5MHJ


Conserved Protein Domain Family
Herpes_ICP4_N

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pfam03584: Herpes_ICP4_N 
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Herpesvirus ICP4-like protein N-terminal region
The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.
Statistics
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PSSM-Id: 367571
Aligned: 5 rows
Threshold Bit Score: 199.282
Threshold Setting Gi: 81987336
Created: 20-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MHJ_A   35 PPPPGRVLYGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLY--TPDAEAMGWLQN----P 108  Human alphaherpesvi...
P09310  474 PLPSNRVRFGPSGETREGHWEDEAVRAARARYEASTEPVPLYVPELGDPARQYRALINLIY--CPDRDPIAWLQN----P 547  Human herpesvirus 3...
P90493  378 PPPPGRVLYGGLGDSRPGLWGAPEAEEARARFEASGAPAPVWAPELGDAAQQYALITRLLY--TPDAEAMGWLQN----P 451  Human herpesvirus 2...
Q6UDF2  632 PPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFM-----LQPLSRVSHsyggS 705  Psittacid herpesvir...
Q9DGT6 1197 LPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFhkSMKVNPLNWMHH----G 1272 Marek's disease her...
P09310  474 PLPSNRVRFGPSGETREGHWEDEAVRAARARYEASTEPVPLYVPELGDPARQYRALINLIY--CPDRDPIAWLQN----P 547  Human herpesvirus 3...
P90493  378 PPPPGRVLYGGLGDSRPGLWGAPEAEEARARFEASGAPAPVWAPELGDAAQQYALITRLLY--TPDAEAMGWLQN----P 451  Human herpesvirus 2...
Q6UDF2  632 PPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFM-----LQPLSRVSHsyggS 705  Psittacid herpesvir...
Q9DGT6 1197 LPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFhkSMKVNPLNWMHH----G 1272 Marek's disease her...
5MHJ_A  109 RVVPGDVALDQAC-FRISGAARnSSSFITG------------SVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRA 175  Human alphaherpesvi...
P09310  548 KLTGVNSALNQFY-QKLLPPGR-AGTAVTG------------SVASPVPHVGEAMATGEALWALPHAAAAVAMSRRYDRA 613  Human herpesvirus 3...
P90493  452 RVAPGDVALDQAC-FRISGAARnSSSFISG------------SVARAVPHLGYAMAAGRFGWGLAHVAAAVAMSRRYDRA 518  Human herpesvirus 2...
Q6UDF2  706 RLNKTEKNLCKIClPPDGGDDRdGGGKSRGgrgggskdasrtAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDAS 785  Psittacid herpesvir...
Q9DGT6 1273 KLSPADAALNHIYvQKFQSSYDsPGAAVTG------------TVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKD 1340 Marek's disease her...
P09310  548 KLTGVNSALNQFY-QKLLPPGR-AGTAVTG------------SVASPVPHVGEAMATGEALWALPHAAAAVAMSRRYDRA 613  Human herpesvirus 3...
P90493  452 RVAPGDVALDQAC-FRISGAARnSSSFISG------------SVARAVPHLGYAMAAGRFGWGLAHVAAAVAMSRRYDRA 518  Human herpesvirus 2...
Q6UDF2  706 RLNKTEKNLCKIClPPDGGDDRdGGGKSRGgrgggskdasrtAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDAS 785  Psittacid herpesvir...
Q9DGT6 1273 KLSPADAALNHIYvQKFQSSYDsPGAAVTG------------TVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKD 1340 Marek's disease her...
5MHJ_A  176 QKGFLLTSLRRAYAPLLAREnA 197  Human alphaherpesvirus 1 strain 17
P09310  614 QKHFILQSLRRAFASMAYPE-A 634  Human herpesvirus 3 strain Dumas
P90493  519 QKGFLLTSLRRAYAPLLAREnA 540  Human herpesvirus 2 strain HG52
Q6UDF2  786 QKTYLLSCLRLAFAPLVFPGaS 807  Psittacid herpesvirus 1 Amazon parrot/1997
Q9DGT6 1341 QKTFLFRSLKKAYASMAFPDnS 1362 Marek's disease herpesvirus type 1 strain MD5
P09310  614 QKHFILQSLRRAFASMAYPE-A 634  Human herpesvirus 3 strain Dumas
P90493  519 QKGFLLTSLRRAYAPLLAREnA 540  Human herpesvirus 2 strain HG52
Q6UDF2  786 QKTYLLSCLRLAFAPLVFPGaS 807  Psittacid herpesvirus 1 Amazon parrot/1997
Q9DGT6 1341 QKTFLFRSLKKAYASMAFPDnS 1362 Marek's disease herpesvirus type 1 strain MD5
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