Conserved Protein Domain Family
SMC_Nse1

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pfam07574: SMC_Nse1 
Nse1 non-SMC component of SMC5-6 complex
S. cerevisiae Nse1 forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism. It is conserved in eukaryotes from yeast to human. This domain lies immediatley up-stream of the DNA-binding zinc-finger domain, zf-RING-like pfam08746.
Statistics
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PSSM-Id: 311503
View PSSM: pfam07574
Aligned: 89 rows
Threshold Bit Score: 145.393
Threshold Setting Gi: 159489866
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74605913    28 RYLLQFILqCKGIVSENSLLSCYLTLENDAgrflkdeplsltawrLKLTDHVSKLNLQLSPLNYRITMVNHPMGksyvsr 107
gi 552828313   36 HCFLQAIM-GRQYLKESDAKELYRQITGAAh-------------dGNYLHFMADINQQLNFAQFELRRVKYP-Gd----- 95
gi 357161140    9 HTLLQALL-SRGPLPEPDFHALFTDMtggkn---------pathkQLFVDTLGKINNELKYLNFDLRAGINQYD------ 72
gi 226529901    9 HTLLQSLL-HRGPLSERDFHAIFAGVsgknp----------athqQLFNDTLLKINKDLAYLQFELRACINQYD------ 71
gi 695045343    8 HVLIQALL-SRGPMTEEDFHAVFAGVsgkdp----------vthrQLFNEVLLKINKELAYVQFELRACQNQYD------ 70
gi 566167617    9 HTLIQALM-SRGPLTEDELFNIFADVtgknp----------rgnkRELNDYLLKINKELSYVQMEMRCCRNQND------ 71
gi 1000960003   9 HTLIQSLM-SRGPLKEDDFHKIFSSVtgknp----------rtcgREFNDFLLKINKELSYVQMELRRCRNQND------ 71
gi 359479187    9 HALIQALL-SRGPLIEDDFHAIFSGVtgknp----------gahqQQFNDYLLKINKELSYVHLELRGCRNQYD------ 71
gi 565375322    9 HTLIQALL-SRGPLKEKDFQSIFTKItgksp----------gnhqSLFNEYLRKINGELAFVQLELRACRNQYD------ 71
gi 571564629   10 HVVIQSLL-SRGPLSEKDLHAMFQDLtkrnp----------gterQLFDSFILKINKALSCANFELRACIDQYD------ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74605913   108 rfenfitdlvdanwppNARFYVYTNLKYDSQMKMATSFSAAD--------IGFLKWSIekiltesSYvQQF--EREEESS 177
gi 552828313   96 ----------------GEWYLGFVNREGDEPSKRATKYRGAKdgkpdtriTAYFRALLdqm-vasSA-ADQglGYLTSQQ 157
gi 357161140   73 ----------------GTVYYGVINTIADEESKLGSKYSVPQ--------IAFYKGLLeaivqeaGn-----dGTITTID 123
gi 226529901   72 ----------------GMVYYGVVNNIADEESKLGTKYSVPQ--------IAFYKGLLeaivqeaGn-----dGSITSID 122
gi 695045343   71 ----------------GKVHYGMVNNVADEQSKLGTKYSVPQ--------IAFYKGVVeaivqdvAt-----qGCISSID 121
gi 566167617   72 ----------------GGVCYGLVNTVPDEQSKLGTKYSVPQ--------IALFKGVIeaivqdvTa-----qGSISNID 122
gi 1000960003  72 ----------------GQLFYGLVNNVSDDQSKLGSKYSVPQ--------ITLFKAAIeaivqdaTa-----qGSISWSG 122
gi 359479187   72 ----------------GKVYYGVVNNVSDEQSKLGTKYTVPQ--------LAFYKGIIeaivqdvTa-----qGSISDID 122
gi 565375322   72 ----------------GHVHYGVVNNVSDESSKLGTKYSVPQ--------IAFYKGIIeaivqdaAa-----qGFISTID 122
gi 571564629   73 ----------------GQVYYGVVNTVSDEHSKLGTKYTVPQ--------IAFYKAIIeaivqdaSa-----nAAIFSIH 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74605913   178 DviDEVDNIlrekygdehyaGLKHFVsYRIGSGELMQTNE-----------ITQTRAEELLFELSERKWLYR--SPEGKI 244
gi 552828313  158 A--LYIQISpda------atQAEEEE-AAAVRQQADEVRK-----------LSMKERETVLAQLATDGWLAHmpSRAGCY 217
gi 357161140  124 AfnVRIDNQvi--------------------iaDSTQ--DsqsrlpssitnFSFNQKEKTLDDLIQDRWLSY--TSPGNI 179
gi 226529901  123 AlnVRLDNQva--------------------vlDGSQ--DsqsrlpssiknFSMSQKEKTLDELIRDRWLSY--TATGKI 178
gi 695045343  122 AlhIQLENQv--------------------qNCQSSQ--DtqsripaafksFTMSQKEKTLNDLIKDQWLCY--TSDGRI 177
gi 566167617  123 AlnIRLENQvq--------------------ngTGSEYQEgpsqippalrnFSMSQKEKTLDELVRDNWLCH--TPDGAI 180
gi 1000960003 123 AlnIRLENQvy--------------------nsAESQSQGsssqvppalrnFSLSQKEKTLDELVCDKWLCR--TPDGGI 180
gi 359479187  123 AlnIRLENQvl---------------------tgTSHSQGippnvpaafknFSISQKEKTLDELVQDQWLSS--TPDGKI 179
gi 565375322  123 AlnIRLENQfl--------------------agTESQTQGgsthipaafrnFSMSQKERTLEELARDHWLSL--T-DGKV 179
gi 571564629  124 AlnLSLDSQvt--------------------ivTDSQSQGsqpnvptalknFSLSQKEKTLHELVRDQWLDL--TTDGVI 181

                  ....*....
gi 74605913   245 GLDVRFLIE 253
gi 552828313  218 TLGPRSFLE 226
gi 357161140  180 GLGIRSFLD 188
gi 226529901  179 GLGTRSFLD 187
gi 695045343  178 GLGLRSFFD 186
gi 566167617  181 GLGARSYLD 189
gi 1000960003 181 GLGVRSYLD 189
gi 359479187  180 RLGVRSFLD 188
gi 565375322  180 GLGVRSFLD 188
gi 571564629  182 RLGLKSFLD 190
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