Conserved Protein Domain Family
TIMELESS_C

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pfam05029: TIMELESS_C 
Timeless PAB domain
The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologs of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. This entry corresponds to the PAB (PARP-1-binding domain).
Statistics
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PSSM-Id: 461529
Aligned: 40 rows
Threshold Bit Score: 38.435
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CRK93394      912 LRDRLLKeNKG--NLILWLQRVLTECCyvklnllysnenisntstfstiMEpipRHCIlNkQSIPLVPFNSEQNKILVYQ 989 
CDW58277     1033 LVGSLMKsGFG--EAIDWLIQVITETIed-------------------nAA---QKTSeIgEAIPVVPIEEIHCKAVRRP 1088
RWS04784      934 LVTELIElGFR--QQLNWIKDLLLETCfvkilndk-------elnnysiPEpvvYYNNyIgQSIPIVPYNEKQEKALYNN 1004
XP_002432421  864 LNCDVNYdPIT--KPLEPIPHYYSHLN----------------------------------QSIPIVSWNAEQADVLLLQ 907 
ROT64156     1022 LIGQLKEeGYG--AQVQWLQLQLLEACysklkmv---------gpnlpkAEpvpCHFTlSnQSIPLVPWTSEQEEAFSSL 1090
XP_008482101  397 TIRNLMDaGLQ--AIVEWVKESLEETLa--------------------dID---DDET----DVPLVPIIPETQQGIEHE 447 
RZF48533       84 ALNNAVFdGFK--EPLEWLVSSMTEMLe--------------------dLE---DNQE----DVPLLPLTETCTQAMENG 134 
XP_016662949  983 AIKKVIDkDMK--TALLWLVESLDEAAn--------------------dLD---VDES----DIPLLPLTDECMTAVNDI 1033
CDY50493     1004 VSRKLKQlGLR--LPRGKKSEAGMKLQd-------------------------dHDDSsAdESDNETLLAFKKRKSMTRR 1056
CAP91753      881 EGEDIPD-GPLfpANPRSKSSALDDLK-----------------------K---KRKK-KqATTEREPLDDETLEARRDA 932 
CRK93394      990 PFVLLLHKL-GFHL---------PADAn--KLFVRIPEFWTSEILL 1023
CDW58277     1089 DFKRLLHEL-NFWA---------PDGIq--HKYWRIPDTFSVLQLQ 1122
RWS04784     1005 KFLQLLHKL-GFHL---------PTDVg--RIYPRIPSFFTPDLLF 1038
XP_002432421  908 PFQLLLHKL-GFHL---------PADTg--KVFARIPSFWTVDVLF 941 
ROT64156     1091 KFRQLLGEL-GFHL---------PSDTg--KIFPRIPHFWCPEVLF 1124
XP_008482101  448 DVVNMLRSL-GLKS---------PRENm--EIYWRIPGVWNTNALR 481 
RZF48533      135 SFTSMIEVL-GVKK---------P-DEq--EIFWRLPGNWSEAKIK 167 
XP_016662949 1034 DFQEMMQVL-GIHK---------PSSIq--ETYWRIPGRWQANDIR 1067
CDY50493     1057 KLEKHTRPSnEISP---------EGSEdktERNETSPDVIATSKEE 1093
CAP91753      933 RLSNALSRQaKIKSdlfihasdeESDEeadKEFFRLEEERRIQQAK 978 
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