTWTSNTFKTWKKLWHRV 502  starlet sea anemone
13_pfamImport  288 C-----------------------EIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKRAWCRI 333 
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