Conserved Protein Domain Family
Peptidase_M26_C

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pfam07580: Peptidase_M26_C 
M26 IgA1-specific Metallo-endopeptidase C-terminal region
These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated with pfam00746, they may be attached to the cell wall.
Statistics
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PSSM-Id: 336747
View PSSM: pfam07580
Aligned: 5 rows
Threshold Bit Score: 998.586
Threshold Setting Gi: 81667566
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1203 NLAEYNLGNTG-LLYTPNQFLYDrdsIVKEVLPELQKLDYQS--DAIRKTLG----IspevK---LTELYLEDQFSKTKQ 1272
gi 81667566   130 NISDATISDQQ-PVQTEKKVDAD---LVKSVTDSLKQVKYDAfdGDPKQVLRnwnhI----Q---LTSSSLVDSFNEVYN 198
gi 62512118  1136 QVKEYNVDDLG-VVYTPNMVDKNrdsLITKVKEKLSSVALDS--AEVKSITN---------N---PASLYLEESFAEVRE 1200
gi 530819121 1273 QVKEYSVAELGeVVYTPNMVDKDrsdLISAIVEKLSPVELQS--DPIYTHLG----RtgpnKvnaIKNLYLEESFQEVKD 1346
gi 764854731 1246 HVVEYTISGTD-LIYTPESFLNDrsaLVNDLVSSLSSVVLDS--DAMKAVINypttLnadtQtgtAKDFYFGESYDQVMT 1322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1273 NLGDSLKKLLSADAG-LASDNSvtrgylvdKIKNNKEALLLGLTYLERWYNFNYGQVNVKDLVMYHPDFFGKgNTSPLDT 1351
gi 81667566   199 QLPTLVPQLLEHTDN-IDTANQ--------RVSDNAGAIMVGMSYINRWYNVSYGDKQLLPVMMFDPKAFGS-NLDSIDW 268
gi 62512118  1201 TLDKLVKSLLENEDHqLNSDEVaeka-llkKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLMMFKPDFYGK-TPSILDF 1278
gi 530819121 1347 NLTHFVKQLVENQDHqLNTDEAakra-likKIDDNKAAVLLGLSYLNRYYGVKFDDVHLKQLMLFKPDFYGK-NVDVLDR 1424
gi 764854731 1323 NLESNVRKILVAS---LNGQGQasedyikeKIINNKAAFVLGLTYLNRWYDINFGEMNTKDLTIFEPDFFGNdAASALDM 1399
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1352 LIELGKSGFNNLLAKNNVDTYGISLAS-QHGATDLFSTLEHYRKVFLPNTSNNDWFKSETK--AYIVEEKStieevktkQ 1428
gi 81667566   269 LSKIGDWSTDELAPSNTVTAFNNKLAPlLNTQSDLVTFLGDLRKKWTPDLSDEEWFRSNTG--VHIVEIPS--------K 338
gi 62512118  1279 LIRIG-SAEKNLKGDRSLEAYREVIGG-TIGKGELNGLLGYNMRLFTKYTDLNDWFIHAAKn-VYVSEPETttedfkdkR 1355
gi 530819121 1425 LIEIG-SKEDYIKGTRTHDAFREVVAK-STLSGNLNDFLKYNMELFTSDTDLNDWFIKATKdnVYIVEPKTttpefadkK 1502
gi 764854731 1400 ILAIGNGGYDVLRAHNNVTTFASIIGK-QNNQTKLFDMLEDYRQLFLPEMTNNEWFKQTTK--AYVVEGKSlipevaakQ 1476
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1429 GLAGt--kYSIGVYDRITSaT-----WKYRNMVLPLLTLPERSVFVISTMSSLGFGAYDRYRs----sDHKAGKALNDFV 1497
gi 81667566   339 EAPD----LNLNIYHRLST-N-----KDLQEYILPLLNVKNDDMYVVSALGMMIFGSYEPYIdvkyhkDPVVYQEKVQAV 408
gi 62512118  1356 HR----------IYDGLNNd-------VHGRMILPLLNLKKAHIFVISTYNTIAFSSFEKYG--------KNTEEERNAY 1410
gi 530819121 1503 HR----------AYEGLNNd-------VHGKMILPLLNLKDAHMFLISTYNTMAYSSFEKYG--------KNTEAERTAF 1557
gi 764854731 1477 ETTDtyskYNVGAYSKIVNdTvsnptWKYNHMLLPLLTLPQENIFIITNMNTIAIGSYEHYV------DDYSTVENRDKV 1550
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1498 EENARETAKRQRDHYDYWYRILDEQSREKLYRT-----ILLYDAY-KFGDDTTSGK----ATAEAKFDSSNPAMKNFFGP 1567
gi 81667566   409 HKELTRLSTAWRDHFDFWYRMANEAGKKRLSNAn----IQIWDSY-NAIDSSKKGG----RRWLNKRDTDIPAVAEFFGP 479
gi 62512118  1411 KAEIDRVAKAQQRYLDFWSRLALPKVRNQLLKSqnsvpTPVWDNQ------VYVGLgganRMGYGDGGRVVTPVRELFGP 1484
gi 530819121 1558 KAEIDKVAKGQQNYLDFWSRLATDKVRNQLLKSnnmvpTPVLDNQ-NYKGISTD------RYGHTDSGKDVAPIRELYGP 1630
gi 764854731 1551 RQMVDLAAERQRDNADFWYKILDETNRDKLFRS-----VLNNEGYvMYGKDGTKSY----RNLTADVD----AIQDFYGP 1617
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1568 VGNKVVHNQ--HGAYATG---------D---------GVYYMSYRMLDKDGAI-TYTHEMTHDSDQDIYLGGYGRRNGLG 1626
gi 81667566   480 LGKMYEAAG--LSADAVG---------N---------AVRYYVAQVVNNFGGIgILSHEMTHNFDNSIYLDGFQHRPGTG 539
gi 62512118  1485 TDRWHQIN---WNMGAMA---------KiyerpwkddQVYFMVTNMMEPFGIS-AFTHETTHVNDRMAYYGGDWHREGTD 1551
gi 530819121 1631 TDRYHATD---WRMGAVAriygnpykdD---------SVFFMVTDMISDFGVS-AFTHETTHVNDRMVYLGGWRHREGTD 1697
gi 764854731 1618 INKWYREHPsiKTAFADG---------S---------ETYYITYDMLTDYGTA-LYTHEMVHNQDGDIYLKGYGRRIGQG 1678
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1627 PEFFAKGLLQAPDQPS----DATITINSILKHSKSDStegsRLQVLDPtERFQNAADLQNYVHNMFDLIYMMEYLEGQSI 1702
gi 81667566   540 VETYATGLLESPWDRT----FANYGLNTALTFYADNN----RTTNKSP-SRFQTRKDLQDYMHGVFDVTYLLDYAEAQAM 610
gi 62512118  1552 LEAFAQGMLQTPDKSTtngeYGALGINMAYERKNDGE----QLYNYDP-EKLDSREKIDSYMKNYNESMMMLDYLEASAV 1626
gi 530819121 1698 IEAFAQGMLQTPSVSNpngeYKALGLNMAYERPNDGN----QWYNTNP-NNLQSRDEIDRYMKGYNDTLMLLDYLEGEAV 1772
gi 764854731 1679 MEVYAQGLLQNVFNVT----EMNLGFNAVYN-SDDAN----RVHVGDPvARFNSEADFNEYYHNQFDVLYLLDYLEGTNI 1749
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1703 VNKLSVYqKMAALRKIENkyvkd---padgNEVYATNVVKELTEAE-ARNLNSFESLIDHNILSAREY------QSGDYE 1772
gi 81667566   611 VGKSAKD-KQLMYSQISY------------DPAKKADVVSGPISTEiADKLMTIDDFIDNNIIASRGY------QAGSYG 671
gi 62512118  1627 IRQNLSD-NSKWFKKMDKewrtnadrnrliGEPHQWDKLRDLTEEEkKLPIDSIDKLVENNFVTLHGMpkngryRTEGFD 1705
gi 530819121 1773 LDKHSKDlNNAWFKKVDKqyrga-------ntknQFDKVRPLNDEEkAIALNTVDELITNNFMTNRGPgng-vyNPSDFG 1844
gi 764854731 1750 L-AQSDAnKKAWLRKIENyyvq-----nngVDTHAGNSARALTDAEvA-SLKSFNDLIDQSIIVQRQYvnnptnTSKKWD 1822
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1773 RNGYYTIKLFAPIYSALSSEKGTPGDLMGRRIAYELLAAKGFKDGMVPYISNQYEEDAKQQgqtin--lygkeRGLVTDE 1850
gi 81667566   672 TNSYQTISMYAPDYAAVQSSTSVSGGITFKKTAFELLAAKGWSNGFISYITNKYAKDAKND------------KKSLSDT 739
gi 62512118  1706 -SSYQPVNMMAGVFGG-NTSKSTVGSISFKHNAFRMWGYYGYENGFIPYVSNKLKGAANKEn-----------KGLLGDD 1772
gi 530819121 1845 -SAYVTVPMMTGIYGG-NTSEGAPGAMSFKHNTFRIWGYYGYEKGFLGYASNKYKQESKQAg-----------LATLGDD 1911
gi 764854731 1823 RNSYVSVPMFAANFSALSNSNGSPGDIMFRRMAFELIAAKGYTDGFVPYASGQLSDLAMEKgsiiydtwnkknTGLITDD 1902
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511886  1851 LVLKKVFDGKYKT-WAEFKTAMYQERVDQ--FGNLKQVTFKDP------TKpwpsygTKTINNVDELQALMDQAVLKDAE 1921
gi 81667566   740 YALAKIFNGEYDNdYAIFKKAMFKERIDK--RQDFKPITITLD------KK------SIQLNSWDDLQNLMQTTVDQELA 805
gi 62512118  1773 FIIKKVSKNQFQN-LEEWKKHWYHEVYDKa-QKGFVEIEVD----------------GVKISTYAQLQSLFEEAVSKDLA 1834
gi 530819121 1912 FVIQKISDGRFST-LEDWKKAYFNEVVTSa-KNGIQAIDID----------------GKTYNSYEDLKRAFAEAVDKDKG 1973
gi 764854731 1903 HVLEYVFQGQYTS-WAEFKKAMFTERLEKaaTGQLKPFTMQYElgvadsTK------EVTITSFEQLQNLMKEAMEADIQ 1975
                         810       820       830
                  ....*....|....*....|....*....|....*...
gi 62511886  1922 GPRWSNYDpeidSAVHKLKRAIFKAYLDQTNDFRSSIF 1959
gi 81667566   806 VRAQGKKS----SLINDLKAAILTAELKQTDDFRSSIF 839
gi 62512118  1835 GMDDKNIKnh-yQYTENLKWKIYKQLLKNTDGFSSDLF 1871
gi 530819121 1974 TLSNGSVKf---DNTVALKEKIFKKLLQQTDSFKTSIF 2008
gi 764854731 1976 ANSL-NLNn---SRVHALKVKVYQALMNSTNDFRTSIF 2009
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