2ZD2,2R6I


Conserved Protein Domain Family
ATP12

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pfam07542: ATP12 
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ATP12 chaperone protein
Mitochondrial F1-ATPase is an oligomeric enzyme composed of five distinct subunit polypeptides. The alpha and beta subunits make up the bulk of protein mass of F1. In Saccharomyces cerevisiae both subunits are synthesized as precursors with amino-terminal targeting signals that are removed upon translocation of the proteins to the matrix compartment. These proteins include examples from eukaryotes and bacteria and may have chaperone activity, being involved in F1 ATPase complex assembly.
Statistics
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PSSM-Id: 336733
View PSSM: pfam07542
Aligned: 246 rows
Threshold Bit Score: 97.5487
Threshold Setting Gi: 290990213
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZD2_A          7 RFWASVGIhke--eggWAVLLDERPLRTPGKQPLRLPTEA--LALAIAEEW----Q---------AVQEVi-DP---NAM 65
gi 74604304    51 RFWEELAVkdle-ngnITVTLGGKSLRTMGQHDLILPATKkpLAHLLMHEW----Qvl-----psLKL----KN---HSV 113
gi 359380824   71 KFWDKVDTeyvedknhYEIKLDSRTLRTPLGFPLAVPAEKkqLAYLIQHEW----S---------SLPELkiKL---NSM 134
gi 927380151   39 KFWEKVDLaek--ddgYHILLDGKSIKTPLGFQLTVPKNKhtLAYLLAHEWkhlpS---------LQi----KP---YLV 100
gi 1050827973  51 tFWEKVDVake--kdgFHVRLDGKSLKTPLGNQLVIPSAKksLAYMVCNEWk---N---------LSNLKv-KP---HSV 112
gi 150864752   28 KFWEKVDThydatkdlYEVQLDGKTLKTPLGFPLALPSSKkqLAYLIANEW----A---------NLPDLkiKT---NMM 91
gi 260947912   59 KFWDKVETsfnkktqsFETHLDGKALKTPLGNILSVPANKkqLAYLVSHEW----E---------NLIDLkiKP---NSL 122
gi 575521669   77 KFWDKVDTsynedikkYEIQLDGKTLKTPLGFPLALPEDKkyFAHLIQHEW----S---------NLPNLkiQT---NSM 140
gi 444323980   31 sLWKTVSVspidgtsqVALQLDGRTVRTPGGLPLEFPDTHtvLASMLQREW----QavtekatkgKGPGNw-KKlqrENL 105
gi 598062863   57 KFWKNADAkyntdtkkFDVQLDGKTLRTPLGFPLSLPESKkqLAELIAHEW----Anl-----pdLKI----KT---NSL 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZD2_A         66 PLTRSANSAIE-K------------V--A--------------PQFDAVAAMLGDYGGTDLLSY---R---A---DAPEA 107
gi 74604304   114 PLTSLVSRAIDiS------------KspA---------------VRDAAIKDIMPYIDTDALLI---Fep---sdSYQGR 160
gi 359380824  135 PLSSLACRSIDlH------------NtaNnegvdp--elitkvGKVDDIKLNLLRYFDTDTCLI---FttkD---EYEGK 194
gi 927380151  101 PLTSLVSRCIDlE------------QshNkqdae----lltkvGDKENLKALLLRYLDTDTLLV---F---SpakDCDGK 158
gi 1050827973 113 PLTSLSTRAIDlS------------IshAvqdle----altklGNLEDIKTDLLRYLDTDTVLI---F---SpkeDCDGK 170
gi 150864752   92 PLTSIAARSIDlI------------NihEkeagseknemiakvGDLDDIKFNMLRYLDTDTCLIfttR---D---EYRGT 153
gi 260947912  123 PLTSMVARATDlGivfgseevdkdlVtkV--------------GDLQDIKYNILRYLDTDTCLI---FttlD---EYEGR 182
gi 575521669  141 PLTSIAARSIDlQ------------AahEkfeedr--dlaakvGRLEDVKLNMLRYLDTDTCLI---FttlD---EYEGK 200
gi 444323980  106 PLTSLVGRCLGlQ------------MspK---------------DRNAAKKSLIPFIDTDTLVV---Msp---qnELDGV 152
gi 598062863  121 PLTSLASRAIDlT------------HihDqevadre-emiakvGNIEDIKINVLRYLDTDTCLI---Fat---hkEYSGK 181
                         170
                  ....*....|....*..
2ZD2_A        108 LVRAQAEGWDPLIDWAA 124
gi 74604304   161 LRAAQENDFRPVIADAE 177
gi 359380824  195 LRARQDELYLPLIAEFE 211
gi 927380151  159 LREAQEQTYRPIIKSME 175
gi 1050827973 171 LRRAQEEMYRPLIASME 187
gi 150864752  154 LRKRQDELYLPLIAEFE 170
gi 260947912  183 LRNKQEELYRPLIEEFE 199
gi 575521669  201 LRAKQDELYLPLIEehe 217
gi 444323980  153 LRSRQEELYPKFVKLTE 169
gi 598062863  182 LRKKQDELYLPLIQEYN 198
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