4FXG,4ACQ


Conserved Protein Domain Family
A2M_comp

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pfam07678: A2M_comp 
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A-macroglobulin complement component
This family includes the complement components region of the alpha-2-macroglobulin family.
Statistics
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PSSM-Id: 311554
View PSSM: pfam07678
Aligned: 26 rows
Threshold Bit Score: 268.749
Threshold Setting Gi: 121995637
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FXG_E        372 KGY--MRIQQFR-K-ADG---SYAAW------LSR---DSSTWLTAFVLKVLS------------LAQEQ-VGGSPEKLQ 422
gi 121995637 1034 EGY--QNMLHYR-H-DDG---SFSSFgpgkwrEEDperNGSTWLTSYVLRSFS------------KIKDI-IDLDEKSLE 1093
gi 74948182  1226 IGY--QRQLSFM-R-PDG---SFSLFr-----SDWnnsDSSVWLTSYCLRVFQeas-------fyEWENF-IWIDATIIE 1285
gi 122067379 1249 IGY--QKQLSYL-N-DDG---SFSLFr-----ADWnqsASSVWLTAYCARIFSeas-------fyEYENF-IYIDPLVIQ 1308
gi 341940526 1047 KGY--MRIQQFR-K-NDG---SFGAW------LHR---DSSTWLTAFVLKILS------------LAQEQ-VGNSPEKLQ 1097
gi 157278135 1040 QGYlrIRILTFK-NkATG---AYGAW------SSV---PYSTWVTALVVKMLSlvterqstavgpSSQRL-KVVPQDEIS 1105
gi 768922204 1037 KGY--IHILGKKdK-TSG---AYGTF------PDS---PYSNWMTALMVKVLSmiaerqgeaiglQGRKT-RFVPLEEIR 1100
gi 74096023  1053 aAF--QREMTYR-T-THTnprVWSVF------THY---LPSTWLNAFVDKVFY------------HGRRYdTDMNVGPIC 1107
gi 47209714  1107 irqglVSVSSFR-R-GDS---SFSMW------VNK---GPSTWLTALVVKILA------------QVDPV-VPVDRQALS 1159
gi 48675959  1051 eGV--VSVMSFR-N-ADH---SYSMW------KSG---SASTWLTAFALRVLG------------QASKY-IDQDLNSIC 1101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FXG_E        423 ETSNWLLSQ-QQADGSFQDPCPVLDRSMQGGLvg------nDETVALTAFVTIALHHGLavfqdegaeplKQRVEA---S 492
gi 121995637 1094 SGYEFLLSR-QVENGSFTDAGEYFYGSQRS-------------SLTLTANALLALLEQ------------DKKNQT---A 1144
gi 74948182  1286 KNMRWLLQH-QTPQGSFFEVTWLPDRKMNRTNf--------DKNITLTSHVLITLATVKdis-----gtlGSRVAL---A 1348
gi 122067379 1309 KNIHYILQH-QKDDGSFWEVTWLPDRKVNQSSehprneivrSKNITLTAHVLITLVSVKdls-----grlGSSVAL---A 1379
gi 341940526 1098 ETASWLLAQ-QLGDGSFHDPCPVIHRAMQGGLvg------sDETVALTAFVVIALHHGLdvfqdddakqlKNRVEA---S 1167
gi 157278135 1106 QSVKFLLSS-QKTDGTFGDPHPMIHRDTMTGT---------NKDVAMTAFITLALNRSLpflp----delQTNVKT---S 1168
gi 768922204 1101 HSVRYLLSV-QKAFGSFGDPHPVKNIGVLHGE---------NGKASMTAFIALALHRSRqfls----tedKDKVDV---S 1163
gi 74096023  1108 NSLNFLIGE-QMAGEHFRERRPPLHREMHGAV---------KGPMTLTAHVAISMGEINsicl----pelNQRVIA---S 1170
gi 47209714  1160 ESVAWLIRKsQQPDGSFEEPSSYRPNRIVaag-------avDRSVFITSFVLIALQRATsin------epILQLRFhadS 1226
gi 48675959  1102 NSILWLVEKcQLGNGSFKENSEYQPIKLQGTLpie----aqENTLYLTAFAVIGIRKAFdl-------cpLMKISM---A 1167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FXG_E        493 ISKANSFLgEKA---SAGLLGAHAAAITAYALSLTkaPVD-LLGVAHNNLMAMAQETGDN---LY-WGSVTGSQSNAVSP 564
gi 121995637 1145 IDKAVAYL-SAH---TEESEELLPKSIAVYALQKS--KAP-DAAKHVASLKALAQQEDDR---TW-WTEDTEKLRASKGC 1213
gi 74948182  1349 TQRALAYI-ERNmdfLRHQAQPFDVAITAYALQLC--NSP-IAEEVFAILRRQARTIGDF---MY-WGNQEIPQPPRKLE 1420
gi 122067379 1380 EQRASRYI-ERNiglIKDYGSPYEIAVVSYALAQA--KAP-QAEHAFKILASKMRSIADL---NY-WGNDEVPQPPSKLE 1451
gi 341940526 1168 ITKANSFLgQKA---SAGLLGAHAAAITAYALTLTkaSED-LRNVAHNSLMAMAEETGEH---LY-WGLVLGSQDKVVLR 1239
gi 157278135 1169 ISKAIEYL-QLQ---LENITHPYAMAITSYCLSTCp-SEErNRTAAWKKLQLMVKEARND---RYfWSDDPNMANQEr-- 1238
gi 768922204 1164 IARATTYL-LSQ---MEKLNHPYAVAITVYSLAVClpKET-DHSASWEKLTALAMRGENG---CYlWTTDPSLDNQKA-- 1233
gi 74096023  1171 RVSAMNYL-EQHk-dHATFQRPYPLSLLAYAAALHnpRSQ-LAIEMNARLMAMKQTSGNGa-yVF-WRAKTLAEISGTNA 1245
gi 47209714  1227 MRAAAAYI-SQH---AVGVASVYVRAVATFALTLYdsNSM-AASTLLSSLENLARERGHPaviRY-WQDGERSSEWLKPD 1300
gi 48675959  1168 LTKADTFL-LEN---TRSTRSTFALAIAAYALSLGdkSHP-QFRSIVSALKKEALVKGNPpiyRF-WKDDLQKKDRSVPN 1241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FXG_E        565 T--PAprnps-dpmpqAPALWIETTAYALLHLLLHe-G--------KaEMADQASAWLTRQGSFQGGFRSTQDTVIALDA 632
gi 121995637 1214 RrwWCw----------VWSHDVEITSYALLTLLETeqE--------TpDSVLNTIRWLVAQRNSFGGFASSQDTVVGLQA 1275
gi 74948182  1421 NqkWFslpr---lpyeYDSLNIETTAYALLVYVAR--R--------E-FFVDPIVRWLNSQRLNDGGWASTQDTSAALKA 1486
gi 122067379 1452 NqkYFnlpr---lpykYDSLNIETTAYALLTYVSR--Q--------EtFTVEPIVRWLNSQRLMDGGWASSQDTGIAMKA 1518
gi 341940526 1240 P---TaprsptepvpqAPALWIETTAYALLHLLLRe-G--------KgKMADKAASWLTHQGSFHGAFRSTQDTVVTLDA 1307
gi 157278135 1239 ----------------ADGVTIQTTAYALLTAVQV--K--------NgEWADKIAHWLISQENYNGGFLSTHDTILALEA 1292
gi 768922204 1234 ----------------ATAITVDSTSYALLAAVKL--G--------KiEFSDQIACWLTTQENYLGGFKSSQDTLNALDA 1287
gi 74096023  1246 H--AYwyr------trPLALDIETTSYALLAQVAMs-KakdplvqaDlDLGRKISLWLISQRNSNGGFRSTQDTVIGLQA 1316
gi 47209714  1301 Q---------------SSGVTVETTAYVLLSFLLK--G--------RiHYANPVLTWLTQDHQYGGAFYSGQDTALTLEA 1355
gi 48675959  1242 T---------------GTARMVETTAYALLTSLNL--K--------DmNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEG 1296

                  ....*.
4FXG_E        633 LSAYWI 638
gi 121995637 1276 LIKFAE 1281
gi 74948182  1487 LVEYTV 1492
gi 122067379 1519 LTEYST 1524
gi 341940526 1308 LSAYWI 1313
gi 157278135 1293 LSEYel 1298
gi 768922204 1288 LAEYSl 1293
gi 74096023  1317 LStils 1322
gi 47209714  1356 LTEYSr 1361
gi 48675959  1297 LTEYSl 1302
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