Conserved Protein Domain Family
DNA_pol_phi

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pfam04931: DNA_pol_phi 
DNA polymerase phi
This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.
Statistics
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PSSM-Id: 461488
Aligned: 94 rows
Threshold Bit Score: 343.066
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD27482              46 YVLNRLIKGLASDRNSARLGFSLCLTEAINLALgmgdnapqgVQSINEFLDLLSKTLPIDSntvatenktalkkKKGRDE 125 
XP_011482211          91 YTFKRLVDGLGHTRETARPGFSLALGQVLVAFE---------EIPLQSILDRVKQKHSLQA-------------VKKKLA 148 
EDW30625             111 YVVKRLIRATGADNKETVAKVGSIIRLIIRNVP---------DVNELDLLDIVERELPVNGq------------PKKKEE 169 
WGS:AAQB:GK16442-PA  145 YTLKRLVRATGSDDMQSVSQSAANIHCILTSVP---------NIDIYDLLETMKRDLPVSSgig-------gkqKKGKTD 208 
XP_001966550         110 YVLKRLIRSTGADDIKSVAQAASYIHCILSSVP---------GIDALEVLATLKKDLAVGSq------------QKGKED 168 
Q9W5E4               115 YVLKRLIRSTGADDMKTVSLAASYIHCILNAVP---------AIDAFEVLETLKRDLAVGSq------------QRGKED 173  fruit fly
XP_002010684         147 YALKRLIRCTGADDMDTVATSAGYILNILSSVP---------GLNPIDLLALLKHELPCNGs------------PKGKEE 205 
WGS:AANI:GJ16694-PA  147 YALKRLVRCTGADDKEAVALNASYINSILRDVP---------GLDPIELISVLKRELHASSq------------QKGKEE 205 
XP_001992496         136 YALKRLVRCTGADDMDAVALNASYINGIVSQVS---------GLKPIELLDVLKRELKVNSq------------QKGKEE 194 
OWR55017              55 YTLKRLVRSLGANIAELRMGYFAALVTILTRFP---------EITVTQLLELIKKELHASG-------------SSKSEV 112 
CCD27482             126 RGILFGKLFALQALLNEPLFSTIFlsedkkkIDSSLFIRYVDELFTLGSKKNWIRESCFFTLYQTIEKLLPYA-DIEFYQ 204 
XP_011482211         149 KNAMFGNLFGVLALHQSGRLFKEP----------QVVLACVQLLQSLSPHKQHLKDLPTKTIMDILTEIPEEVfEEVLLS 218 
EDW30625             170 TLAAVGQVITASSILELSQKLSNE----------RELAPIYAKLIGYMKGREYLMCLSNNVIVESFATVPEKRfATDVWP 239 
WGS:AAQB:GK16442-PA  209 SLASVGQVITVYTIMQTPYF-KN--------AEPKLLTALYTILIGQLKGREYLASMSANILADSFTQLNASVfESHVWS 279 
XP_001966550         169 TLAAVGQLVTAFCIVQTPQFMEEP--------NPKLVASVYEILVSQLKGREYLVSMCSDILAGSFKKLPAEIfEEQVWP 240 
Q9W5E4               174 SLAAVGQLVTAFCILQTPQFAKAE---------PKLVTAVFQILAAQLKGREYLVSLCGDILAVSFKQLPAAIfEEYVWP 244  fruit fly
XP_002010684         206 SLAGIGQLITVLCLMQTEYFDQPS---------SDLIQVVYPILIPNLKGREYLTSMCADIMGSSFAAVDVSNfKTYVWK 276 
WGS:AANI:GJ16694-PA  206 TLAAVGQLITVLAIMQSQYFQQPT---------AELIAVVYPILIAQLKGREYLVSLCADIMADSFKQVSLASfQSHVWP 276 
XP_001992496         195 SLAGVGHLITSYAIIKSPYFEPPA---------PELVDAIYPILVAHLKGRDYLVAMSIDIMAESFKQVDADIfESHVWP 265 
OWR55017             113 GDVALGHILACGAVFRSGLMLK---------CTEEEQKEVLQLFETASSKKSYLSTVATLVFIDFINNLDEEQfATIVWP 183 
CCD27482             205 LVLTLLDKYELTLSKEGLAIYLLIIyrsankKQLEkTLSDIQLsnSHW-KSNNPLARGNLPALTNILRDSnvtefqdhek 283 
XP_011482211         219 ALKSDLA--SAFNTPEQLQLLLVAL------QRFP-QSLKPKKlkKLL-GSATIINADNVPRLIEVLKM----------- 277 
EDW30625             240 VLKQDISKPVSQLNLHTCDVLLAVH------DSYNnILTQDQLmaILW-----P-KKIEYSELFKIYFAA---------- 297 
WGS:AAQB:GK16442-PA  280 QLKSVILLPIAKQKIYLFDLLLAAY--------FQ-KILSRNQl-------ESALSLKNFEDVFELYLNS---------- 333 
XP_001966550         241 LLQSHLNKSLSALKVNTCDVLLSIH------LAYPaILGRKQLlsSLWtKK------PQYEQLFELYIAG---------- 298 
Q9W5E4               245 LLQPELNKPLSGLKVNTCDVLLAVH------LTFSsVLGRENIlaSLW-----P-KKPVYTQLFDLYFSG---------- 302  fruit fly
XP_002010684         277 ILQPEINKPLTAQKLHTLDLLITVH------NRYPtVLPLEQLqsILW-RN----QPPQYEELFNFYLK----------- 334 
WGS:AANI:GJ16694-PA  277 LLQPELNKPITAQKLHGCDLLLSVH------LNYPkLLPLRQLqtMLWrKQ------TQFEQLFDTYLNN---------- 334 
XP_001992496         266 LLQPKLSASIAKQTLHSCDLLLAVH------LNYSaVLTLKKLksILW-----QTQQSQYAQLFELYLNS---------- 324 
OWR55017             184 NIKQNYKKAINEHNLDSLYFLMIVN------EKFPkKVKLRKLi-----GVPELLHEDHISDICDKLMT----------- 241 
CCD27482             284 pptknnkqpPANWAPRLHFVWDILLPILttttteedtnsddkhiskkrkkikknQDSNEFIRFPEFWQMAIDESF---FN 360 
XP_011482211         278 ---------AAHSVKKELILPAVALDLL--------------------------KLSLKEDSFQLFWNKAVTEGM---FK 319 
EDW30625             298 ---------PKMYDPRIYARFGKFLGTA-----------------------------DKNSKILESWQNYA-------YE 332 
WGS:AAQB:GK16442-PA  334 ---------SISQNANAYKRFAKFLIQK------------------------------EQAKLLKQWQKYVDDKI---VT 371 
XP_001966550         299 ---------STIHSDGVYSRLARFIA-------------------------------SGGQELLSAWQQFVDAKQpikFN 338 
Q9W5E4               303 ---------STIHSDGVYARLASFLV-------------------------------NGGKDMLAAWQQYIDSKQplkLN 342  fruit fly
XP_002010684         335 ---------APTLLKYTTYILGKFLAKC-----------------------------SNEQALEA-WLKHVIEKL---PS 372 
WGS:AANI:GJ16694-PA  335 ---------ATMQGDGLYARLGKFLATC------------------------------SSEQVLAAWQQHIAEHLp--FK 373 
XP_001992496         325 ---------ASMQSDGVYERLGKFLASN----------------------------ANGGEQLLTAWQQHIVAQL---PV 364 
OWR55017             242 ---------GVDFNSLSHPIYQECGKQI-----------------------------ANSPHLSIFWNK-IDSHL---VK 279 
CCD27482             361 EKA-SSERKYLGFLIFQKTIQ---S--IGknNAKlISTCFTRNF-MRSLIN---QSSDNKR--------------LLHKM 416 
XP_011482211         320 E-P-SGPTHYLSFRLLGSALP---L--LS--LSQ-LKEVLSGEV-MMHYGE---HVVSAQKpd----------rfKLAPE 375 
EDW30625             333 HRSqNVASKGCIFKVTKHLII---S--QKnaNEQqLIDLFASPL-MDFILD---ELLAAKTtsaknq---kpltmQFREI 400 
WGS:AAQB:GK16442-PA  372 AN--NSRFKMCALQIITYVLLycnE--SS--DQRiIVELFSPNV-LEMLFN---ELQSAKRkrsekt---kashlELKAI 438 
XP_001966550         339 SAK-ACVIQVLGHIILNFAEE---D------EQP-ILDLFAPTT-IKFLLQ---ELSSVKGdkseak---kpsqkELREI 400 
Q9W5E4               343 AAK-ACAIQVLSHVLLNFKPR----------EEQlILDIFTPTC-VQFLLH---ECSSVKWdkgegk---kpslkKLKEI 404  fruit fly
XP_002010684         373 NNI-VEKSCFISTLTNIIVYM---DenKPesRVQ-LKSIFAAEPlVTMLVE---ELRAMKKydnkkk--ggdakdKMRFI 442 
WGS:AANI:GJ16694-PA  374 HVT---AKSYIIQTLSHVLMH---YddGSrtDMQ-LEQLFTLEPlVSMLLG---ELTAAKKlnskanakakaaqrQLRYI 443 
XP_001992496         365 KRI--GAKCYIVQTLTHILLHyddDdgGKrnDAQ-LEQLFGTEPlVSMLLQ---ELASAKQrpkkski-cksaelQLRGI 437 
OWR55017             280 H---NRNRELVSLNILNTVLL---N--LKdnVEV-IPDLLSDNF-FKLFMDwfkGLQTASKirnkrd--neddskIMVKK 347 
CCD27482             417 SQIAIDTIVKVCE---DDPSnKLIPCLDALlFNTnvgGSINFDKLTKSKT-VSKLIsiKHLSSSTLRQLIKLFISQINAm 492 
XP_011482211         376 MEKYVSDFLRDCQ----DSD-KQLAVVVAF-------SSLTNNGYPVVPS-VWKVV--QHLQPAALQSYVAWLRSMFLQp 440 
EDW30625             401 CQEFECAVILLFEnpaTGDE-TKARILSNL-LRK----RGNLNELATTRRfTETLL--NTLKYGGLKILFDLYASLLATp 472 
WGS:AAQB:GK16442-PA  439 FPQLEAILLLFYKskvSQDD-VKVQILMRL-LD----NAVRLESVIHLPKyIEQLI--NELSPDGVYKVYSYFRDLLFK- 509 
XP_001966550         401 VYKFEGSLLLAFEkqlKKEE-TKLQLFQKF-LEE----RLQVDLVINLPR-FSQQVi-GFLGVESLKTLYEFYQTKLTTl 472 
Q9W5E4               405 CFKFEGSLVLCYEkqfQNDD-NKLHLLLKL-LE----HTLQLDSVISLPRfCQKLI--NQLSVESLHKLYDYYNNKLYSl 476  fruit fly
XP_002010684         443 CRQFEAAIILCFDqifKQDD-SKLQILRPL-LEQ----QLNLDMIAQTPK-LTQTLf-TKLSAEGLDQMYDFYFENFTSn 514 
WGS:AANI:GJ16694-PA  444 CRKFETALLVSFQqqlKQDA-CKLGILRPM-LQL----QLQLDNIVQTPR-FTQQLl-AQLGEQGLEQMYEFYSEQFTSn 515 
XP_001992496         438 CHKFEKALLISFKhklKQQS-NKLHILRAL-LQQ----QLQLDNVTQTPR-FTQQLl-GQLDEAGRTMMYEFYREQLISq 509 
OWR55017             348 QKEVLMSLAKALQlpsVDSK-IRVKTLDKLlFSP---GEINFTEITGSTV-VKSIT--AGLDVDGLKKMAKSLKKVFLNs 420 
CCD27482             493 s---------------------tEKEITIVNQFALDTILHVVRSHKS--EFdyDSVVEpLLNPLVKLAFFSK-------- 541 
XP_011482211         441 qmtklldfstrkqkdkqqvqpemETPVSRLRKWLVARLCSIIDNHQVkkEE--ALIMD-VARFVFFHAFFSTkkvsqdik 517 
EDW30625             473 vgm-----------------eepQDNGPRNQLECVSQMQAILQHPELdaNKkeRWS---MLKTILTAGVCHVasgl---- 528 
WGS:AAQB:GK16442-PA  510 -----------------------ESVSKSCRIYCLGRLNAILARDGLt----dENRKTeMLQMLYMATFNVNyeqk---- 558 
XP_001966550         473 -----------------------GDEEKLNRSYCLNQMHFILQNAQLa-EKesKWRNK-QLRQLMLAGLFHLdgsl---e 524 
Q9W5E4               477 -----------------------EDEDRVSRVHCLNQMQLILNHSKLsqTA--KWRQK-QLNYLLLAGLFHLdask---k 527  fruit fly
XP_002010684         515 ----------------------nEKLTPSDREHCLKQMQNLMHSKRNq-----------qLRFLLNASVFHLddql---k 558 
WGS:AANI:GJ16694-PA  516 ----------------------nELLTRTNREHCLKQMQQLQNSRRN--KQ---------LEFLLFASLFHLndqq---k 559 
XP_001992496         510 ----------------------aENLGKSHREYCLNQMHQLQLEFSKrsDQ---------LDFLLHAAVFHLdaeqk--p 556 
OWR55017             421 skkvi-------------kegveRNWYNNERVKAAELISYMVSHEAVkdDA--EFKIK-YMQLLMCFGFFKIg------- 477 
CCD27482             542 ---DNE--ALNE----LAKERLYSI-LSELTGAts-----------sPKSSNAAHSWHYYTLQLILELEKSGN-Qe-LVN 598 
XP_011482211         518 etqETLsvSLDDktrgALVNSFFGL-LTSLHRVplceggnaasqkrvlGVTADGAMWIDHLAQYAHVLLNHPKhVq-TSQ 595 
EDW30625             529 qpcPPAasILSDstadRCKTIFIGL-LIRSCHG----------------DIKELSKDLRKTLEFLRKFLSKTEnAnaQRH 591 
WGS:AAQB:GK16442-PA  559 pcsQANacEFNElkgtHFRAMFYNNlLKEARSL-----------------EDLLPQLNFFTSRVIKEFANSENeTklRCG 621 
XP_001966550         525 pcaASEasAFSRqcsaRCEEIFLGS-LLHKCPG-----------------LPALCQLLQKNLGFLNKQLSKADaEtkLLN 586 
Q9W5E4               528 pceAAQasAFSRqcaaRCEEIFLGS-LLHKCSG-----------------LPGLCQLLQKTLSYLNKELGQPDaEskLRS 589  fruit fly
XP_002010684         559 kctAGDaaIFSRqaasRCEESLFNC-LVHKLGVn------------kEQLEDLNQVLRTLLLPFSRKLFKSSNeSk-LRI 624 
WGS:AANI:GJ16694-PA  560 pctADEaaVFSRqaasRCEETLFSClVNKIGTN--------------TEQLAALNEQLRPLLGQLAKKLSKPGiEgkLRI 625 
XP_001992496         557 cdgGQLaaQFSRqtasRCEEVLFSCvMHKLGSG--------------SEQLATLNGLLRGLLRQLAKHMSKPDfEskLRS 622 
OWR55017             478 ---GDEsvAVSSslagSIKACFYRC-FTSRFSN-----------------VEGLVTVLSSLSSFITSMMTKEKvRskLEK 536 
CCD27482             599 KLDADLETIKNNGLKVLNE--ISMTNTdemtQQSKGLELLLSMCILQLFSGD---TESLSTIEELVEFYsns-------- 665 
XP_011482211         596 PFTPEQRQAWDGMMESVTN--LKKKAKkgataESNAFQQLFLLLGMHLFKAP---EELQDTMKDLQTCVdkaqekkakkr 670 
EDW30625             592 APNADQQLAWN----VLEK--LQHSDDnesnASAQIIEVLILFVGLAQYTSCc--QLQIDILNDLMVCRnmkmkeq---- 659 
WGS:AAQB:GK16442-PA  622 PRSAEQKGTWKAIENIILE--AKKQKNt--dKLKQTLDGLILFVSLTQLSGD---PRLVTVLKDLIQCKvfatske---- 690 
XP_001966550         587 QRDEALQKLWPHVEKLLTK----PSEEs--dVVAQSFEALILFVALALCTKS---NLPVAVLDDLIICRknavdkk---- 653 
Q9W5E4               590 PRDESLQKAWKQVEKLLER----PSKEs--dVVGQSFEALILFVSLALCTKI---PPSITVLEDLIICRknalqks---- 656  fruit fly
XP_002010684         625 KLTPELRKTWEKVQTVVESdpIKETEIk---aYGLIFDTLIMFIGIATLMPNs--NMELDIIDDLLICKenaiksksq-- 697 
WGS:AANI:GJ16694-PA  626 TVTPEMRVMWEKVQKVLNA----PVKEk--qALAVIFDALILFLGLAMFTPSc--NVALDLIDDLFICKqnalktkqak- 696 
XP_001992496         623 KLVPDFQQVWPAISVVVNA----KAAAkdmttLALVFDALVLSLALAMFMPSc--SITPELVTDILICKqnaldpkpck- 695 
OWR55017             537 QFDKENMDCWEMLTKVCGK--IEKNQSk--sKVENVFLILLYQLGLFLFSEPthvKIASSSIIELKSCYehymkdrkak- 611 
CCD27482             666 -------kqeESTSLVGITEILLSLLAQKKAILRKLSLSVWEHFISDIGKNELNVLLAVLPVR-EN-KQGFAHLF----E 732 
XP_011482211         671 kkkqaaeqeeEPEWVEVMVDILLSLLSQPSRHIRLVCRTVFSSICPHLNLAALNAILDVLNPD-KN-SEENSAVV----V 744 
EDW30625             660 ----kmeseeDPSWQEVVTDILLQLLLETAGHWREFTNIIVKSMLPYLEQVHLTQILQRLDMD-SN-PLGEDEN-----E 728 
WGS:AAQB:GK16442-PA  691 ----kskktlDVSWKEVLTDSLLVLNLQNEQFWRKFINLVLASVIEHLEEQHLEQILAVLDMR-KN-PLSKNE------- 757 
XP_001966550         654 ---kkkaggeEPDWQDVLTDALLQLLLQTGHFWREFVNLVASALIPHLRTSNLEQILEVLNMN-KN-PLSKKN------A 722 
Q9W5E4               657 ----keqvneELKWQDVLTDALLQLLLQTGHFWREFVQLVATALIPHLEHGNLEQVLEVLNMN-KN-PLSKKS------- 723  fruit fly
XP_002010684         698 -anessasesEPSWQSVVTEALIQLLLQTGNYWRQLIKSVGATLIHHLSRDNLKQILGFLDIT-KNpLVGNSDIY----V 771 
WGS:AANI:GJ16694-PA  697 dkqrksaaeaEPNWQEVLTDVLLQLLLQTGHFWRLFVNAIGGALMPHLNKRNLEQFLELLDMD-RN-PLDDKDW------ 768 
XP_001992496         696 enknnslsesEPCWQEVLTDVLLQLLLQTGHFWRSFVNNIFGALMPHLGSDNLGQMLDNLDMT-QN-PLGIKDGEqddvE 773 
OWR55017             612 tskkensikdEPEWIEVVTEVLLSILSIESSVLRSVVQCVFRLLWEYLTPSSIAQIVSVLDPEsEAnPLGQESDLe---D 688 
CCD27482             733 GADEYEEDDDQEEGE----------GNEDEEENDdINSSNsesdsgsssdSDSDDNDNVIENGDIANIDkeatsa-laka 801 
XP_011482211         745 TDDGNQTKKRKLEDD----------EEEEEETED-EESDG----------SDDDSEEEESDDAEMLEDEqeeqmgeevvd 803 
EDW30625             729 SSSDENENENEGEGE----------SNDDDNDSS-ADDDD----------NSEDEDED---AATLEDNAl---------- 774 
WGS:AAQB:GK16442-PA  758 NEDEDADDDEEEDDE----------EDESEASSD-EDSSE----------DEDDENEKDDEETEKEENEveeddtenarl 816 
XP_001966550         723 DEEESDEEGEEEEEE----------EKDSSDDSD-EEDSE----------DDGDEEEDDDEDGGEDEEEsq--------l 773 
Q9W5E4               724 -DGEEESDDELDKEE----------SLKDSSDDS-EDEDE----------DEEEDEGEDDAESHLA-------------- 767  fruit fly
XP_002010684         772 NSDGDGDTSEDDEDD----------DDNDGADDD-DDDDD----------DDDDADDDKEAAMDIDEATnl--------- 821 
WGS:AANI:GJ16694-PA  769 ---DDDDDKSDEEDE----------EDEDDDDDE-DDDDD----------EDDEDEDEDEDDEATNLA------------ 812 
XP_001992496         774 DEDEDEEMETDEDEDnepasaekqdKDEKDEDEE-EDDDE----------DNDDEENEDADDADDDEYDdat------nl 836 
OWR55017             689 DEGEFDDSDEEGNEN----------CQENEENGEhNDSEE----------SESEMDDDDDDEKDLNTPD----------- 737 
CCD27482             802 lNLPENIVNEKGEVDlaklenmsdndldnSINDDDDDESD-------EEsMDDEKMMELDDQLSEIFKR-RKEAlsnist 873 
XP_011482211         804 qNFRLELMKVLQQQN--------------ALATEEDASSD-------ED-LDDEAMMKLDQSLSALFLE-QKKRiq---a 857 
EDW30625             775 eKLRDDVRQALQNGD---------------DGASEASSVDw------ND-VAEESGKRLDESLAAIFKM-RSQA------ 825 
WGS:AAQB:GK16442-PA  817 eELRESVRLALTKDM----------------ANNDDDDNDgassvdwND-VDEAEGERLNAALERSFQAfKPKTa----k 875 
XP_001966550         774 aQIRESVRQALVAEG---------------EAEDDASSVDw------ND-VDEEQGQRLNAALERSFQLfKPKSg----k 827 
Q9W5E4               768 -QIRESVRQALVNDG--------------DADDDGASSVDw------ND-VDEEQGERLNAALERSFQMfRPKSr----k 821  fruit fly
XP_002010684         822 eVVRENVRKALLDDA---------------NNDDDASSIDw------ND-VDEEQGERLNKALEAAFQVnKKGKgnsqqg 879 
WGS:AANI:GJ16694-PA  813 -RIREGVRQALLSNE---------------NDDFDSSSIDw------ND-VGEEEGERLNQALERAFHIrKPKGa----k 865 
XP_001992496         837 dQIRENVRLALLNDD--------------NDEDNDASSVDw------ND-VSEEQGDRLNRALETAFHAfKPKGq----s 891 
OWR55017             738 -QLRMAIQKALGNTT----------------VDTDVESID-------ADmITEEEGKKLDEALAEAFKQfHQGK------ 787 
CCD27482             874 GNQRKIEVKESR---ENVIAFKHRVIDMLMIYM 903 
XP_011482211         858 KKDEKAKLQKEK---SLVLDFKIKVLDLLEVFV 887 
EDW30625             826 SQRKKRPTKSDRihsTTLLHFRVRVLDLVEVFA 858 
WGS:AAQB:GK16442-PA  876 SEAKRRPTKSERinsTTLMHFRIRALDMLEVFV 908 
XP_001966550         828 SLAKQRPTKSERidnTSLLHFRIRALDLLDLFS 860 
Q9W5E4               822 AQEKERPTKSERidsTNLLHFRIRALDLLELFI 854  fruit fly
XP_002010684         880 KDSKKRPPKSVRiteTTLLHLRVRILDLVELFF 912 
WGS:AANI:GJ16694-PA  866 GKNAKRQTKSERitdTALLHLRIRVLDLVELFI 898 
XP_001992496         892 KSKSKRQTKSERinsTTLLHFRIRVLDLVEQFV 924 
OWR55017             788 -NKKTKKERKNK---KSLSDFRIKVLDLIDIYL 816 
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