1NIJ


Conserved Protein Domain Family
CobW_C

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pfam07683: CobW_C 
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Cobalamin synthesis protein cobW C-terminal domain
This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.
Statistics
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PSSM-Id: 336765
View PSSM: pfam07683
Aligned: 153 rows
Threshold Bit Score: 35.3085
Threshold Setting Gi: 333016899
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1NIJ_A       224 ISSIVVELDYPVDISEVSRVMENl---lLesA--------DKLLRYKGMLWIDGEPNRLLFQGVQRLYSAD-WDRPW-G- 289
gi 81787203  233 IQAIKLDLEQPVTEKELQRWLID-----Q--G--------DQLIRAKGYVRLQGNDLLVHFQYASKQLSVRk-------s 290
gi 74554798  216 VSSIGLEFTESFKEKDIENIILElk-sgK--Y--------GQIMRGKGFLNIDDK--TMEFNYVGNDCKLEl-------l 275
gi 75542730  255 FESFGIETPKLFPKETLNVILHKlensnY--Y--------GTILRAKGIVQVNEKe-WLQFDYVPEELNIKt-------s 316
gi 74770623    5 ISTVTLEFSHPFNRKLFENAIESil-weR--SvydgsgnlMNLLRLKGFVHFVDDDCTYSLQGLNEIYDISpIPTERsKl 81
gi 75141026  267 ISTLCICEQDPISLSKVESWLEDll-weR--Kl------dMDIYRCKGILHVHNSDQVHTLQAVREVYEVLpAREWSkT- 336
gi 145353273 237 IRTVCIATSGFLDGESFQNWLEDll-weR--Rnae---ggADILRAKGLVYTAGSDKRRVLQAVREVYEITdGPVEEnS- 309
gi 149810000 225 IQPTKIDIPDDVDWATFSIWLSAli-yaR--G--------DDLVRVKGVFDTPAG--PLLLQAVRKSVQPPeFLPAEaA- 290
gi 737422595 218 LGSYVHTFKGPVSQEAFDSFLRE-----L--P--------DSVFRIKGYIKFSAEGYPFLFQFSYGMPLYMk-------e 275
gi 493888674 218 LRAYVHRFTDSISQTDFEEWLRN-----L--P--------DSIYRMKGYIPFSGRRYPFMFQYSYGMPLLLp-------e 275
                         90       100
                 ....*....|....*....|....*...
1NIJ_A       290 DEKPHSTMVFIGIQLPEEEIRAAFAGLR 317
gi 81787203  291 KEEVPPCLILIGVDLNRETLAKSLHTVT 318
gi 74554798  276 NTKKDQKICIIGKNLEKEAVSELFNN-L 302
gi 75542730  317 SPDYTGKICVIGTNLNKLALENLF---L 341
gi 74770623   82 LNLNGTRLILIGHNLCSSILKELLVNCT 109
gi 75141026  337 -ESRTNKIVVIGRNLDINILQDSFSRCK 363
gi 145353273 310 -DEVMNKLVFIGRNLDEDALAVGLKSCV 336
gi 149810000 291 --QRQNQIVFIGRGYKGDDLRRSLDYFT 316
gi 737422595 276 YMNMPLNMVFIGENIDWEQISRKLKDME 303
gi 493888674 276 DMNLPKTLVIIGEDLDENKLKTELQELE 303
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