4PB1


Conserved Protein Domain Family
Nucleos_tra2_C

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pfam07662: Nucleos_tra2_C 
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Na+ dependent nucleoside transporter C-terminus
This family consists of nucleoside transport proteins. Rat Slc28a2 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Rat Slc28a1 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.
Statistics
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PSSM-Id: 336761
View PSSM: pfam07662
Aligned: 394 rows
Threshold Bit Score: 122.888
Threshold Setting Gi: 187903103
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PB1_A        208 LVAASFMAAPGGLLFAKLMMPET-------------------------------EkpqdneditldggddkpAN------ 250
gi 81598051   197 VCTAIVLNMLSTFFVLHIINPYDkdpslnydt--------------lhadyetgR-----------------QS------ 239
gi 81666907   203 VIAALLLNMFSTIIILSLINPYTinpeqdly----------------ipyfitkN-----------------NN------ 243
gi 122540268  193 VVTAVMLNIFSALIIASVINPYKsddtdvei---------------dnltksteT-----------------KTlngktg 240
gi 123564782  194 VVVAVFLNIFSALIISCIVNPYEpevedqkt---------------ieahlsteK-----------------EP------ 235
gi 122276955  194 VVVAVFLNILSALIISSIVNPYIpekedklv----------------------------------eiskgnaEP------ 233
gi 332371269  139 VVPAVFLNIFSALMVSCIINPYNasnydtmp---------------mskneeknH-----------------ES------ 180
gi 503889924  194 VVTAVFLNILSALIVSCIINPYDvapeeelsm-------------ntneslnvsK-----------------EP------ 237
gi 503539194  194 VVVAVFLNILSALIVSCIINPYDidandtlv----------------------------------eiqeektGS------ 233
gi 1032718738 194 VVVGVLMQLLSALAVSVIVNPYNdkeeiakgtqayqeregiegdqaeeaqgekeK-----------------EP------ 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PB1_A        251 ------VIDAAAGGASAGLQLALNVGAMLIAFIGLIALINGMLGGIggwfgmpELKLEMLLGWLFAPLAFLIGVPwNEAT 324
gi 81598051   240 ------FFEMLSEYLLDGFKIAVIVCAMLVGFIALLNLVDGIFQEIl------GITFRQILGYIFYPIAWVLNIHgNEIF 307
gi 81666907   244 ------FFTIIGEYILIGFNIATTVAAMLIGFIALITATNTIFKIIf------GISLQHILSYIFLPFTWTIGIPiAEIL 311
gi 122540268  241 kpkkvaFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSV-------GLNFKQLIGYVFAPIAFLMGIPwSEAV 313
gi 123564782  236 ------FFQVLGNYIVDGFQLALTVAAMLIGFVSLVTFLNNTFGFFf------NVTFTDIIGWVFAPVAFVIGVPaDDIV 303
gi 122276955  234 ------FFQVLGNYIVDGFQLAITVAAMLIGFVALVTFLNNSFLAVi------NISFTSLIGYIFAPIAFLMGVPtSDIL 301
gi 332371269  181 ------FFQVLGDYILDGFKLAVTVAAMLIGFVALVNFLNSIFVAIf------NISFTTILGYIFSPIAFLMGVPtKDSI 248
gi 503889924  238 ------FFQVLGNYIQDGFKLATTVAAMLIGFVALVTFLNSTFVAIf------NVEFTTVLGYIFSPIAFLMGVPsEDIT 305
gi 503539194  234 ------FFQILGNYITDGFKLAITVGAMLIGFIALVTFLNNSFLAIi------HVSFTTILGYIFSPIAWIMGVPaHDII 301
gi 1032718738 251 ------FFSMLSDYMVTGWNTAVIVAVMLIGFVALISMLNSLFEGLi------NISFTELVGYVFSPFAFLMGVPkEDMV 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PB1_A        325 VAGEFIGLKTVANEFVAYSQFAPYltEaapvvLSEKTKAIISFALCGFANLSSIAILLGGLGSLaPKRRGDIARMGVKAV 404
gi 81598051   308 LSSQIMGTKIVTNEFVAMQELAKNsqQ-----LSEHTKAVVSVFLVSFANFSSIGIIVGAVQALnKEASIKVARFSLKIL 382
gi 81666907   312 PVSKIMATKLITNEFVAMIDLQKIlhT-----LSTRSIGILSIFLVSFSNFTSIGIIIGTITKLnTTQGKIIAHYGLRLI 386
gi 122540268  314 PAGSLMATKLITNEFVAMLDFKNVlgD-----VSARTQGIISVYLVSFANFGTVGIIVGSIKGIsDKQGEKVASFAMRLL 388
gi 123564782  304 KVGSLMATKLITNEFVAMGNLSQIahS-----LSPKATAIISTYLVSFANFGTIGIISGSIKAIdKKQGAVVAKFTMKLL 378
gi 122276955  302 KVGSLMATKLITNEFVAMGTLHGIagT-----LSTKANAIISAYLVSFANFGTIGIITGSIKSIsAKQGSYVAKFSIRLL 376
gi 332371269  249 KVGSLMATKLLTNEFVAMSSLHNMssT-----LSLKANAIISAYLVSFANFSVVGIITGSIKSIsSKQGITVANFSMKLL 323
gi 503889924  306 QIGSLMATKILTNEFVALGELNQVaeA-----LSPKGNAIISSYLISFANFSVVGIITGSIKSIsEKQGGFVAKFSMKLL 380
gi 503539194  302 KVGSLMATKLLTNEFVAMGDLHNLt-G-----LSTKSHAIISAYLVSFANFGTIGIITGSIKSIsEKQGSYVAKFSMKLL 375
gi 1032718738 319 QAGSVMAQKVLANEVVAMTSLSALe-G-----LSEKTAAIMGTYCMSFANFGTLGMVIGGVKAIdAHQGNVVAKYSLKIV 392
                         250
                  ....*....|....*..
4PB1_A        405 IAGTLSNLMAATIAGFF 421
gi 81598051   383 YGAVLVSILSACVVGFI 399
gi 81666907   387 YSSTLVNLLSATIASLI 403
gi 122540268  389 LGSTLASIISGSIIGLV 405
gi 123564782  379 LGATMASMLTGTIVGMY 395
gi 122276955  377 AGATLASILTGTIVGFY 393
gi 332371269  324 LGATLASILTGTIVGLY 340
gi 503889924  381 LGATLASILTGTIVGVY 397
gi 503539194  376 LGATLASVLTGTIVGFY 392
gi 1032718738 393 LVSTLASMVTATIVGFL 409
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