1OIS


Conserved Protein Domain Family
Topoisom_I_N
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pfam02919: Topoisom_I_N 
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Eukaryotic DNA topoisomerase I, DNA binding fragment
Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. This family may be more than one structural domain.
Links
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Statistics
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PSSM-Id: 427053
Aligned: 119 rows
Threshold Bit Score: 267.037
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1OIS_A                  4 KWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQ-AEEVAGFFAALLE--SD-HAKNP----VFQKNFFNDFLQVLK 75   baker...
Q4N5U3                336 RWKYLEHNGMIFTPEYV--PHNVPIKVKGETIHLPPH-LEEIATMWAQSIG--TN-YETSD----IYCKNFWQVFVSKFE 405  Theil...
XP_001610263          115 HWEYLEHNGMIFTPEYK--PHGIPIKFKGEPITLTPD-LEEVATFWAQSIG--TN-YEESE----IYRRNFWNTFTSMFP 184  Babes...
XP_002907155          137 QWRTLEHNGVMFPPPYQ--PHHVPLLYNGQEIELTPS-QEEVASFYAAIPK--DGpQLGNPktakIFNKNFFTDFKKVLG 211  Phyto...
CBJ32924              367 QWDSLEHNGAHFAPEYK--PHGVKLKYDGKEVHLTTQ-QEEVATFYASMPLdgPQlAEQGK----VFNKNFFTDFKAVLG 439  Ectoc...
XP_004347638          170 RWTTFVHNGPLFPEPYTRLPVNVTFFYDGQPVRMLPDvVEEAVCLFAARLN--SP-LIVNP----KFRLNFIADLNKLVD 242  Capsa...
goetting:Ngar_c04450    2 KWQTLEHKGVAFPPEYQ--PRGIVVTIRGEKLALNRD-QEELIYAWAKKKD--TH-YVQDP----VFQENFMSDLRPLLP 71   Candi...
BAJ47816                3 KWRTLVHNGVALPPPYQ--PKGLSIKIRGETVKLDPL-QEEMAYAWALKKD--TP-YVQDP----VFQKNFLTDFLKTFN 72   Candi...
ABK76827                2 NWKTLQHSGIHFPPEHE--VKGFKIKVKGKQVNLTPL-QEEMAYQWAKKKD--TP-YAQDK----VFQKNFARDFAKELG 71   Cenar...
jgi:Nmar_1322           2 KWKTLQHKGILFPPAYE--AQGIKIKIKGEKVDLNLD-QEEMIYQWAKKKD--TP-YAQDK----VFQKNFTADFAKTLD 71   Nitro...

1OIS_A                 76 ESGgpln--gieI----KEFSRCDFTKMFDYFQLQKEQKK-------QLTSQEKKQI----RLEREKFEEDYKFCELDGR 138  baker...
Q4N5U3                406 KDHf--------Ir--rCKLTDVDFSLIKTHLEDEKQKKK--------DNKEFYKAK----QQEDAKREYRFNYALVDWV 463  Theil...
XP_001610263          185 KGHv--------IrkskATLKDCDFSEIRAHLDMEREKKK--------EQKEYYKAL----KEETAKKEHPYCYALVDWI 244  Babes...
XP_002907155          212 KQHe--------V----KTFDGCDFSRIAAHLEKLREEKK-------NMTKEEKLPE----KEKREMELFTNGFAFVDGH 268  Phyto...
CBJ32924              440 KGHv--------I----KDFKLLDFSAIRAHLDITKQIKL-------AATDGEKAAA----KTVKEELVHKYSYAIVDGH 496  Ectoc...
XP_004347638          243 QHRhelasplpkV----LEYDKCDFTKIAAHLMRLREKKRs------ALTAKE--------KAKKAERALKHGVVVVDGV 304  Capsa...
goetting:Ngar_c04450   72 EKFr--------N----ITIKDIDFSAAYRLADEEKRMKEqekerykTLAKEEKKKIslakKAERERLKATYGKAVVDGV 139  Candi...
BAJ47816               73 GRFq--------D----VTINEIDFSEVYEYVERERQLKA---------DKEYRKKIsaerKRLREELKARYGWAEMDGK 131  Candi...
ABK76827               72 IK---------------LLYKDLDFSEAYRLVDMEKDKKD-------MMTKEEKKEIaakrKEIREGLKAKYGIAVMDGK 129  Cenar...
jgi:Nmar_1322          72 SKFk--------K----ISYEDIDFSDAYKLVDKEKDLKE-------MMTKEEKKAIaakrKELREELKSKYGVAVMDGK 132  Nitro...

1OIS_A                139 REQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKDAPVPP----APEGHKWGEIRHDNTVQWLAMWRENIFN 214  baker...
Q4N5U3                464 REKVSSNKLEPPGLFKGRGLHPKQGLLKARMFPKDVILNLSKDAPVPKvsnfQREGHSWKDIYHDNSVTWLAYYKDSIND 543  Theil...
XP_001610263          245 REKVGSNRMEPPGLFKGRGLHPKQGLLKGRTFPHSVVLNLSKDAPVPKvsmfERQGHGWSDIFHDSSVTWLAYYRDTVND 324  Babes...
XP_002907155          269 LEKVGNFRIEPPGLFRGRGEHPKTGTLKERVMPEDVTVNVGISDRVPIc---NVPGHAWKQVIHRDTVSWLAYWNENVMG 345  Phyto...
CBJ32924              497 LEKVGNYNVEPPGLFRGRGEHPKTGKLKARVTASDIAINCAEGVCVPRc---NMPGYAWQSVQHNPSATWLSKW-DGLLA 572  Ectoc...
XP_004347638          305 PQKFGPYVMEPPSIFLGRGNSPLTGHIKPRLSPADVTLNLSEGAPVPPs---PVPGTNWKAIVSRPTALWSATWTCKISG 381  Capsa...
goetting:Ngar_c04450  140 EVDIANWLVEPPGLFMGRGQHPMRGRWKPRVRPQDVTLNLGENAPVPEg--------NWKEIVHDHSSTWLATWIENLTG 211  Candi...
BAJ47816              132 RFEIANWMVEPPGIFMGRGNHPLRGRWKPRVYEEDITLNLGEDAPVPPg--------NWGQIVHDHDSMWLARWDDKLTG 203  Candi...
ABK76827              130 EVEIASYMAEPPGIFIGRGKHPLRGKWKRRIGPQDVVLNMGTKAKAPPg--------KWKKIVHEKDGIWIAKWTDNLVK 201  Cenar...
jgi:Nmar_1322         133 EVEVGNYMAEPPGIFIGRGEHPLRGRWKPRVTAKDVTLNLGKEAKVPEg--------KWGKIIHDKDSMWLASWMDFLTQ 204  Nitro...

1OIS_A                215 SFKYVRL 221  baker's yeast
Q4N5U3                544 QFKYMYL 550  Theileria parva
XP_001610263          325 QTKYMYp 331  Babesia bovis T2Bo
XP_002907155          346 GIKYVFF 352  Phytophthora infestans T30-4
CBJ32924              573 GTKYMML 579  Ectocarpus siliculosus
XP_004347638          382 LTKAIvp 388  Capsaspora owczarzaki ATCC 30864
goetting:Ngar_c04450  212 KRKYVWL 218  Candidatus Nitrososphaera gargensis Ga9.2
BAJ47816              204 KEKYVWL 210  Candidatus Caldarchaeum subterraneum
ABK76827              202 KDKYVWL 208  Cenarchaeum symbiosum A
jgi:Nmar_1322         205 KRKYVWL 211  Nitrosopumilus maritimus SCM1
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