Conserved Protein Domain Family
MFS_1

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pfam07690: MFS_1 
Major Facilitator Superfamily
Statistics
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PSSM-Id: 311564
View PSSM: pfam07690
Aligned: 192 rows
Threshold Bit Score: 47.0338
Threshold Setting Gi: 134035382
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   86 FFIVIFITAFTAATsNDAGSIQdSL------NEKy----------------------------------------gISYD 119
gi 74639005   42 VSWMTLVVTFSSTC-LLPAAP--EI------ANEf----------------------------------------dMTVE 72
gi 74626738  141 LAYVALCSSFASSV---FAVPAeAI------TTVf----------------------------------------hISLT 171
gi 74638634   48 ISSMTFLNQYGDSV-FAPSIS--NI------AEQf----------------------------------------hASRT 78
gi 74626959   65 ISIGSVCVTCISSS-VALATP--QI------MEHl----------------------------------------dVSHE 95
gi 81626196   19 RFFGELLTSLTGAM-MGPFMVL-YL------HEQl----------------------------------------nGSIM 50
gi 74557105   20 LMFASLAIGYFMWG-VIASI-----------APL------------------------------------------IYPN 45
gi 74868532   61 IFLCKIPAAWFMAC-IIFTGPElYP------GSEftcdtsyltsssnssfsisdnqcyvldestgtsseceqfnyvSSFD 133
gi 74938574   54 LEPAVFLIFFARNL-IGAVYQNqILyqtcitIEKfnatqcepllg---------------------idrgsdadkeVEVI 111
gi 817693574  20 FLIVAFLTGIAGAL-QTPTLSI-FL------TDEv----------------------------------------hARPA 51
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962  120 AMNT----GAGV---LFLGI---GWGTFFL-TPASSL-Y-G--RKI-TYFICIFLGLLG-AVWFA--L---VkstSD--- 174
gi 74639005   73 TINI----SNAG---VLVAM---GYSSLIW-GPMNKL-V-G--RRT-SYNLAISMLCAC-SAGTA------AainEKm-- 127
gi 74626738  172 VSLL----TMTV---FLLGY---CSGPIIW-APLSEL-S-G--RKP-PILIGMLGFGIF-NISVA--V---GkdiQT--- 226
gi 74638634   79 LVTL----GATL---YTLGI---LFGNLIF-APLSEQ-F-G--RRP-IYLIGYSVFALL-QIPIA--L-------SVnl- 131
gi 74626959   96 VAIL----NISF---FILGL---GTGGCFL-SPISEF-H-G--RRI-VYIGGLTTMIAF-EFLTA--F---T---SNig- 149
gi 81626196   51 MPML----IISL---QPFAD---IFLTLAA-GRVTDR-L-G--RRT-AILTALLLQSAAmTGFVF----------AEha- 103
gi 74557105   46 INSV----LFLLtptFAT-----LAGNLAL-SLFSDKkL-G--RKT-TFFITMSLYSVG-TILLV--LasvLagfSTdnl 108
gi 74868532  134 SLIMqfnlVCLRdifVAWTQywhLFGVLVG-GVMGTKmMlGisPRS-TYCVGAVAQILC-GVVTG--Y-------ARdf- 200
gi 74938574  112 VQTYsaniMMTT---SLLESiipAFASLFL-GPWSDK-F-G--RRP-ILLTTFTGYLTGaLILIVitYitrStniSPww- 181
gi 817693574  52 MVGF----FFTG---SAVIG---ILVSQFLaGRSDKR---G--DRKsLIVFCCLLGVLA--CTLFa-W---N---RNyf- 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962  175 -------SIWSQLFVGISEsCAEAQVQLSLSELYFAH------NLGSVL--TSYIVATSVGTYLGPLIAAFIV-QNIG-- 236
gi 74639005  128 -------FIAFRVLSGLTG-TSFMVSGQTVLADIFEPv-----YRGTAV--GFFMAGTLSGPAIA-CVGGVIV-TFTS-- 188
gi 74626738  227 -------IMMCRFFAGFFA-SAPLTVVAAALADMYSNk-----YRGTAI--TLFSAMVFDGPLVSPIVGGFLTkSYLG-- 289
gi 74638634  132 -----amFLVFRFFSGLFG-SVGLSNGSGSLADLFEKk-----DRGKYM--VIYFTVLSIGPGIAPIISGFISqSSIG-- 196
gi 74626959  150 ------aMVFGRFMSGFCG-SSYMSVASGSFADLFKArkkegkDANKEL--SLALILYSVAPFLGPSLGSLISgFINThl 220
gi 81626196  104 -----yvFAILYVMNGIGR-SLYIPASRAQIAESTPEs-----RRSEVF--AVINAIYSTGLTAGPLVGMLLYnHNPV-- 168
gi 74557105  109 akfpsliLIILGIVLGIFGvEGEVPVMLSYTAEMMPLk-----YRDMML--VLAPNFDNIGAMVAALVGYLTYsLSNS-- 179
gi 74868532  201 -----slHCAFRCLSAVCC-AIMFTAGQAIFADITAGm-----HRIGAI--ILYDTFWSIGVILLPGLSSFFN----S-- 261
gi 74938574  182 -----flLSSVPSVVSGGT-CALITGIYCYISDVAKEr-----KKALRM--VLNEASLCAGIMVGNVASGYIY-AATN-- 245
gi 817693574 107 -----vlLFVGVFLSSFG--STANPQMFALAREHADKt-----GREAVMfsSFLRAQVSLAWVIGPPLAYALA-MGFS-- 171
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962  237 -FRWVGWIAAIISGALlfvIVfcLDETYFdrakftkpfitGIAPFDSSYSNGKSDsknsipekqnsvkiesnveskeveq 315
gi 74639005  189 -WRVIFWLQLGMSGLG---LV--LSLLFF-----------PKIEGTSEKVSTAFKpttlvsii----------------- 234
gi 74626738  290 -WRWTEYITSFMGFFA---LI--I--VYL-----------FCDETYSKAIIQGKAkeyraitgnyfvhakse-------- 342
gi 74638634  197 -WQWEFWILLILSGFN---LFwaF--LLL-----------KETYPPVLNRKKFEKygeigenepvalrltg--------- 250
gi 74626959  221 yYRWTFYVFIIWSGVL---LLavV--LFV-----------PETHEPVNLQRKAKRlrkttgdnryyaaadk--------- 275
gi 81626196  169 -WI--FALDAAALFIY---FL--IAALKL-----------PETKPLHPAVTPKMSa------------------------ 205
gi 74557105  180 -FIIELLALTVVAILGivtAV--IIRLLL-----------PESVRWLATKGDINKakieaskv----------------- 228
gi 74868532  262 -WSLIYVGITFPTIML---IL-----LLY-----------WTPDSPRWLLRHAADrfsidnveqilregaaindrsfkip 321
gi 74938574  246 -ALVLFSIAGSLMMFA-------LMYVLL-----------FVPESLNPGDIHTGSrvreffrf----------------- 289
gi 817693574 172 -FTVMYLSAAVAFIVC---GV--M--VWL-----------FLPSMQKELPLATGTveap--------------------- 211
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962  316 sdddianegendppisywkrtamitpatnlkgtgFKQYINQLk-------------lLLKVFLYPpviysGFCWGIqnal 382
gi 74639005  235 --------------------------skfsptdvLKQWVYPNvflavsaweicplhlLETKCSCRkqkdlCCGLLA---- 284
gi 74626738  343 -----------------eevltlsdiaknyllvpMKLLFTEPi--------------CFLITLYS-----SFVYAI---- 382
gi 74638634  251 ------------------kqllikllillsmkkpISILLSQPi--------------LICVACTI-----GSIYGMinlv 293
gi 74626959  276 ------------------qttslyesvltsskrpILLLLKDNmtalln----lytgfTLAVVYLF-----FVAFPY---- 324
gi 81626196  206 ----------------------------------SFTIYRPV---------------LLLLLLSL-----PISMLYaqte 231
gi 74557105  229 --------------------------vkdgtteaKEVNVNKK---------------LSLGSRYA-----FLAIIGlsqy 262
gi 74868532  322 p--------dfrqqleqlserlkaqpppapwtelWKGKRAKTh-------------mVAAHLALA-----FFVINF---- 371
gi 74938574  290 ---------------------------dlvtdliRTCFKRRPnfdr-------tiiwLTMIALTI------AIFDMeges 329
gi 817693574 212 -----------------------------------rrnRRDTl-------------lLFVICTLM-----WGSNSL---- 234
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962  383 LTFYLTVedd-qyyDPPYSYG-------NIAVGLMNIPCLIGAIIg--CFFAGTLS-DYftiylakRNKgiqeaEYRLWF 451
gi 74639005  285 ITQYSILtsaraifNSRFHLTtalvsglFYLA--PGAGFLIG------SLVGGKLSdRTvrr--yiVKR-----GFRLPQ 349
gi 74626738  383 LYLLLEAy------PIIFGEKrhf-smgVAELPYIGLLVGVFIGSginIAFEPWYY-RKclaqggkPDP-----EARLPP 449
gi 74638634  294 LIAFSEVw------KSSYDFSpgi-sglMYISITLGLFSAVFIAMpinQKFYSYLV-KRng---geGEP-----EFRLPM 357
gi 74626959  325 IFSTVYHf-----tISEQGMS-------FLGLVVGMVSTCLISPY---FIDKGYVAlLRknn--gvAKP-----EFRFIP 382
gi 81626196  232 TTYRLFS-------KNMFSDY-------LSMLTIYSAAKALFSCVlqvPLVKGT---EK-------LSM-----KTILFI 282
gi 74557105  263 LTYGLMAf-----vVADYYFSs------SQTPFIIFIANLGASIS---GFIAAYIA-NK-------IRT-----RIFALI 315
gi 74868532  372 MGMLLNIr------SFGRDYL-------VPNTIAMGFSEIIGCFL---ALHFTLKH-NK-------WKW-----QCAGVF 422
gi 74938574  330 TVNYMFV-------QDKFNWT-------IKDFSLFNASRIVIQIV---GSIVGMLVlRR-----------------VLKM 375
gi 817693574 235 YIINMPLf-----iINELHLPe------KLAGVMMGTAAGLEIPT---MLIAGYFA-KR-------LGK-----RFLMRV 287
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962  452 LLPPAIIAPVGLILFAVG----TDQVWSWV----PTYIglgfIGF-GYGCA----GDVSMSYLMDSYPNAVIETMTVVAV 518
gi 74639005  350 DRLHSGLITLFAVLPAGT----LIYGWTLQedkgGMVVpiiaAFFaGWGLMgs-fNCLNTYVAVEALPRNRSAVIAGKYM 424
gi 74626738  450 MMIGCFMFPAGIFWLSWSgh-ySYVNWVVP----ALSG----LAT-GCGILli-fLQCINYLIDAYL--FRAASAIAANT 516
gi 74638634  358 GFIGITLFEIGILLFGWT----ARYKIFWF----VPTIgsaiMGG-GYIMT----SNPLNMYVVDSY--GIYSASASAGV 422
gi 74626959  383 LMVGAFVVPIGLFIIAWT----SYSHIHWI----APIIgsavYGS-GTILV----FNSIFAYTVEAY--RLYAASAMATN 447
gi 81626196  283 TYICYSLAAAGFACSTSL----------------TMLLvtaaVMTvGESIG----LTHIQTFISKLAPPHLLGRFYAVYG 342
gi 74557105  316 SYVGGSLSMIPILYLTTN----FNFGMFY-----SLLI----VNMlFSEFS----WAIRTIYEPVLMPKKLRAFMIGLIR 378
gi 74868532  423 NILAGILGCMGWIFTNADsmdaDLKVSLWM----IIAT----IPKaAVSCA----QSMILACMNELM--PANKKQLFVFS 488
gi 74938574  376 SIVTMAMLSLACCVLEST----VRATAVYW----QELY----LGM-TLGMMrgvmGPMCRAILSHVAPATEVGKIFALTT 442
gi 817693574 288 AAVGGVCFYAGMLMAHSP----------------VILLglqlLNAiFIGIL----GGIGMLYFQDLMP-GQAGSATTLYT 346
                        570
                 ....*....|..
gi 74626962  519 -INNCIGCVFTF 529
gi 74639005  425 -IQYSFSAGSSA 435
gi 74626738  517 -IMRSAMAAGFP 527
gi 74638634  423 kIFQLLLGAIFP 434
gi 74626959  448 sLTRSVLSCIFP 459
gi 81626196  343 -LHWDISRSIGP 353
gi 74557105  379 -----LVPITAY 385
gi 74868532  489 vVTWARVWLLSA 500
gi 74938574  443 -SMESVSPLGAA 453
gi 817693574 347 -NTSRVGWIIAG 357
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