Conserved Protein Domain Family
MFS_1

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pfam07690: MFS_1 
Major Facilitator Superfamily
Statistics
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PSSM-Id: 336768
View PSSM: pfam07690
Aligned: 192 rows
Threshold Bit Score: 47.0316
Threshold Setting Gi: 134035382
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962    86 FFIVIFITAFTAATsNDAGSIQdSL------NEKy-------------------------------gISYDA-----MNT 123
gi 74639005    42 VSWMTLVVTFSSTC-LLPAAP--EI------ANEf-------------------------------dMTVET-----INI 76
gi 74626751    89 LFVATVYTFLEVYV-IWSSTACiNF------FDIy-----------------------------------------qTNW 120
gi 74638837   123 ISFLTTSVYMGSAV-YTPGIE--EL------MHDf-------------------------------gIGRVV-----ATL 157
gi 74626738   141 LAYVALCSSFASSV---FAVPAeAI------TTVf-------------------------------hISLTV-----SLL 175
gi 1064244096  48 ISSMTFLNQYGDSV-FAPSIS--NI------AEQf-------------------------------hASRTL-----VTL 82
gi 74626959    65 ISIGSVCVTCISSS-VALATP--QI------MEHl-------------------------------dVSHEV-----AIL 99
gi 74938574    54 LEPAVFLIFFARNL-IGAVYQNqILyqtcitIEKfnatqcepllg------------idrgsdadkeVEVIV-----QTY 115
gi 74871610    66 VANNVTVEPILAAY-IMPSVLSnLA------TQNlnlekacrvnmaygdevcdaltrrqtanytleeETVQQmvarmAAW 138
gi 817693574   20 FLIVAFLTGIAGAL-QTPTLSI-FL------TDEv-------------------------------hARPAM-----VGF 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   124 ----GAGV---LFL--GI---GWGTFFL-TPA--SSLYGRKI-TYFICIFLGLLG-AVWFA-----L---VkstSD---- 174
gi 74639005    77 ----SNAG---VLV--AM---GYSSLIW-GPM--NKLVGRRT-SYNLAISMLCAC-SAGTA---------AainEKm--- 127
gi 74626751   121 ----HCSIqvsYLVqsLFivgNAFGPMLlGPM--SDIFGRKW-VYVGSLILYIIF--QIPQa----L---A---YNlp-m 180
gi 74638837   158 ----PLTL---FVI--GY---GVGPLVF-SPMseNAIFGRTS-IYIITLFLFVIL---QIPt---aL---V---NNia-g 210
gi 74626738   176 ----TMTV---FLL--GY---CSGPIIW-APL--SELSGRKP-PILIGMLGFGIF-NISVA-----V---GkdiQT---- 226
gi 1064244096  83 ----GATL---YTL--GI---LFGNLIF-APL--SEQFGRRP-IYLIGYSVFALL-QIPIA-----L-------SVnlam 133
gi 74626959   100 ----NISF---FIL--GL---GTGGCFL-SPI--SEFHGRRI-VYIGGLTTMIAF-EFLTA-----F---T---SNig-a 150
gi 74938574   116 saniMMTT---SLL--ESiipAFASLFL-GPW--SDKFGRRP-ILLTTFTGYLTGaLILIVi---tYitrStniSPwwfl 183
gi 74871610   139 ----KTVI---QSL--FP---CLLILFW-GSW--SDRHRRRKpCILIPVVGEFLG--VVGLmlcvyFeqaPmeaAAlt-e 200
gi 817693574   56 ----FFTG---SAV--IG---ILVSQFLaGRS--DKR-GDRKsLIVFCCLLGVLA--CTLFa----W---N---RNyfvl 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   175 SIWSQLFVGISEsCAEAQVQLSLSELYFAH------NLGSVL--TSYIVATSVGTYLGPLIAAFIV-QNIG---FRWVGW 242
gi 74639005   128 FIAFRVLSGLTG-TSFMVSGQTVLADIFEPv-----YRGTAV--GFFMAGTLSGPAIA-CVGGVIV-TFTS---WRVIFW 194
gi 74626751   181 MAINSAIAGAFG-SSALANVASSMCDIFTPe-----TVGFGI--SLFVWGANAGASIGSPIGEALY-DH-----WRWFYW 246
gi 74638837   211 LCILRFLGGFFA-SPCLATGGASVADVVKFw-----NLPVGL--AAWSLGAVCGPSFGPFFGSILT-VKAS---WRWTFW 278
gi 74626738   227 IMMCRFFAGFFA-SAPLTVVAAALADMYSNk-----YRGTAI--TLFSAMVFDGPLVSPIVGGFLTkSYLG---WRWTEY 295
gi 1064244096 134 FLVFRFFSGLFG-SVGLSNGSGSLADLFEKk-----DRGKYM--VIYFTVLSIGPGIAPIISGFISqSSIG---WQWEFW 202
gi 74626959   151 MVFGRFMSGFCG-SSYMSVASGSFADLFKArkkegkDANKEL--SLALILYSVAPFLGPSLGSLISgFINThlyYRWTFY 227
gi 74938574   184 LSSVPSVVSGGT-CALITGIYCYISDVAKEr-----KKALRM--VLNEASLCAGIMVGNVASGYIY-AATN---ALVLFS 251
gi 74871610   201 AIFPSLSGGWFT---MLMGVFSYIADITTEe-----DRTLRI--GILNVCFSVGVPIGMAFSGVLL-KQIG---FYGVFS 266
gi 817693574  109 LFVGVFLSSFG--STANPQMFALAREHADKt-----GREAVMfsSFLRAQVSLAWVIGPPLAYALA-MGFS---FTVMYL 177
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   243 IAAIISGALlfvIVfcLDETYFdrakftkpfitGIAPFDSSYSNGKSDsknsipekqnsvkiesnveskeveqsdddian 322
gi 74639005   195 LQLGMSGLG---LV--LSLLFF-----------PKIEGTSEKVSTAFKpttlvsii------------------------ 234
gi 74626751   247 MNMIVGGFF---VI--L--CVLcp--------eTLPVINIMNYSSTTGektvqvstlakak------------------- 292
gi 74638837   279 FMCIISGFS---FV--M--LCF-----------TLPETFGKTLLYRKAkrlraitgndritsegei-------------- 326
gi 74626738   296 ITSFMGFFA---LI--I--VYL-----------FCDETYSKAIIQGKAkeyraitgnyfvhakse--------------- 342
gi 1064244096 203 ILLILSGFN---LFwaF--LLL-----------KETYPPVLNRKKFEKygeigenepvalrltg---------------- 250
gi 74626959   228 VFIIWSGVL---LLavV--LFV-----------PETHEPVNLQRKAKRlrkttgdnryyaaadk---------------- 275
gi 74938574   252 IAGSLMMFA-------LMYVLL-----------FVPESLNPGDIHTGSrvreffrf------------------------ 289
gi 74871610   267 ISAAFYVIA---FV--Y--GFF-----------FLEEPQSRPEKSAEQkslladffdkeh-------------------- 308
gi 817693574  178 SAAVAFIVC---GV--M--VWL-----------FLPSMQKELPLATGTveap---------------------------- 211
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   323 egendppisywkrtamitpatnlkgtgFKQYINQLk-------------lLLKVFLYPpviysGFCWGIqnalLTFYLTV 389
gi 74639005   235 -------------------skfsptdvLKQWVYPNvflavsaweicplhlLETKCSCRkqkdlCCGLLA----ITQYSIL 291
gi 74626751   293 --------------savvrtkfvlstaFKLLCTEPiim----------alGLYNGFAY-----GLIFLY----LDGLFPV 339
gi 74638837   327 ---------enskmtsheliidtlwrpLEITVMEPvvl----------liNIYIAMVY-----S-ILYL----FFEVFPI 377
gi 74626738   343 ----------eevltlsdiaknyllvpMKLLFTEPi--------------CFLITLYS-----SFVYAI----LYLLLEA 389
gi 1064244096 251 -----------kqllikllillsmkkpISILLSQPi--------------LICVACTI-----GSIYGMinlvLIAFSEV 300
gi 74626959   276 -----------qttslyesvltsskrpILLLLKDNmtalln----lytgfTLAVVYLF-----FVAFPY----IFSTVYH 331
gi 74938574   290 --------------------dlvtdliRTCFKRRPnfdr-------tiiwLTMIALTI------AIFDMegesTVNYMFV 336
gi 74871610   309 ----------------vvqtfrvafkkGENQRRKRvil----------lmIVVMVIIG-----PLHGEM----AVTYLFT 353
gi 817693574  212 ----------------------------rrnRRDTl-------------lLFVICTLM-----WGSNSL----YIINMPL 241
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   390 edd-qyyDPPYSYG--------NIAVGLMNIPCLIGAIIg--CFFAGTLS-DYftiylakRNKgiqeaEYRLWFLLPPAI 457
gi 74639005   292 tsaraifNSRFHLTtalv-sglFYLA--PGAGFLIG------SLVGGKLSdRTvrr--yiVKR-----GFRLPQDRLHSG 355
gi 74626751   340 f------VDNYKMGymg--anlTYLN--FLVGVTIVVMLqpiQNWLYRWD-KRrhg--gvARP-----EARFLISLLTVW 401
gi 74638837   378 y-----fVGVKHFTlvelgttyMSIV--IGIVIAAFIYI---PVIRQKFT-KP-------ILR-----QEQVFPEVFIPI 434
gi 74626738   390 y------PIIFGEKrhf--smgVAELPYIGLLVGVFIGSginIAFEPWYY-RKclaqggkPDP-----EARLPPMMIGCF 455
gi 1064244096 301 w------KSSYDFSpgi--sglMYISITLGLFSAVFIAMpinQKFYSYLV-KRng---geGEP-----EFRLPMGFIGIT 363
gi 74626959   332 f-----tISEQGMS--------FLGLVVGMVSTCLISPY---FIDKGYVAlLRknn--gvAKP-----EFRFIPLMVGAF 388
gi 74938574   337 -------QDKFNWT--------IKDFSLFNASRIVIQIV---GSIVGMLVlRR-----------------VLKMSIVTMA 381
gi 74871610   354 -------RFRFNWSeve--fsfFSTY--AMFTGLIGVIF-----CVGILS-HK-------LNI-----DDALVGVLSSTS 404
gi 817693574  242 f-----iINELHLPe-------KLAGVMMGTAAGLEIPT---MLIAGYFA-KR-------LGK-----RFLMRVAAVGGV 293
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74626962   458 IAPVGLILFAVG---TDQVWSWV------PTYIglgfIGF-GYGCA----GDVSMSYLMDSYPNAVIETMTVVAV-INNC 522
gi 74639005   356 LITLFAVLPAGT---LIYGWTLQed--kgGMVVpiiaAFFaGWGLMgs-fNCLNTYVAVEALPRNRSAVIAGKYM-IQYS 428
gi 74626751   402 FFPAGLFWFAFT---SDGRISWV------SPLIaggvLGV-GDPQL----WLAMINYITDSYP-SVAGSAIAAFTlPSFA 466
gi 74638837   435 AIVGGILLTSGL---FIFGWSANrtthwvGPLFgaatTAS-GAFLI----FQTLFNFMGASFKPHYIASVFASND-LFRS 505
gi 74626738   456 MFPAGIFWLSWSghySYVNWVVP------ALSG----LAT-GCGILli-fLQCINYLIDAYL--FRAASAIAANT-IMRS 520
gi 1064244096 364 LFEIGILLFGWT---ARYKIFWF------VPTIgsaiMGG-GYIMT----SNPLNMYVVDSY--GIYSASASAGVkIFQL 427
gi 74626959   389 VVPIGLFIIAWT---SYSHIHWI------APIIgsavYGS-GTILV----FNSIFAYTVEAY--RLYAASAMATNsLTRS 452
gi 74938574   382 MLSLACCVLEST---VRATAVYW------QELY----LGM-TLGMMrgvmGPMCRAILSHVAPATEVGKIFALTT-SMES 446
gi 74871610   405 KILSSFVYAFAT-----LPWHMY------LGGL----VEI-FNGTA----FIAMRSIATKLVSKDELGKVNSLFG-VAEA 463
gi 817693574  294 CFYAGMLMAHSP-----------------VILLglqlLNAiFIGIL----GGIGMLYFQDLMP-GQAGSATTLYT-NTSR 350

                  ....*..
gi 74626962   523 IGCVFTF 529
gi 74639005   429 FSAGSSA 435
gi 74626751   467 IAAVLVH 473
gi 74638837   506 VIASVFP 512
gi 74626738   521 AMAAGFP 527
gi 1064244096 428 LLGAIFP 434
gi 74626959   453 VLSCIFP 459
gi 74938574   447 VSPLGAA 453
gi 74871610   464 LMPMVFA 470
gi 817693574  351 VGWIIAG 357
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