Conserved Protein Domain Family
Adeno_E1B_55K_N

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pfam04623: Adeno_E1B_55K_N 
Adenovirus E1B protein N-terminus
This family constitutes the amino termini of E1B 55 kDa (pfam01696). E1B 55K binds p53 the tumor suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein. The role of the N terminus in the function of E1B is not known.
Statistics
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PSSM-Id: 113396
View PSSM: pfam04623
Aligned: 5 rows
Threshold Bit Score: 51.1381
Threshold Setting Gi: 82013569
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81981402   1 MEPGHPTEQGLHPGLRSHAPVEGLdqaAGTENLELLASTAs---SSGSSSSTQTNIHVGGRNeAGHGREpEER 70
gi 82013569   1 MEREIPPELGLHAGLHVNAAVEGM---AEEEGLHLLAGAA----FDHAAAADVARGEGGGAE-PCGGGE-VNM 64
gi 119031     1 MDPPNSLQQGIRFGFHSSSFVENMegsQDEDNLRLLASAAsgssRDTETPTDHA---SGSAG-GAAGGQ-SES 68
gi 119030     1 MERRNPSERGVPAGFSGHASVESGcetQE-------SPATvvfrPPGDNTDGGAAAAAGGSQaAAAGAEpMEP 66
gi 119034     1 MERPNPSVGGIYSGLHDNGPVENPa--AEEEGLRLLAGAAsarsGSS------A---GGGGG-GGGGGE---P 58
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